The UCLA-DOE Gene to Structure Partnership enables researchers to begin with a protein sequence and obtain a macromolecular structure using a synergistic approach. UCLA-DOE Cores collaborate with users to provide consultation and access to high-throughput, cutting edge technologies, while users provide direction and are involved in the process.
Crystals of the sample are screened at the X-ray Core. Users are trained to harvest crystals, screen crystals and collect data. Data is collected and structures may be solved in-house. Additionally, crystals which diffract best are selected and sent for data collection at high-powered sources.
The UCLA-DOE staff maintains heavy engagement with users throughout the process.