Todd O. Yeates, Professor
UCLA-DOE Institute Director
Structural, computational, and synthetic biology. Current focus is on large protein assemblies, including natural structures such as the carboxysome and other bacterial microcompartments, and designed structures built from novel self-assembling protein molecules.
Office: (310) 206-4866
Lab: (310) 205-8901
255 Boyer Hall
yeates@mbi.ucla.edu
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Keriann Backus, Assistant Professor
ALGAL FUNCTIONAL GENOMICS
We investigate how protein function and cellular fate can be studied and manipulated by chemical probes. By developing new methods that combine chemical biology, genomics, and proteomics, we aim to identify functional, disease-linked, and probe-accessible pockets in human proteins. Current applications of our methods include: (i) the production of probes to alter protein interactions, (ii) precision anti-cancer probes, and (iii) probes that enhance T cell proliferation.
Departments of Biological Chemistry and Chemistry and Biochemistry
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James Bowie, Professor
SYNTHETIC BIOCHEMISTRY: ENZYME AND PATHWAY DESIGN
Membrane protein structure, SAM Domains: A Biological Polymer, Synthetic Biochemistry for Green Production of Chemicals and Biofuels.
Office: (310) 206-4747
Lab: (310) 206-4748
Fax: (310) 206-4749
655 Boyer Hall
bowie@mbi.ucla.edu
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Siobhan Braybrook, Assistant Professor
Our research is aimed at understanding how shapes are physically established and grown in walled organisms.
siobhanb (at) ucla.edu
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Robert T. Clubb, Professor
MICROBIAL METABOLISM CHEMISTRY AND COMMUNITIES
SYNTHETIC BIOCHEMISTRY: ENZYME AND PATHWAY DESIGN
Engineering microbial surfaces; Mechanisms of bacterial pathogenesis; Function of cell surface virulence factors in Staphylococcus aureus and Bacillus anthracis; Heteronuclear multidimensional NMR spectroscopy.
Office: (310) 206-2334
Lab: (310) 226-3044
602 Boyer Hall
rclubb@mbi.ucla.edu
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David S. Eisenberg, Professor
ATOMIC IMAGING TECHNOLOGIES AND NOVEL STATES OF MATTER FOR PROTEINS
Center For Global Mentoring
Study of biochemical macromolecules by X-ray diffraction and computational methods; structure and action of enzymes and of membrane-related proteins; protein folding and the atomic basis of biological recognition.
National Academy of Sciences Member
Office: (310) 825-3754
Lab: (310) 825-8901
Fax: (310) 206-3914
201 Boyer Hall
david@mbi.ucla.edu
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Robert P. Gunsalus, Professor
MICROBIAL METABOLISM CHEMISTRY AND COMMUNITIES
Office: (310) 206-8201
Fax: (310) 206-5231
609 Charles E Young Dr
robg@microbio.ucla.edu
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Joseph A. Loo, Professor
Development of novel bioanalytical and proteomics methods for the characterization of proteins and their post-translational modifications. Proteomics of cell surfaces. Development of mass spectrometry for the study of macromolecular complexes, protein-ligand interactions, and their application to structural biology.
Office: (310) 794-7023
402 Boyer Hall
jloo@chem.ucla.edu
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Sabeeha Merchant, Professor
ALGAL FUNCTIONAL GENOMICS
Algal genomics, RNA-seq, photosynthesis, trace micronutrient homeostasis, membrane assembly, chloroplast metabolism.
National Academy of Sciences Member
Office: (310) 825-8300
Lab: (310) 825-3661
Fax: (310) 206 -5213
5070A Young Hall
sabeeha@chem.ucla.edu
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Matteo Pellegrini, Professor
ALGAL FUNCTIONAL GENOMICS
MICROBIAL METABOLISM CHEMISTRY AND COMMUNITIES
Our lab is interested in the development of computational approaches to interpret genomic data. These methodologies allow us to develop annotated genomes, epigenomes and transcriptomes. Our approach is to integrate these data layers that are produced using the latest generation of high throughput sequencers. For instance we are developing suites of tools for the analysis of DNA methylation data, as well as tools to annotate genomes using RNA sequences.
Office: (310) 825-0012
Lab: (310) 825-0274
Fax: (310) 206-3987
3000C Terasaki Life Sciences Building
matteop@mcdb.ucla.edu
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Shimon Weiss, Professor
MICROBIAL METABOLISM CHEMISTRY AND COMMUNITIES
Single molecule biophysics, single molecule spectroscopy, superresolution imaging
Office: (310) 794-0093
Fax: (310) 267-4672
2037A Young Hall
sweiss@chem.ucla.edu
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