Methanospirillum
hungatei cells and
flagella structure
(Gunsalus Lab)

Development of a new enzyme

reagent that labels proteins with

peptides via a specific lysine-isopeptide

bond at high yield (Clubb lab)

Heatmap representing gene expression for 11,306 differentially expressed genes over the diurnal cycle.

Genome-wide transcriptomics in Chlamydomonas reinhardtii

during day-night cycles reveals new metabolic patterns in

light and stress response (Merchant lab)

Near-atomic cryo-EM imaging
of a small protein displayed on
a designed scaffolding system
(Yeates Lab)

Understanding Tau’s Role in Origin and Spread of Alzheimer’s Disease (Eisenberg Lab)

Atomic structures
of low-complexity
protein segments
reveal kinked β sheets
that assemble networks
(Eisenberg Lab)

Welcome

The UCLA-DOE Institute is a team of research laboratories working on fundamental research and technology developments in broad DOE mission areas ranging from microbes, to biofuels and green chemistry, to the design of new biomaterials.

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ALGAL FUNCTIONAL GENOMICS

Sabeeha Merchant, Siobhan Braybrook, Matteo Pellegrini, Keriann Backus

Using state of the art methodologies for genome-wide approaches to probe the enzymology, cell biology and metabolism of organisms that contribute to carbon capture and primary productivity

MICROBIAL METABOLISM, CHEMISTRY AND COMMUNITIES

Robert Gunsalus, Robert Clubb, Joseph Loo, Matteo Pellegrini

Deciphering the metabolism of syntrophic microbial communities and the biogenesis of the cellulosome appendage of the model cellulose degrading microbe, Clostridium thermocellum

SYNTHETIC BIOCHEMISTRY: ENZYME AND PATHWAY DESIGN

James Bowie, Robert Clubb, Todd Yeates

Developing new technologies to carry out important biosynthetic and biodegradation reaction schemes in vitro through the design of novel pathways and enzyme systems

ATOMIC IMAGING TECHNOLOGIES AND NOVEL STATES OF MATTER FOR PROTEINS

Jose Rodriguez, David Eisenberg, Todd Yeates

Pioneering the new method of micro-electron diffraction (microED); revealing microscale substructure within protein crystals at unprecedented levels of detail