The UCLA-DOE IGP brings together research on important bioenergy subjects as one integrated unit. Central questions concern the way microbes use energy to degrade plant feedstocks, and how plant cell growth and function connects to genomic information. The IGP approaches these questions through an atomic level understanding of components and their interactions. Novel enabling capabilities are being developed to advance our understanding of microbial and plant systems. Systems under study by the Microbe and Plant teams serve as testbeds for new capabilities, with new methods propagating to the broader DOE research communities.