Professor David S. Eisenberg
Post Doctoral Fellows
I am a postdoc in Eisenberg’s lab and my research here mostly focuses on the interaction between Amyloid beta (Aβ) and its binders (binding proteins/small molecules). My goal is to solve the crystal structure of binder stabilized Aβ (or Aβ derived peptides), or developing Aβ inhibitors from these binding protein/small molecules.
My research focuses on determining the molecular structures of Amyloid Beta (Aβ), the protein responsible for Alzheimer’s Disease. Aβ is observed as multiple aggregated structures including amyloid fibrils, smaller protofibrils, as well as oligomeric species which are associated with higher toxicities. By determining the structures of the distinct species, I hope to identify what features are responsible for Aβ toxicity. To this end, I have focused on familial mutations in Aβ which alter the structure and contribute to heightened toxicity and early onset of the disease.
I help people to determine and analyze interesting macromolecular structures by crystallography. I assist with data collection, data processing, phasing, model building and structure interpretation, and teach others about these techniques.
Boston University Class of 2014, BA in Chemistry, minor in Mathematics