Understanding Tau’s Role in Origin and Spread of Alzheimer’s Disease (Eisenberg Lab)

Atomic structures
of low-complexity
protein segments
reveal kinked β sheets
that assemble networks
(Eisenberg Lab)

Finer Structure of α-Synuclein,
Aβ Fibrils determined (Eisenberg Lab)

Diffusion accessibility as a method for visualizing
macromolecular surface geometry (Yeates Lab)

Conserved SMP domains of the ERMES complex bind
phospholipids + mediate tether assembly (Egea Lab)

Welcome

The UCLA-DOE Institute is a team of research laboratories working on fundamental research and technology developments in broad DOE mission areas ranging from microbes, to biofuels and green chemistry, to the design of new biomaterials.

We are funded by the Biological and Environmental Research (BER), the Biological Systems Science Division (BSSD).  STRATEGIC PLAN October 2015

Division of Microbial Genomics and Proteomics

Unicellular organisms account for a substantial fraction of global primary productivity. They represent the most evolutionarily and metabolically diverse organisms, with capacity to thrive in highly specialized environmental niches. In this Division, we apply emerging technologies to define and probe the genomes, proteomes and metabolism of prokaryotic and eukaryotic microbes. Our research efforts emphasize genome-level interpretations, especially in the context of the environment and in relation to other species, and offer a substantial component of discovery in uncharted metabolic pathways.

Division of Systems Biology and Design

Biological systems are distinguished by their high level of organization. Their composition from multiple interacting components allows them to exhibit many kinds of complex behaviors, enabling chemical transformations and synthetic processes that are often tightly regulated and/or spatially controlled for optimal performance. In this Division, we apply emerging technologies to dissect and re-engineer complex biochemical processes and structures. Our efforts aim to create advanced chemicals and novel biologically-based materials in support of DOE interests in energy, green chemistry, and bioprocessing.

Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system

Significance New electron microscopy (EM) methods are making…

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

Interactions of LARKS protein domains More than 1500 human proteins…

Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets

Control of metabolism by compartmentation is a widespread feature…

Structure-based inhibitors of tau aggregation

Published in Nature Chemistry Aggregated tau protein is associated…

Protocols for some Crystallization Stock Solutions

Dan Anderson We have our own water machine to make HPLC…

How to Prepare Heavy Atom Derivatives with Dimethyl Mercury and Tetraethyl Lead

How to Prepare Heavy Atom Derivatives with Dimethyl Mercury and…