De novo phasing
with X-ray laser
reveals mosquito
larvicide BinAB

sawaya_science_pnas_1xSlide thumbnail

Eisenberg lab
produces first
Ab Initio protein
structure from prion
nanocrystals at
atomic resolution

UCLA-DOE PI’s visit the Pacific Northwest National Laboratory

to team up on new research projects involving state-of-the-art scientific instrumentation.

Accurate design
of megadalton-scale
icosahedral protein
complexes. (Yeates Lab)
Science, 2016 Jul. 22


Finer Structure of α-Synuclein, Aβ Fibrils determined (Eisenberg Lab)


Diffusion accessibility as a method for visualizing macromolecular surface geometry (Yeates Lab)


The UCLA-DOE Institute is a team of research laboratories working on fundamental research and technology developments in broad DOE mission areas ranging from microbes, to biofuels and green chemistry, to the design of new biomaterials.

We are funded by the Biological and Environmental Research (BER), the Biological Systems Science Division (BSSD).  STRATEGIC PLAN October 2015

Division of Microbial Genomics and Proteomics

Unicellular organisms account for a substantial fraction of global primary productivity. They represent the most evolutionarily and metabolically diverse organisms, with capacity to thrive in highly specialized environmental niches. In this Division, we apply emerging technologies to define and probe the genomes, proteomes and metabolism of prokaryotic and eukaryotic microbes. Our research efforts emphasize genome-level interpretations, especially in the context of the environment and in relation to other species, and offer a substantial component of discovery in uncharted metabolic pathways.

Division of Systems Biology and Design

Biological systems are distinguished by their high level of organization. Their composition from multiple interacting components allows them to exhibit many kinds of complex behaviors, enabling chemical transformations and synthetic processes that are often tightly regulated and/or spatially controlled for optimal performance. In this Division, we apply emerging technologies to dissect and re-engineer complex biochemical processes and structures. Our efforts aim to create advanced chemicals and novel biologically-based materials in support of DOE interests in energy, green chemistry, and bioprocessing.

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