Finer Structure of α-Synuclein, Aβ Fibrils determined (Eisenberg's Lab)


Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly

Division of Microbial Genomics and Proteomics

Unicellular organisms account for a substantial fraction of global primary productivity. They represent the most evolutionarily and metabolically diverse organisms, with capacity to thrive in highly specialized environmental niches. In this Division, we apply emerging technologies to define and probe the genomes, proteomes and metabolism of prokaryotic and eukaryotic microbes. Our research efforts emphasize genome-level interpretations, especially in the context of the environment and in relation to other species, and offer a substantial component of discovery in uncharted metabolic pathways.

Division of Systems Biology and Design

Biological systems are distinguished by their high level of organization. Their composition from multiple interacting components allows them to exhibit many kinds of complex behaviors, enabling chemical transformations and synthetic processes that are often tightly regulated and/or spatially controlled for optimal performance. In this Division, we apply emerging technologies to dissect and re-engineer complex biochemical processes and structures. Our efforts aim to create advanced chemicals and novel biologically-based materials in support of DOE interests in energy, green chemistry, and bioprocessing.

Latest News

Diffusion accessibility as a method for visualizing macromolecular surface geometry.

Published in Protein Science, Oct 2015. Important three-dimensional spatial features such as depth and surface concavity can be difficult to convey clearly in the context of two-dimensional images. In the area of macromolecular visualization, the computer graphics technique of ray-tracing can be helpful, but further techniques for emphasizing surface concavity can give clearer perceptions of […]


Electron Microscope Yields Finer Structure of α-Synuclein, Aβ Fibrils

  Via ALZFORUM on 17 Sep 2015: “Protein aggregates associated with neurodegenerative disease have stubbornly resisted researchers’ efforts to get a good look at them. They refuse to crystallize well or yield to standard spectroscopic techniques. Now, advances in electron microscopy methods are forcing these molecules to give up their secrets. In the September 9 Nature, […]


Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly

In a new PNAS article, members of the UCLA-DOE Institute, Andrew AhYoung, Pascal Egea, and Joseph Loo, together with Jiansen Jiang, Jiang Zhang, and Hong Zhou,  have offered further elucidation on the structure and function of the conserved SMP domains in the ERMES complex. The new article asserts the roles played by conserved SMP domains of ERMES in […]

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