Research Faculty, UCLA Technology Center, Eisenberg, Yeates, Dickerson, Bowie Labs
My research involves X-ray crystallographic studies of macromolecular assemblies and enzymes involved in DNA metabolism, such as helicase/primase, dihydrofolate reductase (DHFR) and DNA polymerase beta (polB). Past projects include construction of a crystallographic movie of DHFR, depicting loop and subdomain conformational movements during one turnover of substrate. I have also written a web server for treating anisotropy in X-ray crystallographic data sets. I work at the UCLA-DOE Molecular Biology Institute.