I am performing a new alternative splicing calculation for mouse, using the latest mRNA/EST data and mouse genome sequence. I am expecting it to finish sometime next month. Once it's done, the data will be released through our online database ASAP (Alternative Splicing Annotation Project).
Recently, there have been several studies to look into the Ka/Ks of alternatively spliced genes. These studies have advanced our knowledge about the selective force on alternatively spliced genes during evolution. Studies on the Ks of alternatively spliced exons also reveal widespread "RNA-level" selection pressure in the mammalian genomes that are not associated with functional constraints on proteins. Synonymous mutations in alternatively spliced exons are NOT selectively neutral, but are under strong functional constraints for proper regulation of alternative splicing.
I'll write about these studies in detail next week.
Integration of Structural and Functional Genomics
Sept 22-25, Iowa State University
S*STAR.ORG. Click here to download lectures.
Alan Fersht's editorial on how to publish in PNAS.
I am reading Hunter Fraser's work. Very interesting and impressive.
Tapestry of Life: Lateral Transfers of Heritable Elements
Organizers: Siv Andersson, Jonathan Eisen, Claire Fraser, and Jeffrey Gordon
Co-Chairs: Claire Fraser and Jeffrey Gordon
Beckman Center, Irvine, California
December 12-13, 2005
My advisor, Chris Lee, has a software demo in ISMB about his recent work on PyGr. Take a look here.