February 28, 2005

Alternative splicing of membrane proteins

I am going to give a 15-min talk at the EB2005 meeting in San Diego. Something I worked on two years ago, about the impact of alternative splicing on transmembrane proteins. Click to get the paper

Hopefully this topic can connect well with the general audience of EB2005. Any suggestion is welcomed.

Abstract Title:
Alternative splicing frequently produces soluble isoforms of membrane proteins

Society:
Biochemistry/Molecular Biology (ASBMB)

Topic:
2026-ASBMB Deciphering Genomes and Proteomes (Genomes and Proteomes Topic)

Posted by yxing at 02:45 AM | Comments (0)

February 12, 2005

Predicting Alternatively Spliced Exons

In recent months, several groups published papers about predictive identification of alternative exons from genomic sequences. These papers come from Rotem Sorek, Brenton Graveley and Chris Burge lab.

These work utiltize features that are characteristic of functional alternative exons. For example, alternatively spliced exons are in general shorter. They have slightly weaker splice sites, and are more likely to be in frame. The most important discriminative features probably come from comparative genomics. For example, functional alternative exons are usually spanned by highly conserved intronic sequences.

Posted by yxing at 01:12 PM | Comments (1)

February 08, 2005

Alternative Splicing SIG meeting at ISMB 2005

There will be an Alternative Splicing Special Interest Group (SIG) meeting at ISMB 2005 this coming June. Please click the link to see the details.

Posted by yxing at 03:03 AM | Comments (1)