Amyloid Fibril Models
coordinates
and interactive illustrations with Chime
Shilpa Sambahivan,
Rebecca Nelson, Magdalena Ivanova, Michael R. Sawaya, Stuart Sievers,
Michael J. Thompson, Melinda Balbirnie, Marcin Apostol, Jed Wiltzius,
Heather McFarlane, Anders O. Madsen, Christian Riekel, David Eisenberg.
protein
|
3D interactive demo
(jmol)
|
coordinates
|
movie/reference
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Insulin
(human) |
 |
asymmetric unit
|
partial pitch length
|
full pitch length
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morph between globular and fibrilar insulin
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Islet Amyloid Polypeptide
(human) |
 |
asymmetric unit
|
partial pitch length
|
|
Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D. Protein Sci.
2008 Sep;17(9):1467-74 |
RNase
(bovine, engineered) |
 |
asymmetric unit
|
partial pitch length
|
full pitch length
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Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure.
Sambashivan S, Liu Y, Sawaya MR, Gingery M, Eisenberg D. Nature.
2005 Sep 8;437(7056):266-9. |
beta2 microglobulin
(human) |
 |
asymmetric unit
|
partial pitch length
|
full pitch length plus
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An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril.
Ivanova MI, Sawaya MR, Gingery M, Attinger A, Eisenberg D. Proc Natl Acad Sci U S A.
2004 Jul 20;101(29):10584-9.
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Prion Protein
(human) |
 |
asymmetric unit
|
partial pitch length
|
full pitch length
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Seeded conversion of recombinant prion protein to a disulfide-bonded oligomer by a reduction-oxidation process. Lee S, Eisenberg D. Nat Struct Biol.
2003 Sep;10(9):725-30.
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