cog_id cog_name description category 1 COG0001 Glutamate-1-semialdehyde aminotransferase H 2 COG0002 Acetylglutamate semialdehyde dehydrogenase E 3 COG0003 Oxyanion-translocating ATPase P 4 COG0004 Ammonia permease P 5 COG0005 Purine nucleoside phosphorylase F 6 COG0006 Xaa-Pro aminopeptidase E 7 COG0007 Uroporphyrinogen-III methylase H 8 COG0008 Glutamyl- and glutaminyl-tRNA synthetases J 9 COG0009 Putative translation factor (SUA5) J 10 COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family E 11 COG0011 Uncharacterized conserved protein S 12 COG0012 Predicted GTPase, probable translation factor J 13 COG0013 Alanyl-tRNA synthetase J 14 COG0014 Gamma-glutamyl phosphate reductase E 15 COG0015 Adenylosuccinate lyase F 16 COG0016 Phenylalanyl-tRNA synthetase alpha subunit J 17 COG0017 Aspartyl/asparaginyl-tRNA synthetases J 18 COG0018 Arginyl-tRNA synthetase J 19 COG0019 Diaminopimelate decarboxylase E 20 COG0020 Undecaprenyl pyrophosphate synthase I 21 COG0021 Transketolase G 22 COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit C 23 COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins J 24 COG0024 Methionine aminopeptidase J 25 COG0025 NhaP-type Na+/H+ and K+/H+ antiporters P 26 COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) F 27 COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) F 28 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] E,H 29 COG0029 Aspartate oxidase H 30 COG0030 Dimethyladenosine transferase (rRNA methylation) J 31 COG0031 Cysteine synthase E 32 COG0033 Phosphoglucomutase G 33 COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase F 34 COG0035 Uracil phosphoribosyltransferase F 35 COG0036 Pentose-5-phosphate-3-epimerase G 36 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control D 37 COG0038 Chloride channel protein EriC P 38 COG0039 Malate/lactate dehydrogenases C 39 COG0040 ATP phosphoribosyltransferase E 40 COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase F 41 COG0042 tRNA-dihydrouridine synthase J 42 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases H 43 COG0044 Dihydroorotase and related cyclic amidohydrolases F 44 COG0045 Succinyl-CoA synthetase, beta subunit C 45 COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain F 46 COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain F 47 COG0048 Ribosomal protein S12 J 48 COG0049 Ribosomal protein S7 J 49 COG0050 GTPases - translation elongation factors J 50 COG0051 Ribosomal protein S10 J 51 COG0052 Ribosomal protein S2 J 52 COG0053 Predicted Co/Zn/Cd cation transporters P 53 COG0054 Riboflavin synthase beta-chain H 54 COG0055 F0F1-type ATP synthase, beta subunit C 55 COG0056 F0F1-type ATP synthase, alpha subunit C 56 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase G 57 COG0058 Glucan phosphorylase G 58 COG0059 Ketol-acid reductoisomerase E,H 59 COG0060 Isoleucyl-tRNA synthetase J 60 COG0061 Predicted sugar kinase G 61 COG0062 Uncharacterized conserved protein S 62 COG0063 Predicted sugar kinase G 63 COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) J 64 COG0065 3-isopropylmalate dehydratase large subunit E 65 COG0066 3-isopropylmalate dehydratase small subunit E 66 COG0067 Glutamate synthase domain 1 E 67 COG0068 Hydrogenase maturation factor O 68 COG0069 Glutamate synthase domain 2 E 69 COG0070 Glutamate synthase domain 3 E 70 COG0071 Molecular chaperone (small heat shock protein) O 71 COG0072 Phenylalanyl-tRNA synthetase beta subunit J 72 COG0073 EMAP domain R 73 COG0074 Succinyl-CoA synthetase, alpha subunit C 74 COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase E 75 COG0076 Glutamate decarboxylase and related PLP-dependent proteins E 76 COG0077 Prephenate dehydratase E 77 COG0078 Ornithine carbamoyltransferase E 78 COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase E 79 COG0080 Ribosomal protein L11 J 80 COG0081 Ribosomal protein L1 J 81 COG0082 Chorismate synthase E 82 COG0083 Homoserine kinase E 83 COG0084 Mg-dependent DNase L 84 COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit K 85 COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit K 86 COG0087 Ribosomal protein L3 J 87 COG0088 Ribosomal protein L4 J 88 COG0089 Ribosomal protein L23 J 89 COG0090 Ribosomal protein L2 J 90 COG0091 Ribosomal protein L22 J 91 COG0092 Ribosomal protein S3 J 92 COG0093 Ribosomal protein L14 J 93 COG0094 Ribosomal protein L5 J 94 COG0095 Lipoate-protein ligase A H 95 COG0096 Ribosomal protein S8 J 96 COG0097 Ribosomal protein L6P/L9E J 97 COG0098 Ribosomal protein S5 J 98 COG0099 Ribosomal protein S13 J 99 COG0100 Ribosomal protein S11 J 100 COG0101 Pseudouridylate synthase J 101 COG0102 Ribosomal protein L13 J 102 COG0103 Ribosomal protein S9 J 103 COG0104 Adenylosuccinate synthase F 104 COG0105 Nucleoside diphosphate kinase F 105 COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase E 106 COG0107 Imidazoleglycerol-phosphate synthase E 107 COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase H 108 COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor) O 109 COG0110 Acetyltransferase (isoleucine patch superfamily) R 110 COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases E,H 111 COG0112 Glycine/serine hydroxymethyltransferase E 112 COG0113 Delta-aminolevulinic acid dehydratase H 113 COG0114 Fumarase C 114 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase E,H 115 COG0116 Predicted N6-adenine-specific DNA methylase L 116 COG0117 Pyrimidine deaminase H 117 COG0118 Glutamine amidotransferase E 118 COG0119 Isopropylmalate/homocitrate/citramalate synthases E 119 COG0120 Ribose 5-phosphate isomerase G 120 COG0121 Predicted glutamine amidotransferase R 121 COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase L 122 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein B,Q 123 COG0124 Histidyl-tRNA synthetase J 124 COG0125 Thymidylate kinase F 125 COG0126 3-phosphoglycerate kinase G 126 COG0127 Xanthosine triphosphate pyrophosphatase F 127 COG0128 5-enolpyruvylshikimate-3-phosphate synthase E 128 COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase G,E 129 COG0130 Pseudouridine synthase J 130 COG0131 Imidazoleglycerol-phosphate dehydratase E 131 COG0132 Dethiobiotin synthetase H 132 COG0133 Tryptophan synthase beta chain E 133 COG0134 Indole-3-glycerol phosphate synthase E 134 COG0135 Phosphoribosylanthranilate isomerase E 135 COG0136 Aspartate-semialdehyde dehydrogenase E 136 COG0137 Argininosuccinate synthase E 137 COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) F 138 COG0139 Phosphoribosyl-AMP cyclohydrolase E 139 COG0140 Phosphoribosyl-ATP pyrophosphohydrolase E 140 COG0141 Histidinol dehydrogenase E 141 COG0142 Geranylgeranyl pyrophosphate synthase H 142 COG0143 Methionyl-tRNA synthetase J 143 COG0144 tRNA and rRNA cytosine-C5-methylases J 144 COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit E,Q 145 COG0146 N-methylhydantoinase B/acetone carboxylase, alpha subunit E,Q 146 COG0147 Anthranilate/para-aminobenzoate synthases component I E,H 147 COG0148 Enolase G 148 COG0149 Triosephosphate isomerase G 149 COG0150 Phosphoribosylaminoimidazole (AIR) synthetase F 150 COG0151 Phosphoribosylamine-glycine ligase F 151 COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase F 152 COG0153 Galactokinase G 153 COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases J 154 COG0155 Sulfite reductase, beta subunit (hemoprotein) P 155 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes H 156 COG0157 Nicotinate-nucleotide pyrophosphorylase H 157 COG0158 Fructose-1,6-bisphosphatase G 158 COG0159 Tryptophan synthase alpha chain E 159 COG0160 4-aminobutyrate aminotransferase and related aminotransferases E 160 COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase H 161 COG0162 Tyrosyl-tRNA synthetase J 162 COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase H 163 COG0164 Ribonuclease HII L 164 COG0165 Argininosuccinate lyase E 165 COG0166 Glucose-6-phosphate isomerase G 166 COG0167 Dihydroorotate dehydrogenase F 167 COG0168 Trk-type K+ transport systems, membrane components P 168 COG0169 Shikimate 5-dehydrogenase E 169 COG0170 Dolichol kinase I 170 COG0171 NAD synthase H 171 COG0172 Seryl-tRNA synthetase J 172 COG0173 Aspartyl-tRNA synthetase J 173 COG0174 Glutamine synthetase E 174 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes E,H 175 COG0176 Transaldolase G 176 COG0177 Predicted EndoIII-related endonuclease L 177 COG0178 Excinuclease ATPase subunit L 178 COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Q 179 COG0180 Tryptophanyl-tRNA synthetase J 180 COG0181 Porphobilinogen deaminase H 181 COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family J 182 COG0183 Acetyl-CoA acetyltransferase I 183 COG0184 Ribosomal protein S15P/S13E J 184 COG0185 Ribosomal protein S19 J 185 COG0186 Ribosomal protein S17 J 186 COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit L 187 COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit L 188 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) J,H 189 COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase H 190 COG0191 Fructose/tagatose bisphosphate aldolase G 191 COG0192 S-adenosylmethionine synthetase H 192 COG0193 Peptidyl-tRNA hydrolase J 193 COG0194 Guanylate kinase F 194 COG0195 Transcription elongation factor K 195 COG0196 FAD synthase H 196 COG0197 Ribosomal protein L16/L10E J 197 COG0198 Ribosomal protein L24 J 198 COG0199 Ribosomal protein S14 J 199 COG0200 Ribosomal protein L15 J 200 COG0201 Preprotein translocase subunit SecY U 201 COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit K 202 COG0203 Ribosomal protein L17 J 203 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase I 204 COG0205 6-phosphofructokinase G 205 COG0206 Cell division GTPase D 206 COG0207 Thymidylate synthase F 207 COG0208 Ribonucleotide reductase, beta subunit F 208 COG0209 Ribonucleotide reductase, alpha subunit F 209 COG0210 Superfamily I DNA and RNA helicases L 210 COG0211 Ribosomal protein L27 J 211 COG0212 5-formyltetrahydrofolate cyclo-ligase H 212 COG0213 Thymidine phosphorylase F 213 COG0214 Pyridoxine biosynthesis enzyme H 214 COG0215 Cysteinyl-tRNA synthetase J 215 COG0216 Protein chain release factor A J 216 COG0217 Uncharacterized conserved protein S 217 COG0218 Predicted GTPase R 218 COG0219 Predicted rRNA methylase (SpoU class) J 219 COG0220 Predicted S-adenosylmethionine-dependent methyltransferase R 220 COG0221 Inorganic pyrophosphatase C 221 COG0222 Ribosomal protein L7/L12 J 222 COG0223 Methionyl-tRNA formyltransferase J 223 COG0224 F0F1-type ATP synthase, gamma subunit C 224 COG0225 Peptide methionine sulfoxide reductase O 225 COG0226 ABC-type phosphate transport system, periplasmic component P 226 COG0227 Ribosomal protein L28 J 227 COG0228 Ribosomal protein S16 J 228 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase O 229 COG0230 Ribosomal protein L34 J 230 COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) J 231 COG0232 dGTP triphosphohydrolase F 232 COG0233 Ribosome recycling factor J 233 COG0234 Co-chaperonin GroES (HSP10) O 234 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases G 235 COG0236 Acyl carrier protein I,Q 236 COG0237 Dephospho-CoA kinase H 237 COG0238 Ribosomal protein S18 J 238 COG0239 Integral membrane protein possibly involved in chromosome condensation D 239 COG0240 Glycerol-3-phosphate dehydrogenase C 240 COG0241 Histidinol phosphatase and related phosphatases E 241 COG0242 N-formylmethionyl-tRNA deformylase J 242 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing C 243 COG0244 Ribosomal protein L10 J 244 COG0245 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase I 245 COG0246 Mannitol-1-phosphate/altronate dehydrogenases G 246 COG0247 Fe-S oxidoreductase C 247 COG0248 Exopolyphosphatase P,F 248 COG0249 Mismatch repair ATPase (MutS family) L 249 COG0250 Transcription antiterminator K 250 COG0251 Putative translation initiation inhibitor, yjgF family J 251 COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D J,E 252 COG0253 Diaminopimelate epimerase E 253 COG0254 Ribosomal protein L31 J 254 COG0255 Ribosomal protein L29 J 255 COG0256 Ribosomal protein L18 J 256 COG0257 Ribosomal protein L36 J 257 COG0258 5'-3' exonuclease (including N-terminal domain of PolI) L 258 COG0259 Pyridoxamine-phosphate oxidase H 259 COG0260 Leucyl aminopeptidase E 260 COG0261 Ribosomal protein L21 J 261 COG0262 Dihydrofolate reductase H 262 COG0263 Glutamate 5-kinase E 263 COG0264 Translation elongation factor Ts J 264 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain O 265 COG0266 Formamidopyrimidine-DNA glycosylase L 266 COG0267 Ribosomal protein L33 J 267 COG0268 Ribosomal protein S20 J 268 COG0269 3-hexulose-6-phosphate synthase and related proteins G 269 COG0270 Site-specific DNA methylase L 270 COG0271 Stress-induced morphogen (activity unknown) T 271 COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) L 272 COG0274 Deoxyribose-phosphate aldolase F 273 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis M 274 COG0276 Protoheme ferro-lyase (ferrochelatase) H 275 COG0277 FAD/FMN-containing dehydrogenases C 276 COG0278 Glutaredoxin-related protein O 277 COG0279 Phosphoheptose isomerase G 278 COG0280 Phosphotransacetylase C 279 COG0281 Malic enzyme C 280 COG0282 Acetate kinase C 281 COG0283 Cytidylate kinase F 282 COG0284 Orotidine-5'-phosphate decarboxylase F 283 COG0285 Folylpolyglutamate synthase H 284 COG0286 Type I restriction-modification system methyltransferase subunit V 285 COG0287 Prephenate dehydrogenase E 286 COG0288 Carbonic anhydrase P 287 COG0289 Dihydrodipicolinate reductase E 288 COG0290 Translation initiation factor 3 (IF-3) J 289 COG0291 Ribosomal protein L35 J 290 COG0292 Ribosomal protein L20 J 291 COG0293 23S rRNA methylase J 292 COG0294 Dihydropteroate synthase and related enzymes H 293 COG0295 Cytidine deaminase F 294 COG0296 1,4-alpha-glucan branching enzyme G 295 COG0297 Glycogen synthase G 296 COG0298 Hydrogenase maturation factor O 297 COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN F 298 COG0300 Short-chain dehydrogenases of various substrate specificities R 299 COG0301 Thiamine biosynthesis ATP pyrophosphatase H 300 COG0302 GTP cyclohydrolase I H 301 COG0303 Molybdopterin biosynthesis enzyme H 302 COG0304 3-oxoacyl-(acyl-carrier-protein) synthase I,Q 303 COG0305 Replicative DNA helicase L 304 COG0306 Phosphate/sulphate permeases P 305 COG0307 Riboflavin synthase alpha chain H 306 COG0308 Aminopeptidase N E 307 COG0309 Hydrogenase maturation factor O 308 COG0310 ABC-type Co2+ transport system, permease component P 309 COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis H 310 COG0312 Predicted Zn-dependent proteases and their inactivated homologs R 311 COG0313 Predicted methyltransferases R 312 COG0314 Molybdopterin converting factor, large subunit H 313 COG0315 Molybdenum cofactor biosynthesis enzyme H 314 COG0316 Uncharacterized conserved protein S 315 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases K,T 316 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II I,Q 317 COG0319 Predicted metal-dependent hydrolase R 318 COG0320 Lipoate synthase H 319 COG0321 Lipoate-protein ligase B H 320 COG0322 Nuclease subunit of the excinuclease complex L 321 COG0323 DNA mismatch repair enzyme (predicted ATPase) L 322 COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase J 323 COG0325 Predicted enzyme with a TIM-barrel fold R 324 COG0326 Molecular chaperone, HSP90 family O 325 COG0327 Uncharacterized conserved protein S 326 COG0328 Ribonuclease HI L 327 COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase M,E 328 COG0330 Membrane protease subunits, stomatin/prohibitin homologs O 329 COG0331 (acyl-carrier-protein) S-malonyltransferase I 330 COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III I 331 COG0333 Ribosomal protein L32 J 332 COG0334 Glutamate dehydrogenase/leucine dehydrogenase E 333 COG0335 Ribosomal protein L19 J 334 COG0336 tRNA-(guanine-N1)-methyltransferase J 335 COG0337 3-dehydroquinate synthetase E 336 COG0338 Site-specific DNA methylase L 337 COG0339 Zn-dependent oligopeptidases E 338 COG0340 Biotin-(acetyl-CoA carboxylase) ligase H 339 COG0341 Preprotein translocase subunit SecF U 340 COG0342 Preprotein translocase subunit SecD U 341 COG0343 Queuine/archaeosine tRNA-ribosyltransferase J 342 COG0344 Predicted membrane protein S 343 COG0345 Pyrroline-5-carboxylate reductase E 344 COG0346 Lactoylglutathione lyase and related lyases E 345 COG0347 Nitrogen regulatory protein PII E 346 COG0348 Polyferredoxin C 347 COG0349 Ribonuclease D J 348 COG0350 Methylated DNA-protein cysteine methyltransferase L 349 COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase H 350 COG0352 Thiamine monophosphate synthase H 351 COG0353 Recombinational DNA repair protein (RecF pathway) L 352 COG0354 Predicted aminomethyltransferase related to GcvT R 353 COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) C 354 COG0356 F0F1-type ATP synthase, subunit a C 355 COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division M 356 COG0358 DNA primase (bacterial type) L 357 COG0359 Ribosomal protein L9 J 358 COG0360 Ribosomal protein S6 J 359 COG0361 Translation initiation factor 1 (IF-1) J 360 COG0362 6-phosphogluconate dehydrogenase G 361 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase G 362 COG0364 Glucose-6-phosphate 1-dehydrogenase G 363 COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases I 364 COG0366 Glycosidases G 365 COG0367 Asparagine synthase (glutamine-hydrolyzing) E 366 COG0368 Cobalamin-5-phosphate synthase H 367 COG0369 Sulfite reductase, alpha subunit (flavoprotein) P 368 COG0370 Fe2+ transport system protein B P 369 COG0371 Glycerol dehydrogenase and related enzymes C 370 COG0372 Citrate synthase C 371 COG0373 Glutamyl-tRNA reductase H 372 COG0374 Ni,Fe-hydrogenase I large subunit C 373 COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) R 374 COG0376 Catalase (peroxidase I) P 375 COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases C 376 COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase K,O 377 COG0379 Quinolinate synthase H 378 COG0380 Trehalose-6-phosphate synthase G 379 COG0381 UDP-N-acetylglucosamine 2-epimerase M 380 COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases H 381 COG0383 Alpha-mannosidase G 382 COG0384 Predicted epimerase, PhzC/PhzF homolog R 383 COG0385 Predicted Na+-dependent transporter R 384 COG0386 Glutathione peroxidase O 385 COG0387 Ca2+/H+ antiporter P 386 COG0388 Predicted amidohydrolase R 387 COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair L 388 COG0390 ABC-type uncharacterized transport system, permease component R 389 COG0391 Uncharacterized conserved protein S 390 COG0392 Predicted integral membrane protein S 391 COG0393 Uncharacterized conserved protein S 392 COG0394 Protein-tyrosine-phosphatase T 393 COG0395 ABC-type sugar transport system, permease component G 394 COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component O 395 COG0397 Uncharacterized conserved protein S 396 COG0398 Uncharacterized conserved protein S 397 COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis M 398 COG0400 Predicted esterase R 399 COG0401 Uncharacterized homolog of Blt101 S 400 COG0402 Cytosine deaminase and related metal-dependent hydrolases F,R 401 COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain E 402 COG0404 Glycine cleavage system T protein (aminomethyltransferase) E 403 COG0405 Gamma-glutamyltransferase E 404 COG0406 Fructose-2,6-bisphosphatase G 405 COG0407 Uroporphyrinogen-III decarboxylase H 406 COG0408 Coproporphyrinogen III oxidase H 407 COG0409 Hydrogenase maturation factor O 408 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component E 409 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component E 410 COG0412 Dienelactone hydrolase and related enzymes Q 411 COG0413 Ketopantoate hydroxymethyltransferase H 412 COG0414 Panthothenate synthetase H 413 COG0415 Deoxyribodipyrimidine photolyase L 414 COG0416 Fatty acid/phospholipid biosynthesis enzyme I 415 COG0417 DNA polymerase elongation subunit (family B) L 416 COG0418 Dihydroorotase F 417 COG0419 ATPase involved in DNA repair L 418 COG0420 DNA repair exonuclease L 419 COG0421 Spermidine synthase E 420 COG0422 Thiamine biosynthesis protein ThiC H 421 COG0423 Glycyl-tRNA synthetase (class II) J 422 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation D 423 COG0425 Predicted redox protein, regulator of disulfide bond formation O 424 COG0426 Uncharacterized flavoproteins C 425 COG0427 Acetyl-CoA hydrolase C 426 COG0428 Predicted divalent heavy-metal cations transporter P 427 COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold R 428 COG0430 RNA 3'-terminal phosphate cyclase A 429 COG0431 Predicted flavoprotein R 430 COG0432 Uncharacterized conserved protein S 431 COG0433 Predicted ATPase R 432 COG0434 Predicted TIM-barrel enzyme R 433 COG0435 Predicted glutathione S-transferase O 434 COG0436 Aspartate/tyrosine/aromatic aminotransferase E 435 COG0437 Fe-S-cluster-containing hydrogenase components 1 C 436 COG0438 Glycosyltransferase M 437 COG0439 Biotin carboxylase I 438 COG0440 Acetolactate synthase, small (regulatory) subunit E 439 COG0441 Threonyl-tRNA synthetase J 440 COG0442 Prolyl-tRNA synthetase J 441 COG0443 Molecular chaperone O 442 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component P,E 443 COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division D 444 COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases R 445 COG0447 Dihydroxynaphthoic acid synthase H 446 COG0448 ADP-glucose pyrophosphorylase G 447 COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains M 448 COG0450 Peroxiredoxin O 449 COG0451 Nucleoside-diphosphate-sugar epimerases M,G 450 COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase H 451 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K,R 452 COG0455 ATPases involved in chromosome partitioning D 453 COG0456 Acetyltransferases R 454 COG0457 FOG: TPR repeat R 455 COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) E,F 456 COG0459 Chaperonin GroEL (HSP60 family) O 457 COG0460 Homoserine dehydrogenase E 458 COG0461 Orotate phosphoribosyltransferase F 459 COG0462 Phosphoribosylpyrophosphate synthetase E,F 460 COG0463 Glycosyltransferases involved in cell wall biogenesis M 461 COG0464 ATPases of the AAA+ class O 462 COG0465 ATP-dependent Zn proteases O 463 COG0466 ATP-dependent Lon protease, bacterial type O 464 COG0467 RecA-superfamily ATPases implicated in signal transduction T 465 COG0468 RecA/RadA recombinase L 466 COG0469 Pyruvate kinase G 467 COG0470 ATPase involved in DNA replication L 468 COG0471 Di- and tricarboxylate transporters P 469 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase M 470 COG0473 Isocitrate/isopropylmalate dehydrogenase C,E 471 COG0474 Cation transport ATPase P 472 COG0475 Kef-type K+ transport systems, membrane components P 473 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 H 474 COG0477 Permeases of the major facilitator superfamily P,G,E,R 475 COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain T 476 COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit C 477 COG0480 Translation elongation factors (GTPases) J 478 COG0481 Membrane GTPase LepA M 479 COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain J 480 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family G 481 COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain O 482 COG0486 Predicted GTPase R 483 COG0488 ATPase components of ABC transporters with duplicated ATPase domains R 484 COG0489 ATPases involved in chromosome partitioning D 485 COG0490 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels P 486 COG0491 Zn-dependent hydrolases, including glyoxylases R 487 COG0492 Thioredoxin reductase O 488 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases E,R 489 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes L,R 490 COG0495 Leucyl-tRNA synthetase J 491 COG0496 Predicted acid phosphatase R 492 COG0497 ATPase involved in DNA repair L 493 COG0498 Threonine synthase E 494 COG0499 S-adenosylhomocysteine hydrolase H 495 COG0500 SAM-dependent methyltransferases Q,R 496 COG0501 Zn-dependent protease with chaperone function O 497 COG0502 Biotin synthase and related enzymes H 498 COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins F 499 COG0504 CTP synthase (UTP-ammonia lyase) F 500 COG0505 Carbamoylphosphate synthase small subunit E,F 501 COG0506 Proline dehydrogenase E 502 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member L 503 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes C 504 COG0509 Glycine cleavage system H protein (lipoate-binding) E 505 COG0510 Predicted choline kinase involved in LPS biosynthesis M 506 COG0511 Biotin carboxyl carrier protein I 507 COG0512 Anthranilate/para-aminobenzoate synthases component II E,H 508 COG0513 Superfamily II DNA and RNA helicases J,K,L 509 COG0514 Superfamily II DNA helicase L 510 COG0515 Serine/threonine protein kinase K,L,T,R 511 COG0516 IMP dehydrogenase/GMP reductase F 512 COG0517 FOG: CBS domain R 513 COG0518 GMP synthase - Glutamine amidotransferase domain F 514 COG0519 GMP synthase, PP-ATPase domain/subunit F 515 COG0520 Selenocysteine lyase E 516 COG0521 Molybdopterin biosynthesis enzymes H 517 COG0522 Ribosomal protein S4 and related proteins J 518 COG0523 Putative GTPases (G3E family) R 519 COG0524 Sugar kinases, ribokinase family G 520 COG0525 Valyl-tRNA synthetase J 521 COG0526 Thiol-disulfide isomerase and thioredoxins O,C 522 COG0527 Aspartokinases E 523 COG0528 Uridylate kinase F 524 COG0529 Adenylylsulfate kinase and related kinases P 525 COG0530 Ca2+/Na+ antiporter P 526 COG0531 Amino acid transporters E 527 COG0532 Translation initiation factor 2 (IF-2; GTPase) J 528 COG0533 Metal-dependent proteases with possible chaperone activity O 529 COG0534 Na+-driven multidrug efflux pump V 530 COG0535 Predicted Fe-S oxidoreductases R 531 COG0536 Predicted GTPase R 532 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases G,F,R 533 COG0538 Isocitrate dehydrogenases C 534 COG0539 Ribosomal protein S1 J 535 COG0540 Aspartate carbamoyltransferase, catalytic chain F 536 COG0541 Signal recognition particle GTPase U 537 COG0542 ATPases with chaperone activity, ATP-binding subunit O 538 COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases C,H 539 COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) O 540 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 O 541 COG0546 Predicted phosphatases R 542 COG0547 Anthranilate phosphoribosyltransferase E 543 COG0548 Acetylglutamate kinase E 544 COG0549 Carbamate kinase E 545 COG0550 Topoisomerase IA L 546 COG0551 Zn-finger domain associated with topoisomerase type I L 547 COG0552 Signal recognition particle GTPase U 548 COG0553 Superfamily II DNA/RNA helicases, SNF2 family K,L 549 COG0554 Glycerol kinase C 550 COG0555 ABC-type sulfate transport system, permease component O 551 COG0556 Helicase subunit of the DNA excision repair complex L 552 COG0557 Exoribonuclease R K 553 COG0558 Phosphatidylglycerophosphate synthase I 554 COG0559 Branched-chain amino acid ABC-type transport system, permease components E 555 COG0560 Phosphoserine phosphatase E 556 COG0561 Predicted hydrolases of the HAD superfamily R 557 COG0562 UDP-galactopyranose mutase M 558 COG0563 Adenylate kinase and related kinases F 559 COG0564 Pseudouridylate synthases, 23S RNA-specific J 560 COG0565 rRNA methylase J 561 COG0566 rRNA methylases J 562 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes C 563 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) K 564 COG0569 K+ transport systems, NAD-binding component P 565 COG0571 dsRNA-specific ribonuclease K 566 COG0572 Uridine kinase F 567 COG0573 ABC-type phosphate transport system, permease component P 568 COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase G 569 COG0575 CDP-diglyceride synthetase I 570 COG0576 Molecular chaperone GrpE (heat shock protein) O 571 COG0577 ABC-type antimicrobial peptide transport system, permease component V 572 COG0578 Glycerol-3-phosphate dehydrogenase C 573 COG0579 Predicted dehydrogenase R 574 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) G 575 COG0581 ABC-type phosphate transport system, permease component P 576 COG0582 Integrase L 577 COG0583 Transcriptional regulator K 578 COG0584 Glycerophosphoryl diester phosphodiesterase C 579 COG0585 Uncharacterized conserved protein S 580 COG0586 Uncharacterized membrane-associated protein S 581 COG0587 DNA polymerase III, alpha subunit L 582 COG0588 Phosphoglycerate mutase 1 G 583 COG0589 Universal stress protein UspA and related nucleotide-binding proteins T 584 COG0590 Cytosine/adenosine deaminases J,F 585 COG0591 Na+/proline symporter E,R 586 COG0592 DNA polymerase sliding clamp subunit (PCNA homolog) L 587 COG0593 ATPase involved in DNA replication initiation L 588 COG0594 RNase P protein component J 589 COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily R 590 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) R 591 COG0597 Lipoprotein signal peptidase U,M 592 COG0598 Mg2+ and Co2+ transporters P 593 COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit S 594 COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component P 595 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components P,E 596 COG0602 Organic radical activating enzymes O 597 COG0603 Predicted PP-loop superfamily ATPase R 598 COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases C,R 599 COG0605 Superoxide dismutase P 600 COG0606 Predicted ATPase with chaperone activity O 601 COG0607 Rhodanese-related sulfurtransferase P 602 COG0608 Single-stranded DNA-specific exonuclease L 603 COG0609 ABC-type Fe3+-siderophore transport system, permease component P 604 COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases V 605 COG0611 Thiamine monophosphate kinase H 606 COG0612 Predicted Zn-dependent peptidases R 607 COG0613 Predicted metal-dependent phosphoesterases (PHP family) R 608 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component P 609 COG0615 Cytidylyltransferase M,I 610 COG0616 Periplasmic serine proteases (ClpP class) U,O 611 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase J 612 COG0618 Exopolyphosphatase-related proteins R 613 COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters P 614 COG0620 Methionine synthase II (cobalamin-independent) E 615 COG0621 2-methylthioadenine synthetase J 616 COG0622 Predicted phosphoesterase R 617 COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH) I 618 COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases E 619 COG0625 Glutathione S-transferase O 620 COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases E 621 COG0627 Predicted esterase R 622 COG0628 Predicted permease R 623 COG0629 Single-stranded DNA-binding protein L 624 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis U,N 625 COG0631 Serine/threonine protein phosphatase T 626 COG0632 Holliday junction resolvasome, DNA-binding subunit L 627 COG0633 Ferredoxin C 628 COG0634 Hypoxanthine-guanine phosphoribosyltransferase F 629 COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases H 630 COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K C 631 COG0637 Predicted phosphatase/phosphohexomutase R 632 COG0638 20S proteasome, alpha and beta subunits O 633 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases T 634 COG0640 Predicted transcriptional regulators K 635 COG0641 Arylsulfatase regulator (Fe-S oxidoreductase) R 636 COG0642 Signal transduction histidine kinase T 637 COG0643 Chemotaxis protein histidine kinase and related kinases N,T 638 COG0644 Dehydrogenases (flavoproteins) C 639 COG0645 Predicted kinase R 640 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain E 641 COG0647 Predicted sugar phosphatases of the HAD superfamily G 642 COG0648 Endonuclease IV L 643 COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 C 644 COG0650 Formate hydrogenlyase subunit 4 C 645 COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit P,C 646 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family O 647 COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase) U 648 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases C,H 649 COG0655 Multimeric flavodoxin WrbA R 650 COG0656 Aldo/keto reductases, related to diketogulonate reductase R 651 COG0657 Esterase/lipase I 652 COG0658 Predicted membrane metal-binding protein R 653 COG0659 Sulfate permease and related transporters (MFS superfamily) P 654 COG0661 Predicted unusual protein kinase R 655 COG0662 Mannose-6-phosphate isomerase G 656 COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily R 657 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases T 658 COG0665 Glycine/D-amino acid oxidases (deaminating) E 659 COG0666 FOG: Ankyrin repeat R 660 COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) C 661 COG0668 Small-conductance mechanosensitive channel M 662 COG0669 Phosphopantetheine adenylyltransferase H 663 COG0670 Integral membrane protein, interacts with FtsH R 664 COG0671 Membrane-associated phospholipid phosphatase I 665 COG0672 High-affinity Fe2+/Pb2+ permease P 666 COG0673 Predicted dehydrogenases and related proteins R 667 COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit C 668 COG0675 Transposase and inactivated derivatives L 669 COG0676 Uncharacterized enzymes related to aldose 1-epimerase G 670 COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase M 671 COG0678 Peroxiredoxin O 672 COG0679 Predicted permeases R 673 COG0680 Ni,Fe-hydrogenase maturation factor C 674 COG0681 Signal peptidase I U 675 COG0682 Prolipoprotein diacylglyceryltransferase M 676 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component E 677 COG0684 Demethylmenaquinone methyltransferase H 678 COG0685 5,10-methylenetetrahydrofolate reductase E 679 COG0686 Alanine dehydrogenase E 680 COG0687 Spermidine/putrescine-binding periplasmic protein E 681 COG0688 Phosphatidylserine decarboxylase I 682 COG0689 RNase PH J 683 COG0690 Preprotein translocase subunit SecE U 684 COG0691 tmRNA-binding protein O 685 COG0692 Uracil DNA glycosylase L 686 COG0693 Putative intracellular protease/amidase R 687 COG0694 Thioredoxin-like proteins and domains O 688 COG0695 Glutaredoxin and related proteins O 689 COG0696 Phosphoglyceromutase G 690 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily G,E,R 691 COG0698 Ribose 5-phosphate isomerase RpiB G 692 COG0699 Predicted GTPases (dynamin-related) R 693 COG0700 Uncharacterized membrane protein S 694 COG0701 Predicted permeases R 695 COG0702 Predicted nucleoside-diphosphate-sugar epimerases M,G 696 COG0703 Shikimate kinase E 697 COG0704 Phosphate uptake regulator P 698 COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) R 699 COG0706 Preprotein translocase subunit YidC U 700 COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase M 701 COG0708 Exonuclease III L 702 COG0709 Selenophosphate synthase E 703 COG0710 3-dehydroquinate dehydratase E 704 COG0711 F0F1-type ATP synthase, subunit b C 705 COG0712 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) C 706 COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) C 707 COG0714 MoxR-like ATPases R 708 COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components P 709 COG0716 Flavodoxins C 710 COG0717 Deoxycytidine deaminase F 711 COG0718 Uncharacterized protein conserved in bacteria S 712 COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component O 713 COG0720 6-pyruvoyl-tetrahydropterin synthase H 714 COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit J 715 COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase E 716 COG0723 Rieske Fe-S protein C 717 COG0724 RNA-binding proteins (RRM domain) R 718 COG0725 ABC-type molybdate transport system, periplasmic component P 719 COG0726 Predicted xylanase/chitin deacetylase G 720 COG0727 Predicted Fe-S-cluster oxidoreductase R 721 COG0728 Uncharacterized membrane protein, putative virulence factor R 722 COG0729 Outer membrane protein M 723 COG0730 Predicted permeases R 724 COG0731 Fe-S oxidoreductases C 725 COG0732 Restriction endonuclease S subunits V 726 COG0733 Na+-dependent transporters of the SNF family R 727 COG0735 Fe2+/Zn2+ uptake regulation proteins P 728 COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) I 729 COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases F 730 COG0738 Fucose permease G 731 COG0739 Membrane proteins related to metalloendopeptidases M 732 COG0740 Protease subunit of ATP-dependent Clp proteases U,O 733 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) M 734 COG0742 N6-adenine-specific methylase L 735 COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase I 736 COG0744 Membrane carboxypeptidase (penicillin-binding protein) M 737 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K,T 738 COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A H 739 COG0747 ABC-type dipeptide transport system, periplasmic component E 740 COG0748 Putative heme iron utilization protein P 741 COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains L 742 COG0750 Predicted membrane-associated Zn-dependent proteases 1 M 743 COG0751 Glycyl-tRNA synthetase, beta subunit J 744 COG0752 Glycyl-tRNA synthetase, alpha subunit J 745 COG0753 Catalase P 746 COG0754 Glutathionylspermidine synthase E 747 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component O 748 COG0756 dUTPase F 749 COG0757 3-dehydroquinate dehydratase II E 750 COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake L,U 751 COG0759 Uncharacterized conserved protein S 752 COG0760 Parvulin-like peptidyl-prolyl isomerase O 753 COG0761 Penicillin tolerance protein M,I 754 COG0762 Predicted integral membrane protein S 755 COG0763 Lipid A disaccharide synthetase M 756 COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases I 757 COG0765 ABC-type amino acid transport system, permease component E 758 COG0766 UDP-N-acetylglucosamine enolpyruvyl transferase M 759 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component Q 760 COG0768 Cell division protein FtsI/penicillin-binding protein 2 M 761 COG0769 UDP-N-acetylmuramyl tripeptide synthase M 762 COG0770 UDP-N-acetylmuramyl pentapeptide synthase M 763 COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase M 764 COG0772 Bacterial cell division membrane protein D 765 COG0773 UDP-N-acetylmuramate-alanine ligase M 766 COG0774 UDP-3-O-acyl-N-acetylglucosamine deacetylase M 767 COG0775 Nucleoside phosphorylase F 768 COG0776 Bacterial nucleoid DNA-binding protein L 769 COG0777 Acetyl-CoA carboxylase beta subunit I 770 COG0778 Nitroreductase C 771 COG0779 Uncharacterized protein conserved in bacteria S 772 COG0780 Enzyme related to GTP cyclohydrolase I R 773 COG0781 Transcription termination factor K 774 COG0782 Transcription elongation factor K 775 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) P 776 COG0784 FOG: CheY-like receiver T 777 COG0785 Cytochrome c biogenesis protein O 778 COG0786 Na+/glutamate symporter E 779 COG0787 Alanine racemase M 780 COG0788 Formyltetrahydrofolate hydrolase F 781 COG0789 Predicted transcriptional regulators K 782 COG0790 FOG: TPR repeat, SEL1 subfamily R 783 COG0791 Cell wall-associated hydrolases (invasion-associated proteins) M 784 COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase L 785 COG0793 Periplasmic protease M 786 COG0794 Predicted sugar phosphate isomerase involved in capsule formation M 787 COG0795 Predicted permeases R 788 COG0796 Glutamate racemase M 789 COG0797 Lipoproteins M 790 COG0798 Arsenite efflux pump ACR3 and related permeases P 791 COG0799 Uncharacterized homolog of plant Iojap protein S 792 COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase G 793 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase H 794 COG0802 Predicted ATPase or kinase R 795 COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin P 796 COG0804 Urea amidohydrolase (urease) alpha subunit E 797 COG0805 Sec-independent protein secretion pathway component TatC U 798 COG0806 RimM protein, required for 16S rRNA processing J 799 COG0807 GTP cyclohydrolase II H 800 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) J 801 COG0810 Periplasmic protein TonB, links inner and outer membranes M 802 COG0811 Biopolymer transport proteins U 803 COG0812 UDP-N-acetylmuramate dehydrogenase M 804 COG0813 Purine-nucleoside phosphorylase F 805 COG0814 Amino acid permeases E 806 COG0815 Apolipoprotein N-acyltransferase M 807 COG0816 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) L 808 COG0817 Holliday junction resolvasome, endonuclease subunit L 809 COG0818 Diacylglycerol kinase M 810 COG0819 Putative transcription activator K 811 COG0820 Predicted Fe-S-cluster redox enzyme R 812 COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis I 813 COG0822 NifU homolog involved in Fe-S cluster formation C 814 COG0823 Periplasmic component of the Tol biopolymer transport system U 815 COG0824 Predicted thioesterase R 816 COG0825 Acetyl-CoA carboxylase alpha subunit I 817 COG0826 Collagenase and related proteases O 818 COG0827 Adenine-specific DNA methylase L 819 COG0828 Ribosomal protein S21 J 820 COG0829 Urease accessory protein UreH O 821 COG0830 Urease accessory protein UreF O 822 COG0831 Urea amidohydrolase (urease) gamma subunit E 823 COG0832 Urea amidohydrolase (urease) beta subunit E 824 COG0833 Amino acid transporters E 825 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain T,E 826 COG0835 Chemotaxis signal transduction protein N,T 827 COG0836 Mannose-1-phosphate guanylyltransferase M 828 COG0837 Glucokinase G 829 COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A) C 830 COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) C 831 COG0840 Methyl-accepting chemotaxis protein N,T 832 COG0841 Cation/multidrug efflux pump V 833 COG0842 ABC-type multidrug transport system, permease component V 834 COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 C 835 COG0845 Membrane-fusion protein M 836 COG0846 NAD-dependent protein deacetylases, SIR2 family K 837 COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases L 838 COG0848 Biopolymer transport protein U 839 COG0849 Actin-like ATPase involved in cell division D 840 COG0850 Septum formation inhibitor D 841 COG0851 Septum formation topological specificity factor D 842 COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit C 843 COG0853 Aspartate 1-decarboxylase H 844 COG0854 Pyridoxal phosphate biosynthesis protein H 845 COG0855 Polyphosphate kinase P 846 COG0856 Orotate phosphoribosyltransferase homologs F 847 COG0857 BioD-like N-terminal domain of phosphotransacetylase R 848 COG0858 Ribosome-binding factor A J 849 COG0859 ADP-heptose:LPS heptosyltransferase M 850 COG0860 N-acetylmuramoyl-L-alanine amidase M 851 COG0861 Membrane protein TerC, possibly involved in tellurium resistance P 852 COG0863 DNA modification methylase L 853 COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain K 854 COG1001 Adenine deaminase F 855 COG1002 Type II restriction enzyme, methylase subunits V 856 COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain E 857 COG1004 Predicted UDP-glucose 6-dehydrogenase M 858 COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H) C 859 COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit P 860 COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N) C 861 COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M) C 862 COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit P,C 863 COG1010 Precorrin-3B methylase H 864 COG1011 Predicted hydrolase (HAD superfamily) R 865 COG1012 NAD-dependent aldehyde dehydrogenases C 866 COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit C 867 COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit C 868 COG1015 Phosphopentomutase G 869 COG1017 Hemoglobin-like flavoprotein C 870 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 C 871 COG1019 Predicted nucleotidyltransferase R 872 COG1020 Non-ribosomal peptide synthetase modules and related proteins Q 873 COG1021 Peptide arylation enzymes Q 874 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) I 875 COG1023 Predicted 6-phosphogluconate dehydrogenase G 876 COG1024 Enoyl-CoA hydratase/carnithine racemase I 877 COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like O 878 COG1026 Predicted Zn-dependent peptidases, insulinase-like R 879 COG1027 Aspartate ammonia-lyase E 880 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) I,Q,R 881 COG1029 Formylmethanofuran dehydrogenase subunit B C 882 COG1030 Membrane-bound serine protease (ClpP class) O 883 COG1031 Uncharacterized Fe-S oxidoreductase C 884 COG1032 Fe-S oxidoreductase C 885 COG1033 Predicted exporters of the RND superfamily R 886 COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) C 887 COG1035 Coenzyme F420-reducing hydrogenase, beta subunit C 888 COG1036 Archaeal flavoproteins C 889 COG1038 Pyruvate carboxylase C 890 COG1039 Ribonuclease HIII L 891 COG1040 Predicted amidophosphoribosyltransferases R 892 COG1041 Predicted DNA modification methylase L 893 COG1042 Acyl-CoA synthetase (NDP forming) C 894 COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase M 895 COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase M 896 COG1045 Serine acetyltransferase E 897 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 O 898 COG1048 Aconitase A C 899 COG1049 Aconitase B C 900 COG1051 ADP-ribose pyrophosphatase F 901 COG1052 Lactate dehydrogenase and related dehydrogenases C,H,R 902 COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit C 903 COG1054 Predicted sulfurtransferase R 904 COG1055 Na+/H+ antiporter NhaD and related arsenite permeases P 905 COG1056 Nicotinamide mononucleotide adenylyltransferase H 906 COG1057 Nicotinic acid mononucleotide adenylyltransferase H 907 COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA R 908 COG1059 Thermostable 8-oxoguanine DNA glycosylase L 909 COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes H,R 910 COG1061 DNA or RNA helicases of superfamily II K,L 911 COG1062 Zn-dependent alcohol dehydrogenases, class III C 912 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases E,R 913 COG1064 Zn-dependent alcohol dehydrogenases R 914 COG1066 Predicted ATP-dependent serine protease O 915 COG1067 Predicted ATP-dependent protease O 916 COG1069 Ribulose kinase C 917 COG1070 Sugar (pentulose and hexulose) kinases G 918 COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit C 919 COG1072 Panthothenate kinase H 920 COG1073 Hydrolases of the alpha/beta superfamily R 921 COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) L 922 COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold R 923 COG1076 DnaJ-domain-containing proteins 1 O 924 COG1077 Actin-like ATPase involved in cell morphogenesis D 925 COG1078 HD superfamily phosphohydrolases R 926 COG1079 Uncharacterized ABC-type transport system, permease component R 927 COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) G 928 COG1082 Sugar phosphate isomerases/epimerases G 929 COG1083 CMP-N-acetylneuraminic acid synthetase M 930 COG1084 Predicted GTPase R 931 COG1085 Galactose-1-phosphate uridylyltransferase C 932 COG1086 Predicted nucleoside-diphosphate sugar epimerases M,G 933 COG1087 UDP-glucose 4-epimerase M 934 COG1088 dTDP-D-glucose 4,6-dehydratase M 935 COG1089 GDP-D-mannose dehydratase M 936 COG1090 Predicted nucleoside-diphosphate sugar epimerase R 937 COG1091 dTDP-4-dehydrorhamnose reductase M 938 COG1092 Predicted SAM-dependent methyltransferases R 939 COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha) J 940 COG1094 Predicted RNA-binding protein (contains KH domains) R 941 COG1095 DNA-directed RNA polymerase, subunit E' K 942 COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) J 943 COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) J 944 COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain) J 945 COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold R 946 COG1100 GTPase SAR1 and related small G proteins R 947 COG1101 ABC-type uncharacterized transport system, ATPase component R 948 COG1102 Cytidylate kinase F 949 COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes R 950 COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes E 951 COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) G 952 COG1106 Predicted ATPases R 953 COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain L 954 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components P 955 COG1109 Phosphomannomutase G 956 COG1110 Reverse gyrase L 957 COG1111 ERCC4-like helicases L 958 COG1112 Superfamily I DNA and RNA helicases and helicase subunits L 959 COG1113 Gamma-aminobutyrate permease and related permeases E 960 COG1114 Branched-chain amino acid permeases E 961 COG1115 Na+/alanine symporter E 962 COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component P 963 COG1117 ABC-type phosphate transport system, ATPase component P 964 COG1118 ABC-type sulfate/molybdate transport systems, ATPase component P 965 COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA P 966 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components P,H 967 COG1121 ABC-type Mn/Zn transport systems, ATPase component P 968 COG1122 ABC-type cobalt transport system, ATPase component P 969 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase R 970 COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component P,E 971 COG1125 ABC-type proline/glycine betaine transport systems, ATPase components E 972 COG1126 ABC-type polar amino acid transport system, ATPase component E 973 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component Q 974 COG1129 ABC-type sugar transport system, ATPase component G 975 COG1131 ABC-type multidrug transport system, ATPase component V 976 COG1132 ABC-type multidrug transport system, ATPase and permease components V 977 COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components I 978 COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component M,G 979 COG1135 ABC-type metal ion transport system, ATPase component P 980 COG1136 ABC-type antimicrobial peptide transport system, ATPase component V 981 COG1137 ABC-type (unclassified) transport system, ATPase component R 982 COG1138 Cytochrome c biogenesis factor O 983 COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain C 984 COG1140 Nitrate reductase beta subunit C 985 COG1141 Ferredoxin C 986 COG1142 Fe-S-cluster-containing hydrogenase components 2 C 987 COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) C 988 COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit C 989 COG1145 Ferredoxin C 990 COG1146 Ferredoxin C 991 COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins C 992 COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain C 993 COG1150 Heterodisulfide reductase, subunit C C 994 COG1151 6Fe-6S prismane cluster-containing protein C 995 COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit C 996 COG1153 Formylmethanofuran dehydrogenase subunit D C 997 COG1154 Deoxyxylulose-5-phosphate synthase H,I 998 COG1155 Archaeal/vacuolar-type H+-ATPase subunit A C 999 COG1156 Archaeal/vacuolar-type H+-ATPase subunit B C 1000 COG1157 Flagellar biosynthesis/type III secretory pathway ATPase U,N 1001 COG1158 Transcription termination factor K 1002 COG1159 GTPase R 1003 COG1160 Predicted GTPases R 1004 COG1161 Predicted GTPases R 1005 COG1162 Predicted GTPases R 1006 COG1163 Predicted GTPase R 1007 COG1164 Oligoendopeptidase F E 1008 COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase H 1009 COG1166 Arginine decarboxylase (spermidine biosynthesis) E 1010 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K,E 1011 COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities E 1012 COG1169 Isochorismate synthase H,Q 1013 COG1171 Threonine dehydratase E 1014 COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components G 1015 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components P,E 1016 COG1174 ABC-type proline/glycine betaine transport systems, permease component E 1017 COG1175 ABC-type sugar transport systems, permease components G 1018 COG1176 ABC-type spermidine/putrescine transport system, permease component I E 1019 COG1177 ABC-type spermidine/putrescine transport system, permease component II E 1020 COG1178 ABC-type Fe3+ transport system, permease component P 1021 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 H 1022 COG1180 Pyruvate-formate lyase-activating enzyme O 1023 COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes M 1024 COG1182 Acyl carrier protein phosphodiesterase I 1025 COG1183 Phosphatidylserine synthase I 1026 COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family J 1027 COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) J 1028 COG1186 Protein chain release factor B J 1029 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases J 1030 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) J 1031 COG1189 Predicted rRNA methylase J 1032 COG1190 Lysyl-tRNA synthetase (class II) J 1033 COG1191 DNA-directed RNA polymerase specialized sigma subunit K 1034 COG1192 ATPases involved in chromosome partitioning D 1035 COG1193 Mismatch repair ATPase (MutS family) L 1036 COG1194 A/G-specific DNA glycosylase L 1037 COG1195 Recombinational DNA repair ATPase (RecF pathway) L 1038 COG1196 Chromosome segregation ATPases D 1039 COG1197 Transcription-repair coupling factor (superfamily II helicase) K,L 1040 COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase L 1041 COG1199 Rad3-related DNA helicases K,L 1042 COG1200 RecG-like helicase K,L 1043 COG1201 Lhr-like helicases R 1044 COG1202 Superfamily II helicase, archaea-specific R 1045 COG1203 Predicted helicases R 1046 COG1204 Superfamily II helicase R 1047 COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster R 1048 COG1206 NAD(FAD)-utilizing enzyme possibly involved in translation J 1049 COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) M 1050 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) J,M 1051 COG1209 dTDP-glucose pyrophosphorylase M 1052 COG1210 UDP-glucose pyrophosphorylase M 1053 COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase I 1054 COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase M 1055 COG1213 Predicted sugar nucleotidyltransferases M 1056 COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone O 1057 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis M 1058 COG1216 Predicted glycosyltransferases R 1059 COG1217 Predicted membrane GTPase involved in stress response T 1060 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase P 1061 COG1219 ATP-dependent protease Clp, ATPase subunit O 1062 COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit O 1063 COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain K,T 1064 COG1222 ATP-dependent 26S proteasome regulatory subunit O 1065 COG1223 Predicted ATPase (AAA+ superfamily) R 1066 COG1224 DNA helicase TIP49, TBP-interacting protein K 1067 COG1225 Peroxiredoxin O 1068 COG1226 Kef-type K+ transport systems, predicted NAD-binding component P 1069 COG1227 Inorganic pyrophosphatase/exopolyphosphatase C 1070 COG1228 Imidazolonepropionase and related amidohydrolases Q 1071 COG1229 Formylmethanofuran dehydrogenase subunit A C 1072 COG1230 Co/Zn/Cd efflux system component P 1073 COG1231 Monoamine oxidase E 1074 COG1232 Protoporphyrinogen oxidase H 1075 COG1233 Phytoene dehydrogenase and related proteins Q 1076 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III R 1077 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I R 1078 COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing J 1079 COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II R 1080 COG1238 Predicted membrane protein S 1081 COG1239 Mg-chelatase subunit ChlI H 1082 COG1240 Mg-chelatase subunit ChlD H 1083 COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family L 1084 COG1242 Predicted Fe-S oxidoreductase R 1085 COG1243 Histone acetyltransferase K,B 1086 COG1244 Predicted Fe-S oxidoreductase R 1087 COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog R 1088 COG1246 N-acetylglutamate synthase and related acetyltransferases E 1089 COG1247 Sortase and related acyltransferases M 1090 COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes C 1091 COG1250 3-hydroxyacyl-CoA dehydrogenase I 1092 COG1251 NAD(P)H-nitrite reductase C 1093 COG1252 NADH dehydrogenase, FAD-containing subunit C 1094 COG1253 Hemolysins and related proteins containing CBS domains R 1095 COG1254 Acylphosphatases C 1096 COG1255 Uncharacterized protein conserved in archaea S 1097 COG1256 Flagellar hook-associated protein N 1098 COG1257 Hydroxymethylglutaryl-CoA reductase I 1099 COG1258 Predicted pseudouridylate synthase J 1100 COG1259 Uncharacterized conserved protein S 1101 COG1260 Myo-inositol-1-phosphate synthase I 1102 COG1261 Flagellar basal body P-ring biosynthesis protein O,N 1103 COG1262 Uncharacterized conserved protein S 1104 COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific G 1105 COG1264 Phosphotransferase system IIB components G 1106 COG1266 Predicted metal-dependent membrane protease R 1107 COG1267 Phosphatidylglycerophosphatase A and related proteins I 1108 COG1268 Uncharacterized conserved protein R 1109 COG1269 Archaeal/vacuolar-type H+-ATPase subunit I C 1110 COG1270 Cobalamin biosynthesis protein CobD/CbiB H 1111 COG1271 Cytochrome bd-type quinol oxidase, subunit 1 C 1112 COG1272 Predicted membrane protein, hemolysin III homolog R 1113 COG1273 Uncharacterized conserved protein S 1114 COG1274 Phosphoenolpyruvate carboxykinase (GTP) C 1115 COG1275 Tellurite resistance protein and related permeases P 1116 COG1276 Putative copper export protein P 1117 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component R 1118 COG1278 Cold shock proteins K 1119 COG1279 Lysine efflux permease R 1120 COG1280 Putative threonine efflux protein E 1121 COG1281 Disulfide bond chaperones of the HSP33 family O 1122 COG1282 NAD/NADP transhydrogenase beta subunit C 1123 COG1283 Na+/phosphate symporter P 1124 COG1284 Uncharacterized conserved protein S 1125 COG1285 Uncharacterized membrane protein S 1126 COG1286 Uncharacterized membrane protein, required for colicin V production R 1127 COG1287 Uncharacterized membrane protein, required for N-linked glycosylation R 1128 COG1288 Predicted membrane protein S 1129 COG1289 Predicted membrane protein S 1130 COG1290 Cytochrome b subunit of the bc complex C 1131 COG1291 Flagellar motor component N 1132 COG1292 Choline-glycine betaine transporter M 1133 COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP K 1134 COG1294 Cytochrome bd-type quinol oxidase, subunit 2 C 1135 COG1295 Predicted membrane protein S 1136 COG1296 Predicted branched-chain amino acid permease (azaleucine resistance) E 1137 COG1297 Predicted membrane protein S 1138 COG1298 Flagellar biosynthesis pathway, component FlhA U,N 1139 COG1299 Phosphotransferase system, fructose-specific IIC component G 1140 COG1300 Uncharacterized membrane protein S 1141 COG1301 Na+/H+-dicarboxylate symporters C 1142 COG1302 Uncharacterized protein conserved in bacteria S 1143 COG1303 Uncharacterized protein conserved in archaea S 1144 COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases C 1145 COG1305 Transglutaminase-like enzymes, putative cysteine proteases E 1146 COG1306 Uncharacterized conserved protein S 1147 COG1307 Uncharacterized protein conserved in bacteria S 1148 COG1308 Transcription factor homologous to NACalpha-BTF3 K 1149 COG1309 Transcriptional regulator K 1150 COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily R 1151 COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B L 1152 COG1312 D-mannonate dehydratase G 1153 COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins R 1154 COG1314 Preprotein translocase subunit SecG U 1155 COG1315 Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain L 1156 COG1316 Transcriptional regulator K 1157 COG1317 Flagellar biosynthesis/type III secretory pathway protein U,N 1158 COG1318 Predicted transcriptional regulators K 1159 COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs C 1160 COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit P 1161 COG1321 Mn-dependent transcriptional regulator K 1162 COG1322 Uncharacterized protein conserved in bacteria S 1163 COG1323 Predicted nucleotidyltransferase R 1164 COG1324 Uncharacterized protein involved in tolerance to divalent cations P 1165 COG1325 Predicted exosome subunit J 1166 COG1326 Uncharacterized archaeal Zn-finger protein R 1167 COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains K 1168 COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase F 1169 COG1329 Transcriptional regulators, similar to M. xanthus CarD K 1170 COG1330 Exonuclease V gamma subunit L 1171 COG1331 Highly conserved protein containing a thioredoxin domain O 1172 COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1173 COG1333 ResB protein required for cytochrome c biosynthesis O 1174 COG1334 Uncharacterized flagellar protein FlaG N 1175 COG1335 Amidases related to nicotinamidase Q 1176 COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1177 COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1178 COG1338 Flagellar biosynthesis pathway, component FliP U,N 1179 COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon K,H 1180 COG1340 Uncharacterized archaeal coiled-coil protein S 1181 COG1341 Predicted GTPase or GTP-binding protein R 1182 COG1342 Predicted DNA-binding proteins R 1183 COG1343 Uncharacterized protein predicted to be involved in DNA repair L 1184 COG1344 Flagellin and related hook-associated proteins N 1185 COG1345 Flagellar capping protein N 1186 COG1346 Putative effector of murein hydrolase M 1187 COG1347 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD C 1188 COG1348 Nitrogenase subunit NifH (ATPase) P 1189 COG1349 Transcriptional regulators of sugar metabolism K,G 1190 COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) R 1191 COG1351 Predicted alternative thymidylate synthase F 1192 COG1352 Methylase of chemotaxis methyl-accepting proteins N,T 1193 COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs) R 1194 COG1354 Uncharacterized conserved protein S 1195 COG1355 Predicted dioxygenase R 1196 COG1356 Uncharacterized protein conserved in archaea S 1197 COG1357 Uncharacterized low-complexity proteins S 1198 COG1358 Ribosomal protein HS6-type (S12/L30/L7a) J 1199 COG1359 Uncharacterized conserved protein S 1200 COG1360 Flagellar motor protein N 1201 COG1361 S-layer domain M 1202 COG1362 Aspartyl aminopeptidase E 1203 COG1363 Cellulase M and related proteins G 1204 COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase) E 1205 COG1365 Predicted ATPase (PP-loop superfamily) R 1206 COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) T 1207 COG1367 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1208 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily M 1209 COG1369 RNase P/RNase MRP subunit POP5 J 1210 COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit O 1211 COG1371 Uncharacterized conserved protein S 1212 COG1372 Intein/homing endonuclease L 1213 COG1373 Predicted ATPase (AAA+ superfamily) R 1214 COG1374 Protein involved in ribosomal biogenesis, contains PUA domain J 1215 COG1376 Uncharacterized protein conserved in bacteria S 1216 COG1377 Flagellar biosynthesis pathway, component FlhB U,N 1217 COG1378 Predicted transcriptional regulators K 1218 COG1379 Uncharacterized conserved protein S 1219 COG1380 Putative effector of murein hydrolase LrgA R 1220 COG1381 Recombinational DNA repair protein (RecF pathway) L 1221 COG1382 Prefoldin, chaperonin cofactor O 1222 COG1383 Ribosomal protein S17E J 1223 COG1384 Lysyl-tRNA synthetase (class I) J 1224 COG1385 Uncharacterized protein conserved in bacteria S 1225 COG1386 Predicted transcriptional regulator containing the HTH domain K 1226 COG1387 Histidinol phosphatase and related hydrolases of the PHP family E,R 1227 COG1388 FOG: LysM repeat M 1228 COG1389 DNA topoisomerase VI, subunit B L 1229 COG1390 Archaeal/vacuolar-type H+-ATPase subunit E C 1230 COG1391 Glutamine synthetase adenylyltransferase O,T 1231 COG1392 Phosphate transport regulator (distant homolog of PhoU) P 1232 COG1393 Arsenate reductase and related proteins, glutaredoxin family P 1233 COG1394 Archaeal/vacuolar-type H+-ATPase subunit D C 1234 COG1395 Predicted transcriptional regulator K 1235 COG1396 Predicted transcriptional regulators K 1236 COG1397 ADP-ribosylglycohydrolase O 1237 COG1398 Fatty-acid desaturase I 1238 COG1399 Predicted metal-binding, possibly nucleic acid-binding protein R 1239 COG1400 Signal recognition particle 19 kDa protein U 1240 COG1401 GTPase subunit of restriction endonuclease V 1241 COG1402 Uncharacterized protein, putative amidase R 1242 COG1403 Restriction endonuclease V 1243 COG1404 Subtilisin-like serine proteases O 1244 COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB K 1245 COG1406 Predicted inhibitor of MCP methylation, homolog of CheC N 1246 COG1407 Predicted ICC-like phosphoesterases R 1247 COG1408 Predicted phosphohydrolases R 1248 COG1409 Predicted phosphohydrolases R 1249 COG1410 Methionine synthase I, cobalamin-binding domain E 1250 COG1411 Uncharacterized protein related to proFAR isomerase (HisA) R 1251 COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily R 1252 COG1413 FOG: HEAT repeat C 1253 COG1414 Transcriptional regulator K 1254 COG1415 Uncharacterized conserved protein S 1255 COG1416 Uncharacterized conserved protein S 1256 COG1417 Uncharacterized conserved protein S 1257 COG1418 Predicted HD superfamily hydrolase R 1258 COG1419 Flagellar GTP-binding protein N 1259 COG1420 Transcriptional regulator of heat shock gene K 1260 COG1421 Uncharacterized protein predicted to be involved in DNA repair L 1261 COG1422 Predicted membrane protein S 1262 COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III L 1263 COG1424 Pimeloyl-CoA synthetase H 1264 COG1426 Uncharacterized protein conserved in bacteria S 1265 COG1427 Predicted periplasmic solute-binding protein R 1266 COG1428 Deoxynucleoside kinases F 1267 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases H 1268 COG1430 Uncharacterized conserved protein S 1269 COG1431 Uncharacterized protein containing piwi/argonaute domain J 1270 COG1432 Uncharacterized conserved protein S 1271 COG1433 Uncharacterized conserved protein S 1272 COG1434 Uncharacterized conserved protein S 1273 COG1435 Thymidine kinase F 1274 COG1436 Archaeal/vacuolar-type H+-ATPase subunit F C 1275 COG1437 Adenylate cyclase, class 2 (thermophilic) F 1276 COG1438 Arginine repressor K 1277 COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module R 1278 COG1440 Phosphotransferase system cellobiose-specific component IIB G 1279 COG1441 O-succinylbenzoate synthase H 1280 COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases M 1281 COG1443 Isopentenyldiphosphate isomerase I 1282 COG1444 Predicted P-loop ATPase fused to an acetyltransferase R 1283 COG1445 Phosphotransferase system fructose-specific component IIB G 1284 COG1446 Asparaginase E 1285 COG1447 Phosphotransferase system cellobiose-specific component IIA G 1286 COG1448 Aspartate/tyrosine/aromatic aminotransferase E 1287 COG1449 Alpha-amylase/alpha-mannosidase G 1288 COG1450 Type II secretory pathway, component PulD U,N 1289 COG1451 Predicted metal-dependent hydrolase R 1290 COG1452 Organic solvent tolerance protein OstA M 1291 COG1453 Predicted oxidoreductases of the aldo/keto reductase family R 1292 COG1454 Alcohol dehydrogenase, class IV C 1293 COG1455 Phosphotransferase system cellobiose-specific component IIC G 1294 COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) C 1295 COG1457 Purine-cytosine permease and related proteins F 1296 COG1458 Predicted DNA-binding protein containing PIN domain R 1297 COG1459 Type II secretory pathway, component PulF U,N 1298 COG1460 Uncharacterized protein conserved in archaea S 1299 COG1461 Predicted kinase related to dihydroxyacetone kinase R 1300 COG1462 Uncharacterized protein involved in formation of curli polymers M 1301 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component Q 1302 COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen P 1303 COG1465 Predicted alternative 3-dehydroquinate synthase E 1304 COG1466 DNA polymerase III, delta subunit L 1305 COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit L 1306 COG1468 RecB family exonuclease L 1307 COG1469 Uncharacterized conserved protein S 1308 COG1470 Predicted membrane protein S 1309 COG1471 Ribosomal protein S4E J 1310 COG1472 Beta-glucosidase-related glycosidases G 1311 COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase R 1312 COG1474 Cdc6-related protein, AAA superfamily ATPase L,O 1313 COG1475 Predicted transcriptional regulators K 1314 COG1476 Predicted transcriptional regulators K 1315 COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis H 1316 COG1478 Uncharacterized conserved protein S 1317 COG1479 Uncharacterized conserved protein S 1318 COG1480 Predicted membrane-associated HD superfamily hydrolase R 1319 COG1481 Uncharacterized protein conserved in bacteria S 1320 COG1482 Phosphomannose isomerase G 1321 COG1483 Predicted ATPase (AAA+ superfamily) R 1322 COG1484 DNA replication protein L 1323 COG1485 Predicted ATPase R 1324 COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases G 1325 COG1487 Predicted nucleic acid-binding protein, contains PIN domain R 1326 COG1488 Nicotinic acid phosphoribosyltransferase H 1327 COG1489 DNA-binding protein, stimulates sugar fermentation R 1328 COG1490 D-Tyr-tRNAtyr deacylase J 1329 COG1491 Predicted RNA-binding protein J 1330 COG1492 Cobyric acid synthase H 1331 COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism T 1332 COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins G 1333 COG1495 Disulfide bond formation protein DsbB O 1334 COG1496 Uncharacterized conserved protein S 1335 COG1497 Predicted transcriptional regulator K 1336 COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog J 1337 COG1499 NMD protein affecting ribosome stability and mRNA decay J 1338 COG1500 Predicted exosome subunit J 1339 COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases G 1340 COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes I 1341 COG1503 Peptide chain release factor 1 (eRF1) J 1342 COG1504 Uncharacterized conserved protein S 1343 COG1505 Serine proteases of the peptidase family S9A E 1344 COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases E 1345 COG1507 Uncharacterized conserved protein S 1346 COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog K 1347 COG1509 Lysine 2,3-aminomutase E 1348 COG1510 Predicted transcriptional regulators K 1349 COG1511 Predicted membrane protein S 1350 COG1512 Beta-propeller domains of methanol dehydrogenase type R 1351 COG1513 Cyanate lyase P 1352 COG1514 2'-5' RNA ligase J 1353 COG1515 Deoxyinosine 3'endonuclease (endonuclease V) L 1354 COG1516 Flagellin-specific chaperone FliS U,O,N 1355 COG1517 Uncharacterized protein predicted to be involved in DNA repair L 1356 COG1518 Uncharacterized protein predicted to be involved in DNA repair L 1357 COG1519 3-deoxy-D-manno-octulosonic-acid transferase M 1358 COG1520 FOG: WD40-like repeat S 1359 COG1521 Putative transcriptional regulator, homolog of Bvg accessory factor K 1360 COG1522 Transcriptional regulators K 1361 COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases G 1362 COG1524 Uncharacterized proteins of the AP superfamily R 1363 COG1525 Micrococcal nuclease (thermonuclease) homologs L 1364 COG1526 Uncharacterized protein required for formate dehydrogenase activity C 1365 COG1527 Archaeal/vacuolar-type H+-ATPase subunit C C 1366 COG1528 Ferritin-like protein P 1367 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs C 1368 COG1530 Ribonucleases G and E J 1369 COG1531 Uncharacterized protein conserved in archaea S 1370 COG1532 Predicted RNA-binding protein R 1371 COG1533 DNA repair photolyase L 1372 COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein J 1373 COG1535 Isochorismate hydrolase Q 1374 COG1536 Flagellar motor switch protein N 1375 COG1537 Predicted RNA-binding proteins R 1376 COG1538 Outer membrane protein U,M 1377 COG1539 Dihydroneopterin aldolase H 1378 COG1540 Uncharacterized proteins, homologs of lactam utilization protein B R 1379 COG1541 Coenzyme F390 synthetase H 1380 COG1542 Uncharacterized conserved protein S 1381 COG1543 Uncharacterized conserved protein S 1382 COG1544 Ribosome-associated protein Y (PSrp-1) J 1383 COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon R 1384 COG1546 Uncharacterized protein (competence- and mitomycin-induced) R 1385 COG1547 Uncharacterized conserved protein S 1386 COG1548 Predicted transcriptional regulator/sugar kinase K,G 1387 COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain J 1388 COG1550 Uncharacterized protein conserved in bacteria S 1389 COG1551 Carbon storage regulator (could also regulate swarming and quorum sensing) T 1390 COG1552 Ribosomal protein L40E J 1391 COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction P 1392 COG1554 Trehalose and maltose hydrolases (possible phosphorylases) G 1393 COG1555 DNA uptake protein and related DNA-binding proteins L 1394 COG1556 Uncharacterized conserved protein S 1395 COG1558 Flagellar basal body rod protein N 1396 COG1559 Predicted periplasmic solute-binding protein R 1397 COG1560 Lauroyl/myristoyl acyltransferase M 1398 COG1561 Uncharacterized stress-induced protein S 1399 COG1562 Phytoene/squalene synthetase I 1400 COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter P 1401 COG1564 Thiamine pyrophosphokinase H 1402 COG1565 Uncharacterized conserved protein S 1403 COG1566 Multidrug resistance efflux pump V 1404 COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1405 COG1568 Predicted methyltransferases R 1406 COG1569 Predicted nucleic acid-binding protein, contains PIN domain R 1407 COG1570 Exonuclease VII, large subunit L 1408 COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain R 1409 COG1572 Uncharacterized conserved protein S 1410 COG1573 Uracil-DNA glycosylase L 1411 COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold R 1412 COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase H 1413 COG1576 Uncharacterized conserved protein S 1414 COG1577 Mevalonate kinase I 1415 COG1578 Uncharacterized conserved protein S 1416 COG1579 Zn-ribbon protein, possibly nucleic acid-binding R 1417 COG1580 Flagellar basal body-associated protein N 1418 COG1581 Archaeal DNA-binding protein K 1419 COG1582 Uncharacterized protein, possibly involved in motility N 1420 COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1421 COG1584 Predicted membrane protein S 1422 COG1585 Membrane protein implicated in regulation of membrane protease activity U,O 1423 COG1586 S-adenosylmethionine decarboxylase E 1424 COG1587 Uroporphyrinogen-III synthase H 1425 COG1588 RNase P/RNase MRP subunit p29 J 1426 COG1589 Cell division septal protein M 1427 COG1590 Uncharacterized conserved protein S 1428 COG1591 Holliday junction resolvase - archaeal type L 1429 COG1592 Rubrerythrin C 1430 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component G 1431 COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS K 1432 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog K 1433 COG1596 Periplasmic protein involved in polysaccharide export M 1434 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase I,R 1435 COG1598 Uncharacterized conserved protein S 1436 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins L 1437 COG1600 Uncharacterized Fe-S protein C 1438 COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain J 1439 COG1602 Uncharacterized conserved protein S 1440 COG1603 RNase P/RNase MRP subunit p30 J 1441 COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1442 COG1605 Chorismate mutase E 1443 COG1606 ATP-utilizing enzymes of the PP-loop superfamily R 1444 COG1607 Acyl-CoA hydrolase I 1445 COG1608 Predicted archaeal kinase R 1446 COG1609 Transcriptional regulators K 1447 COG1610 Uncharacterized conserved protein S 1448 COG1611 Predicted Rossmann fold nucleotide-binding protein R 1449 COG1612 Uncharacterized protein required for cytochrome oxidase assembly O 1450 COG1613 ABC-type sulfate transport system, periplasmic component P 1451 COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit C 1452 COG1615 Uncharacterized conserved protein S 1453 COG1617 Uncharacterized conserved protein S 1454 COG1618 Predicted nucleotide kinase F 1455 COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF V 1456 COG1620 L-lactate permease C 1457 COG1621 Beta-fructosidases (levanase/invertase) G 1458 COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 C 1459 COG1623 Predicted nucleic-acid-binding protein (contains the HHH domain) R 1460 COG1624 Uncharacterized conserved protein S 1461 COG1625 Fe-S oxidoreductase, related to NifB/MoaA family C 1462 COG1626 Neutral trehalase G 1463 COG1627 Uncharacterized protein conserved in archaea S 1464 COG1628 Uncharacterized conserved protein S 1465 COG1629 Outer membrane receptor proteins, mostly Fe transport P 1466 COG1630 Uncharacterized protein conserved in archaea S 1467 COG1631 Ribosomal protein L44E J 1468 COG1632 Ribosomal protein L15E J 1469 COG1633 Uncharacterized conserved protein S 1470 COG1634 Uncharacterized Rossmann fold enzyme R 1471 COG1635 Flavoprotein involved in thiazole biosynthesis H 1472 COG1636 Uncharacterized protein conserved in bacteria S 1473 COG1637 Predicted nuclease of the RecB family L 1474 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component G 1475 COG1639 Predicted signal transduction protein T 1476 COG1640 4-alpha-glucanotransferase G 1477 COG1641 Uncharacterized conserved protein S 1478 COG1643 HrpA-like helicases L 1479 COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10) K 1480 COG1645 Uncharacterized Zn-finger containing protein R 1481 COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold R 1482 COG1647 Esterase/lipase R 1483 COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) H 1484 COG1649 Uncharacterized protein conserved in bacteria S 1485 COG1650 Uncharacterized protein conserved in archaea S 1486 COG1651 Protein-disulfide isomerase O 1487 COG1652 Uncharacterized protein containing LysM domain S 1488 COG1653 ABC-type sugar transport system, periplasmic component G 1489 COG1654 Biotin operon repressor K 1490 COG1655 Uncharacterized protein conserved in bacteria S 1491 COG1656 Uncharacterized conserved protein S 1492 COG1657 Squalene cyclase I 1493 COG1658 Small primase-like proteins (Toprim domain) L 1494 COG1659 Uncharacterized protein, linocin/CFP29 homolog S 1495 COG1660 Predicted P-loop-containing kinase R 1496 COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif R 1497 COG1662 Transposase and inactivated derivatives, IS1 family L 1498 COG1663 Tetraacyldisaccharide-1-P 4'-kinase M 1499 COG1664 Integral membrane protein CcmA involved in cell shape determination M 1500 COG1665 Uncharacterized protein conserved in archaea S 1501 COG1666 Uncharacterized protein conserved in bacteria S 1502 COG1667 Uncharacterized protein conserved in archaea S 1503 COG1668 ABC-type Na+ efflux pump, permease component P,C 1504 COG1669 Predicted nucleotidyltransferases R 1505 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins J 1506 COG1671 Uncharacterized protein conserved in bacteria S 1507 COG1672 Predicted ATPase (AAA+ superfamily) R 1508 COG1673 Uncharacterized protein conserved in archaea S 1509 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins D 1510 COG1675 Transcription initiation factor IIE, alpha subunit K 1511 COG1676 tRNA splicing endonuclease J 1512 COG1677 Flagellar hook-basal body protein U,N 1513 COG1678 Putative transcriptional regulator K 1514 COG1679 Uncharacterized conserved protein S 1515 COG1680 Beta-lactamase class C and other penicillin binding proteins V 1516 COG1681 Archaeal flagellins N 1517 COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component M,G 1518 COG1683 Uncharacterized conserved protein S 1519 COG1684 Flagellar biosynthesis pathway, component FliR U,N 1520 COG1685 Archaeal shikimate kinase E,H 1521 COG1686 D-alanyl-D-alanine carboxypeptidase M 1522 COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance) E 1523 COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1524 COG1689 Uncharacterized protein conserved in archaea S 1525 COG1690 Uncharacterized conserved protein S 1526 COG1691 NCAIR mutase (PurE)-related proteins R 1527 COG1692 Uncharacterized protein conserved in bacteria S 1528 COG1693 Uncharacterized protein conserved in archaea S 1529 COG1694 Predicted pyrophosphatase R 1530 COG1695 Predicted transcriptional regulators K 1531 COG1696 Predicted membrane protein involved in D-alanine export M 1532 COG1697 DNA topoisomerase VI, subunit A L 1533 COG1698 Uncharacterized protein conserved in archaea S 1534 COG1699 Uncharacterized protein conserved in bacteria S 1535 COG1700 Uncharacterized conserved protein S 1536 COG1701 Uncharacterized protein conserved in archaea S 1537 COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase T 1538 COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family E 1539 COG1704 Uncharacterized conserved protein S 1540 COG1705 Muramidase (flagellum-specific) U,N 1541 COG1706 Flagellar basal-body P-ring protein N 1542 COG1707 ACT domain-containing protein R 1543 COG1708 Predicted nucleotidyltransferases R 1544 COG1709 Predicted transcriptional regulator K 1545 COG1710 Uncharacterized protein conserved in archaea S 1546 COG1711 Uncharacterized protein conserved in archaea S 1547 COG1712 Predicted dinucleotide-utilizing enzyme R 1548 COG1713 Predicted HD superfamily hydrolase involved in NAD metabolism H 1549 COG1714 Predicted membrane protein/domain S 1550 COG1715 Restriction endonuclease V 1551 COG1716 FOG: FHA domain T 1552 COG1717 Ribosomal protein L32E J 1553 COG1718 Serine/threonine protein kinase involved in cell cycle control D,T 1554 COG1719 Predicted hydrocarbon binding protein (contains V4R domain) R 1555 COG1720 Uncharacterized conserved protein S 1556 COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) R 1557 COG1722 Exonuclease VII small subunit L 1558 COG1723 Uncharacterized conserved protein S 1559 COG1724 Predicted periplasmic or secreted lipoprotein N 1560 COG1725 Predicted transcriptional regulators K 1561 COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA C 1562 COG1727 Ribosomal protein L18E J 1563 COG1728 Uncharacterized protein conserved in bacteria S 1564 COG1729 Uncharacterized protein conserved in bacteria S 1565 COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding O 1566 COG1731 Archaeal riboflavin synthase H 1567 COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) M 1568 COG1733 Predicted transcriptional regulators K 1569 COG1734 DnaK suppressor protein T 1570 COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold R 1571 COG1736 Diphthamide synthase subunit DPH2 J 1572 COG1737 Transcriptional regulators K 1573 COG1738 Uncharacterized conserved protein S 1574 COG1739 Uncharacterized conserved protein S 1575 COG1740 Ni,Fe-hydrogenase I small subunit C 1576 COG1741 Pirin-related protein R 1577 COG1742 Uncharacterized conserved protein S 1578 COG1743 Adenine-specific DNA methylase containing a Zn-ribbon L 1579 COG1744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein R 1580 COG1745 Predicted metal-binding protein R 1581 COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme) J 1582 COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA S 1583 COG1748 Saccharopine dehydrogenase and related proteins E 1584 COG1749 Flagellar hook protein FlgE N 1585 COG1750 Archaeal serine proteases R 1586 COG1751 Uncharacterized conserved protein S 1587 COG1752 Predicted esterase of the alpha-beta hydrolase superfamily R 1588 COG1753 Uncharacterized conserved protein S 1589 COG1754 Uncharacterized C-terminal domain of topoisomerase IA R 1590 COG1755 Uncharacterized protein conserved in bacteria S 1591 COG1756 Uncharacterized conserved protein S 1592 COG1757 Na+/H+ antiporter C 1593 COG1758 DNA-directed RNA polymerase, subunit K/omega K 1594 COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) R 1595 COG1760 L-serine deaminase E 1596 COG1761 DNA-directed RNA polymerase, subunit L K 1597 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) T,G 1598 COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein H 1599 COG1764 Predicted redox protein, regulator of disulfide bond formation O 1600 COG1765 Predicted redox protein, regulator of disulfide bond formation O 1601 COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein U,N 1602 COG1767 Triphosphoribosyl-dephospho-CoA synthetase H 1603 COG1768 Predicted phosphohydrolase R 1604 COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) L 1605 COG1770 Protease II E 1606 COG1771 Uncharacterized protein conserved in archaea S 1607 COG1772 Uncharacterized protein conserved in archaea S 1608 COG1773 Rubredoxin C 1609 COG1774 Uncharacterized homolog of PSP1 S 1610 COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB E 1611 COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation N,T 1612 COG1777 Predicted transcriptional regulators K 1613 COG1778 Low specificity phosphatase (HAD superfamily) R 1614 COG1779 C4-type Zn-finger protein R 1615 COG1780 Protein involved in ribonucleotide reduction F 1616 COG1781 Aspartate carbamoyltransferase, regulatory subunit F 1617 COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain R 1618 COG1783 Phage terminase large subunit R 1619 COG1784 Predicted membrane protein S 1620 COG1785 Alkaline phosphatase P 1621 COG1786 Uncharacterized conserved protein S 1622 COG1787 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes V 1623 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit I 1624 COG1790 Uncharacterized protein conserved in archaea S 1625 COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain S 1626 COG1792 Cell shape-determining protein M 1627 COG1793 ATP-dependent DNA ligase L 1628 COG1794 Aspartate racemase M 1629 COG1795 Uncharacterized conserved protein S 1630 COG1796 DNA polymerase IV (family X) L 1631 COG1797 Cobyrinic acid a,c-diamide synthase H 1632 COG1798 Diphthamide biosynthesis methyltransferase J 1633 COG1799 Uncharacterized protein conserved in bacteria S 1634 COG1800 Predicted transglutaminase-like proteases R 1635 COG1801 Uncharacterized conserved protein S 1636 COG1802 Transcriptional regulators K 1637 COG1803 Methylglyoxal synthase G 1638 COG1804 Predicted acyl-CoA transferases/carnitine dehydratase C 1639 COG1805 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB C 1640 COG1806 Uncharacterized protein conserved in bacteria S 1641 COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family M 1642 COG1808 Predicted membrane protein S 1643 COG1809 Uncharacterized conserved protein S 1644 COG1810 Uncharacterized protein conserved in archaea S 1645 COG1811 Uncharacterized membrane protein, possible Na+ channel or pump R 1646 COG1812 Archaeal S-adenosylmethionine synthetase E 1647 COG1813 Predicted transcription factor, homolog of eukaryotic MBF1 K 1648 COG1814 Uncharacterized membrane protein S 1649 COG1815 Flagellar basal body protein N 1650 COG1816 Adenosine deaminase F 1651 COG1817 Uncharacterized protein conserved in archaea S 1652 COG1818 Predicted RNA-binding protein, contains THUMP domain R 1653 COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase G,C 1654 COG1820 N-acetylglucosamine-6-phosphate deacetylase G 1655 COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) R 1656 COG1822 Predicted archaeal membrane protein S 1657 COG1823 Predicted Na+/dicarboxylate symporter R 1658 COG1824 Permease, similar to cation transporters P 1659 COG1825 Ribosomal protein L25 (general stress protein Ctc) J 1660 COG1826 Sec-independent protein secretion pathway components U 1661 COG1827 Predicted small molecule binding protein (contains 3H domain) R 1662 COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component F 1663 COG1829 Predicted archaeal kinase (sugar kinase superfamily) R 1664 COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes G 1665 COG1831 Predicted metal-dependent hydrolase (urease superfamily) R 1666 COG1832 Predicted CoA-binding protein R 1667 COG1833 Uncharacterized conserved protein S 1668 COG1834 N-Dimethylarginine dimethylaminohydrolase E 1669 COG1835 Predicted acyltransferases I 1670 COG1836 Predicted membrane protein S 1671 COG1837 Predicted RNA-binding protein (contains KH domain) R 1672 COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain C 1673 COG1839 Uncharacterized conserved protein S 1674 COG1840 ABC-type Fe3+ transport system, periplasmic component P 1675 COG1841 Ribosomal protein L30/L7E J 1676 COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription K,T 1677 COG1843 Flagellar hook capping protein N 1678 COG1844 Uncharacterized protein conserved in archaea S 1679 COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 C 1680 COG1846 Transcriptional regulators K 1681 COG1847 Predicted RNA-binding protein R 1682 COG1848 Predicted nucleic acid-binding protein, contains PIN domain R 1683 COG1849 Uncharacterized protein conserved in archaea S 1684 COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit G 1685 COG1851 Uncharacterized conserved protein S 1686 COG1852 Uncharacterized conserved protein S 1687 COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family R 1688 COG1854 LuxS protein involved in autoinducer AI2 synthesis T 1689 COG1855 ATPase (PilT family) R 1690 COG1856 Uncharacterized homolog of biotin synthetase S 1691 COG1857 Uncharacterized protein predicted to be involved in DNA repair L 1692 COG1858 Cytochrome c peroxidase P 1693 COG1859 RNA:NAD 2'-phosphotransferase J 1694 COG1860 Uncharacterized protein conserved in archaea S 1695 COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog M 1696 COG1862 Preprotein translocase subunit YajC U 1697 COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit P 1698 COG1864 DNA/RNA endonuclease G, NUC1 F 1699 COG1865 Uncharacterized conserved protein S 1700 COG1866 Phosphoenolpyruvate carboxykinase (ATP) C 1701 COG1867 N2,N2-dimethylguanosine tRNA methyltransferase J 1702 COG1868 Flagellar motor switch protein N 1703 COG1869 ABC-type ribose transport system, auxiliary component G 1704 COG1871 Chemotaxis protein; stimulates methylation of MCP proteins N,T 1705 COG1872 Uncharacterized conserved protein S 1706 COG1873 Uncharacterized conserved protein S 1707 COG1874 Beta-galactosidase G 1708 COG1875 Predicted ATPase related to phosphate starvation-inducible protein PhoH T 1709 COG1876 D-alanyl-D-alanine carboxypeptidase M 1710 COG1877 Trehalose-6-phosphatase G 1711 COG1878 Predicted metal-dependent hydrolase R 1712 COG1879 ABC-type sugar transport system, periplasmic component G 1713 COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit C 1714 COG1881 Phospholipid-binding protein R 1715 COG1882 Pyruvate-formate lyase C 1716 COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit C 1717 COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit I 1718 COG1885 Uncharacterized protein conserved in archaea S 1719 COG1886 Flagellar motor switch/type III secretory pathway protein U,N 1720 COG1887 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC M 1721 COG1888 Uncharacterized protein conserved in archaea S 1722 COG1889 Fibrillarin-like rRNA methylase J 1723 COG1890 Ribosomal protein S3AE J 1724 COG1891 Uncharacterized protein conserved in archaea S 1725 COG1892 Uncharacterized protein conserved in archaea S 1726 COG1893 Ketopantoate reductase H 1727 COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit C 1728 COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN S 1729 COG1896 Predicted hydrolases of HD superfamily R 1730 COG1897 Homoserine trans-succinylase E 1731 COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes M 1732 COG1899 Deoxyhypusine synthase O 1733 COG1900 Uncharacterized conserved protein S 1734 COG1901 Uncharacterized conserved protein S 1735 COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family C 1736 COG1903 Cobalamin biosynthesis protein CbiD H 1737 COG1904 Glucuronate isomerase G 1738 COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit C 1739 COG1906 Uncharacterized conserved protein S 1740 COG1907 Predicted archaeal sugar kinases R 1741 COG1908 Coenzyme F420-reducing hydrogenase, delta subunit C 1742 COG1909 Uncharacterized protein conserved in archaea S 1743 COG1910 Periplasmic molybdate-binding protein/domain P 1744 COG1911 Ribosomal protein L30E J 1745 COG1912 Uncharacterized conserved protein S 1746 COG1913 Predicted Zn-dependent proteases R 1747 COG1914 Mn2+ and Fe2+ transporters of the NRAMP family P 1748 COG1915 Uncharacterized conserved protein S 1749 COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein) S 1750 COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain S 1751 COG1918 Fe2+ transport system protein A P 1752 COG1920 Uncharacterized conserved protein S 1753 COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase] E 1754 COG1922 Teichoic acid biosynthesis proteins M 1755 COG1923 Uncharacterized host factor I protein R 1756 COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) I 1757 COG1925 Phosphotransferase system, HPr-related proteins G 1758 COG1926 Predicted phosphoribosyltransferases R 1759 COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase C 1760 COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase O 1761 COG1929 Glycerate kinase G 1762 COG1930 ABC-type cobalt transport system, periplasmic component P 1763 COG1931 Uncharacterized protein conserved in archaea S 1764 COG1932 Phosphoserine aminotransferase E,H 1765 COG1933 Archaeal DNA polymerase II, large subunit L 1766 COG1934 Uncharacterized protein conserved in bacteria S 1767 COG1935 Uncharacterized conserved protein S 1768 COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases) F 1769 COG1937 Uncharacterized protein conserved in bacteria S 1770 COG1938 Archaeal enzymes of ATP-grasp superfamily R 1771 COG1939 Uncharacterized protein conserved in bacteria S 1772 COG1940 Transcriptional regulator/sugar kinase K,G 1773 COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit C 1774 COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog R 1775 COG1943 Transposase and inactivated derivatives L 1776 COG1944 Uncharacterized conserved protein S 1777 COG1945 Uncharacterized conserved protein S 1778 COG1946 Acyl-CoA thioesterase I 1779 COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase I 1780 COG1948 ERCC4-type nuclease L 1781 COG1949 Oligoribonuclease (3'->5' exoribonuclease) A 1782 COG1950 Predicted membrane protein S 1783 COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain C 1784 COG1952 Preprotein translocase subunit SecB U 1785 COG1953 Cytosine/uracil/thiamine/allantoin permeases F,H 1786 COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) K 1787 COG1955 Archaeal flagella assembly protein J U,N 1788 COG1956 GAF domain-containing protein T 1789 COG1957 Inosine-uridine nucleoside N-ribohydrolase F 1790 COG1958 Small nuclear ribonucleoprotein (snRNP) homolog K 1791 COG1959 Predicted transcriptional regulator K 1792 COG1960 Acyl-CoA dehydrogenases I 1793 COG1961 Site-specific recombinases, DNA invertase Pin homologs L 1794 COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H H 1795 COG1963 Uncharacterized protein conserved in bacteria S 1796 COG1964 Predicted Fe-S oxidoreductases R 1797 COG1965 Protein implicated in iron transport, frataxin homolog P 1798 COG1966 Carbon starvation protein, predicted membrane protein T 1799 COG1967 Predicted membrane protein S 1800 COG1968 Uncharacterized bacitracin resistance protein V 1801 COG1969 Ni,Fe-hydrogenase I cytochrome b subunit C 1802 COG1970 Large-conductance mechanosensitive channel M 1803 COG1971 Predicted membrane protein S 1804 COG1972 Nucleoside permease F 1805 COG1973 Hydrogenase maturation factor O 1806 COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) K,T 1807 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family O 1808 COG1976 Translation initiation factor 6 (eIF-6) J 1809 COG1977 Molybdopterin converting factor, small subunit H 1810 COG1978 Uncharacterized protein conserved in bacteria S 1811 COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family C 1812 COG1980 Archaeal fructose 1,6-bisphosphatase G 1813 COG1981 Predicted membrane protein S 1814 COG1982 Arginine/lysine/ornithine decarboxylases E 1815 COG1983 Putative stress-responsive transcriptional regulator K,T 1816 COG1984 Allophanate hydrolase subunit 2 E 1817 COG1985 Pyrimidine reductase, riboflavin biosynthesis H 1818 COG1986 Uncharacterized conserved protein S 1819 COG1987 Flagellar biosynthesis pathway, component FliQ U,N 1820 COG1988 Predicted membrane-bound metal-dependent hydrolases R 1821 COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases U,O,N 1822 COG1990 Uncharacterized conserved protein S 1823 COG1991 Uncharacterized conserved protein S 1824 COG1992 Uncharacterized conserved protein S 1825 COG1993 Uncharacterized conserved protein S 1826 COG1994 Zn-dependent proteases R 1827 COG1995 Pyridoxal phosphate biosynthesis protein H 1828 COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) K 1829 COG1997 Ribosomal protein L37AE/L43A J 1830 COG1998 Ribosomal protein S27AE J 1831 COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems R 1832 COG2000 Predicted Fe-S protein R 1833 COG2001 Uncharacterized protein conserved in bacteria S 1834 COG2002 Regulators of stationary/sporulation gene expression K 1835 COG2003 DNA repair proteins L 1836 COG2004 Ribosomal protein S24E J 1837 COG2005 N-terminal domain of molybdenum-binding protein R 1838 COG2006 Uncharacterized conserved protein S 1839 COG2007 Ribosomal protein S8E J 1840 COG2008 Threonine aldolase E 1841 COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit C 1842 COG2010 Cytochrome c, mono- and diheme variants C 1843 COG2011 ABC-type metal ion transport system, permease component P 1844 COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5 K 1845 COG2013 Uncharacterized conserved protein S 1846 COG2014 Uncharacterized conserved protein S 1847 COG2015 Alkyl sulfatase and related hydrolases Q 1848 COG2016 Predicted RNA-binding protein (contains PUA domain) J 1849 COG2017 Galactose mutarotase and related enzymes G 1850 COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid R 1851 COG2019 Archaeal adenylate kinase F 1852 COG2020 Putative protein-S-isoprenylcysteine methyltransferase O 1853 COG2021 Homoserine acetyltransferase E 1854 COG2022 Uncharacterized enzyme of thiazole biosynthesis H 1855 COG2023 RNase P subunit RPR2 J 1856 COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type) J 1857 COG2025 Electron transfer flavoprotein, alpha subunit C 1858 COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system J,D 1859 COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) M 1860 COG2028 Uncharacterized conserved protein S 1861 COG2029 Uncharacterized conserved protein S 1862 COG2030 Acyl dehydratase I 1863 COG2031 Short chain fatty acids transporter I 1864 COG2032 Cu/Zn superoxide dismutase P 1865 COG2033 Desulfoferrodoxin C 1866 COG2034 Predicted membrane protein S 1867 COG2035 Predicted membrane protein S 1868 COG2036 Histones H3 and H4 B 1869 COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase C 1870 COG2038 NaMN:DMB phosphoribosyltransferase H 1871 COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) O 1872 COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) E 1873 COG2041 Sulfite oxidase and related enzymes R 1874 COG2042 Uncharacterized conserved protein S 1875 COG2043 Uncharacterized protein conserved in archaea S 1876 COG2044 Predicted peroxiredoxins R 1877 COG2045 Phosphosulfolactate phosphohydrolase and related enzymes H,R 1878 COG2046 ATP sulfurylase (sulfate adenylyltransferase) P 1879 COG2047 Uncharacterized protein (ATP-grasp superfamily) R 1880 COG2048 Heterodisulfide reductase, subunit B C 1881 COG2049 Allophanate hydrolase subunit 1 E 1882 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism Q 1883 COG2051 Ribosomal protein S27E J 1884 COG2052 Uncharacterized protein conserved in bacteria S 1885 COG2053 Ribosomal protein S28E/S33 J 1886 COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases R 1887 COG2055 Malate/L-lactate dehydrogenases C 1888 COG2056 Predicted permease R 1889 COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit I 1890 COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2 J 1891 COG2059 Chromate transport protein ChrA P 1892 COG2060 K+-transporting ATPase, A chain P 1893 COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase E 1894 COG2062 Phosphohistidine phosphatase SixA T 1895 COG2063 Flagellar basal body L-ring protein N 1896 COG2064 Flp pilus assembly protein TadC U,N 1897 COG2065 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase F 1898 COG2066 Glutaminase E 1899 COG2067 Long-chain fatty acid transport protein I 1900 COG2068 Uncharacterized MobA-related protein R 1901 COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein) C 1902 COG2070 Dioxygenases related to 2-nitropropane dioxygenase R 1903 COG2071 Predicted glutamine amidotransferases R 1904 COG2072 Predicted flavoprotein involved in K+ transport P 1905 COG2073 Cobalamin biosynthesis protein CbiG H 1906 COG2074 2-phosphoglycerate kinase G 1907 COG2075 Ribosomal protein L24E J 1908 COG2076 Membrane transporters of cations and cationic drugs P 1909 COG2077 Peroxiredoxin O 1910 COG2078 Uncharacterized conserved protein S 1911 COG2079 Uncharacterized protein involved in propionate catabolism R 1912 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs C 1913 COG2081 Predicted flavoproteins R 1914 COG2082 Precorrin isomerase H 1915 COG2083 Uncharacterized protein conserved in archaea S 1916 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases I 1917 COG2085 Predicted dinucleotide-binding enzymes R 1918 COG2086 Electron transfer flavoprotein, beta subunit C 1919 COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase H 1920 COG2088 Uncharacterized protein, involved in the regulation of septum location M 1921 COG2089 Sialic acid synthase M 1922 COG2090 Uncharacterized protein conserved in archaea S 1923 COG2091 Phosphopantetheinyl transferase H 1924 COG2092 Translation elongation factor EF-1beta J 1925 COG2093 DNA-directed RNA polymerase, subunit E'' K 1926 COG2094 3-methyladenine DNA glycosylase L 1927 COG2095 Multiple antibiotic transporter U 1928 COG2096 Uncharacterized conserved protein S 1929 COG2097 Ribosomal protein L31E J 1930 COG2098 Uncharacterized protein conserved in archaea S 1931 COG2099 Precorrin-6x reductase H 1932 COG2100 Predicted Fe-S oxidoreductase R 1933 COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB K 1934 COG2102 Predicted ATPases of PP-loop superfamily R 1935 COG2103 Predicted sugar phosphate isomerase R 1936 COG2104 Sulfur transfer protein involved in thiamine biosynthesis H 1937 COG2105 Uncharacterized conserved protein S 1938 COG2106 Uncharacterized conserved protein S 1939 COG2107 Predicted periplasmic solute-binding protein R 1940 COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme R 1941 COG2109 ATP:corrinoid adenosyltransferase H 1942 COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 R 1943 COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit P 1944 COG2112 Predicted Ser/Thr protein kinase T 1945 COG2113 ABC-type proline/glycine betaine transport systems, periplasmic components E 1946 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) T 1947 COG2115 Xylose isomerase G 1948 COG2116 Formate/nitrite family of transporters P 1949 COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain J 1950 COG2118 DNA-binding protein R 1951 COG2119 Predicted membrane protein S 1952 COG2120 Uncharacterized proteins, LmbE homologs S 1953 COG2121 Uncharacterized protein conserved in bacteria S 1954 COG2122 Uncharacterized conserved protein S 1955 COG2123 RNase PH-related exoribonuclease J 1956 COG2124 Cytochrome P450 Q 1957 COG2125 Ribosomal protein S6E (S10) J 1958 COG2126 Ribosomal protein L37E J 1959 COG2127 Uncharacterized conserved protein S 1960 COG2128 Uncharacterized conserved protein S 1961 COG2129 Predicted phosphoesterases, related to the Icc protein R 1962 COG2130 Putative NADP-dependent oxidoreductases R 1963 COG2131 Deoxycytidylate deaminase F 1964 COG2132 Putative multicopper oxidases Q 1965 COG2133 Glucose/sorbosone dehydrogenases G 1966 COG2134 CDP-diacylglycerol pyrophosphatase I 1967 COG2135 Uncharacterized conserved protein S 1968 COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain J,A 1969 COG2137 Uncharacterized protein conserved in bacteria R 1970 COG2138 Uncharacterized conserved protein S 1971 COG2139 Ribosomal protein L21E J 1972 COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes G,R 1973 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases C 1974 COG2142 Succinate dehydrogenase, hydrophobic anchor subunit C 1975 COG2143 Thioredoxin-related protein O 1976 COG2144 Selenophosphate synthetase-related proteins R 1977 COG2145 Hydroxyethylthiazole kinase, sugar kinase family H 1978 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases P,R 1979 COG2147 Ribosomal protein L19E J 1980 COG2148 Sugar transferases involved in lipopolysaccharide synthesis M 1981 COG2149 Predicted membrane protein S 1982 COG2150 Predicted regulator of amino acid metabolism, contains ACT domain R 1983 COG2151 Predicted metal-sulfur cluster biosynthetic enzyme R 1984 COG2152 Predicted glycosylase G 1985 COG2153 Predicted acyltransferase R 1986 COG2154 Pterin-4a-carbinolamine dehydratase H 1987 COG2155 Uncharacterized conserved protein S 1988 COG2156 K+-transporting ATPase, c chain P 1989 COG2157 Ribosomal protein L20A (L18A) J 1990 COG2158 Uncharacterized protein containing a Zn-finger-like domain R 1991 COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold R 1992 COG2160 L-arabinose isomerase G 1993 COG2161 Antitoxin of toxin-antitoxin stability system D 1994 COG2162 Arylamine N-acetyltransferase Q 1995 COG2163 Ribosomal protein L14E/L6E/L27E J 1996 COG2164 Uncharacterized conserved protein S 1997 COG2165 Type II secretory pathway, pseudopilin PulG U,N 1998 COG2166 SufE protein probably involved in Fe-S center assembly R 1999 COG2167 Ribosomal protein L39E J 2000 COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur P 2001 COG2169 Adenosine deaminase F 2002 COG2170 Uncharacterized conserved protein S 2003 COG2171 Tetrahydrodipicolinate N-succinyltransferase E 2004 COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase) T 2005 COG2173 D-alanyl-D-alanine dipeptidase M 2006 COG2174 Ribosomal protein L34E J 2007 COG2175 Probable taurine catabolism dioxygenase Q 2008 COG2176 DNA polymerase III, alpha subunit (gram-positive type) L 2009 COG2177 Cell division protein D 2010 COG2178 Predicted RNA-binding protein of the translin family J 2011 COG2179 Predicted hydrolase of the HAD superfamily R 2012 COG2180 Nitrate reductase delta subunit C 2013 COG2181 Nitrate reductase gamma subunit C 2014 COG2182 Maltose-binding periplasmic proteins/domains G 2015 COG2183 Transcriptional accessory protein K 2016 COG2184 Protein involved in cell division D 2017 COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) I 2018 COG2186 Transcriptional regulators K 2019 COG2187 Uncharacterized protein conserved in bacteria S 2020 COG2188 Transcriptional regulators K 2021 COG2189 Adenine specific DNA methylase Mod L 2022 COG2190 Phosphotransferase system IIA components G 2023 COG2191 Formylmethanofuran dehydrogenase subunit E C 2024 COG2192 Predicted carbamoyl transferase, NodU family O 2025 COG2193 Bacterioferritin (cytochrome b1) P 2026 COG2194 Predicted membrane-associated, metal-dependent hydrolase R 2027 COG2195 Di- and tripeptidases E 2028 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K,T 2029 COG2198 FOG: HPt domain T 2030 COG2199 FOG: GGDEF domain T 2031 COG2200 FOG: EAL domain T 2032 COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain N,T 2033 COG2202 FOG: PAS/PAC domain T 2034 COG2203 FOG: GAF domain T 2035 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains T 2036 COG2205 Osmosensitive K+ channel histidine kinase T 2037 COG2206 HD-GYP domain T 2038 COG2207 AraC-type DNA-binding domain-containing proteins K 2039 COG2208 Serine phosphatase RsbU, regulator of sigma subunit K,T 2040 COG2209 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE C 2041 COG2210 Uncharacterized conserved protein S 2042 COG2211 Na+/melibiose symporter and related transporters G 2043 COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit P 2044 COG2213 Phosphotransferase system, mannitol-specific IIBC component G 2045 COG2214 DnaJ-class molecular chaperone O 2046 COG2215 ABC-type uncharacterized transport system, permease component R 2047 COG2216 High-affinity K+ transport system, ATPase chain B P 2048 COG2217 Cation transport ATPase P 2049 COG2218 Formylmethanofuran dehydrogenase subunit C C 2050 COG2219 Eukaryotic-type DNA primase, large subunit L 2051 COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold R 2052 COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits C 2053 COG2222 Predicted phosphosugar isomerases M 2054 COG2223 Nitrate/nitrite transporter P 2055 COG2224 Isocitrate lyase C 2056 COG2225 Malate synthase C 2057 COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis H 2058 COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase H 2059 COG2229 Predicted GTPase R 2060 COG2230 Cyclopropane fatty acid synthase and related methyltransferases M 2061 COG2231 Uncharacterized protein related to Endonuclease III L 2062 COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase R 2063 COG2233 Xanthine/uracil permeases F 2064 COG2234 Predicted aminopeptidases R 2065 COG2235 Arginine deiminase E 2066 COG2236 Predicted phosphoribosyltransferases R 2067 COG2237 Predicted membrane protein S 2068 COG2238 Ribosomal protein S19E (S16A) J 2069 COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) P 2070 COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase H 2071 COG2241 Precorrin-6B methylase 1 H 2072 COG2242 Precorrin-6B methylase 2 H 2073 COG2243 Precorrin-2 methylase H 2074 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid R 2075 COG2245 Predicted membrane protein S 2076 COG2246 Predicted membrane protein S 2077 COG2247 Putative cell wall-binding domain M 2078 COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily) R 2079 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) R 2080 COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN S 2081 COG2251 Predicted nuclease (RecB family) R 2082 COG2252 Permeases R 2083 COG2253 Uncharacterized conserved protein S 2084 COG2254 Predicted HD superfamily hydrolase, possibly a nuclease L 2085 COG2255 Holliday junction resolvasome, helicase subunit L 2086 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase L 2087 COG2257 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB S 2088 COG2258 Uncharacterized protein conserved in bacteria S 2089 COG2259 Predicted membrane protein S 2090 COG2260 Predicted Zn-ribbon RNA-binding protein J 2091 COG2261 Predicted membrane protein S 2092 COG2262 GTPases R 2093 COG2263 Predicted RNA methylase J 2094 COG2264 Ribosomal protein L11 methylase J 2095 COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase J 2096 COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase H 2097 COG2267 Lysophospholipase I 2098 COG2268 Uncharacterized protein conserved in bacteria S 2099 COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) J 2100 COG2270 Permeases of the major facilitator superfamily R 2101 COG2271 Sugar phosphate permease G 2102 COG2272 Carboxylesterase type B I 2103 COG2273 Beta-glucanase/Beta-glucan synthetase G 2104 COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain V 2105 COG2301 Citrate lyase beta subunit G 2106 COG2302 Uncharacterized conserved protein, contains S4-like domain S 2107 COG2303 Choline dehydrogenase and related flavoproteins E 2108 COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain R 2109 COG2306 Uncharacterized conserved protein S 2110 COG2307 Uncharacterized protein conserved in bacteria S 2111 COG2308 Uncharacterized conserved protein S 2112 COG2309 Leucyl aminopeptidase (aminopeptidase T) E 2113 COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 T 2114 COG2311 Predicted membrane protein S 2115 COG2312 Erythromycin esterase homolog R 2116 COG2313 Uncharacterized enzyme involved in pigment biosynthesis Q 2117 COG2314 Predicted membrane protein S 2118 COG2315 Uncharacterized protein conserved in bacteria S 2119 COG2316 Predicted hydrolase (HD superfamily) R 2120 COG2317 Zn-dependent carboxypeptidase E 2121 COG2318 Uncharacterized protein conserved in bacteria S 2122 COG2319 FOG: WD40 repeat R 2123 COG2320 Uncharacterized conserved protein S 2124 COG2321 Predicted metalloprotease R 2125 COG2322 Predicted membrane protein S 2126 COG2323 Predicted membrane protein S 2127 COG2324 Predicted membrane protein S 2128 COG2326 Uncharacterized conserved protein S 2129 COG2327 Uncharacterized conserved protein S 2130 COG2329 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides R 2131 COG2331 Uncharacterized protein conserved in bacteria S 2132 COG2332 Cytochrome c-type biogenesis protein CcmE O 2133 COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily) R 2134 COG2334 Putative homoserine kinase type II (protein kinase fold) R 2135 COG2335 Secreted and surface protein containing fasciclin-like repeats M 2136 COG2336 Growth regulator T 2137 COG2337 Growth inhibitor T 2138 COG2339 Predicted membrane protein S 2139 COG2340 Uncharacterized protein with SCP/PR1 domains S 2140 COG2342 Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase G 2141 COG2343 Uncharacterized protein conserved in bacteria S 2142 COG2344 AT-rich DNA-binding protein R 2143 COG2345 Predicted transcriptional regulator K 2144 COG2346 Truncated hemoglobins R 2145 COG2348 Uncharacterized protein involved in methicillin resistance V 2146 COG2350 Uncharacterized protein conserved in bacteria S 2147 COG2351 Transthyretin-like protein R 2148 COG2352 Phosphoenolpyruvate carboxylase C 2149 COG2353 Uncharacterized conserved protein S 2150 COG2354 Uncharacterized protein conserved in bacteria S 2151 COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog E 2152 COG2356 Endonuclease I L 2153 COG2357 Uncharacterized protein conserved in bacteria S 2154 COG2358 TRAP-type uncharacterized transport system, periplasmic component R 2155 COG2359 Uncharacterized protein conserved in bacteria S 2156 COG2360 Leu/Phe-tRNA-protein transferase O 2157 COG2361 Uncharacterized conserved protein S 2158 COG2362 D-aminopeptidase E 2159 COG2363 Uncharacterized small membrane protein S 2160 COG2364 Predicted membrane protein S 2161 COG2365 Protein tyrosine/serine phosphatase T 2162 COG2366 Protein related to penicillin acylase R 2163 COG2367 Beta-lactamase class A V 2164 COG2368 Aromatic ring hydroxylase Q 2165 COG2369 Uncharacterized protein, homolog of phage Mu protein gp30 S 2166 COG2370 Hydrogenase/urease accessory protein O 2167 COG2371 Urease accessory protein UreE O 2168 COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC R 2169 COG2373 Large extracellular alpha-helical protein R 2170 COG2374 Predicted extracellular nuclease R 2171 COG2375 Siderophore-interacting protein P 2172 COG2376 Dihydroxyacetone kinase G 2173 COG2377 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases O 2174 COG2378 Predicted transcriptional regulator K 2175 COG2379 Putative glycerate kinase G 2176 COG2380 Uncharacterized protein conserved in bacteria S 2177 COG2382 Enterochelin esterase and related enzymes P 2178 COG2383 Uncharacterized conserved protein S 2179 COG2384 Predicted SAM-dependent methyltransferase R 2180 COG2385 Sporulation protein and related proteins D 2181 COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component O 2182 COG2388 Predicted acetyltransferase R 2183 COG2389 Uncharacterized metal-binding protein R 2184 COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain K 2185 COG2391 Predicted transporter component R 2186 COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain R 2187 COG2402 Predicted nucleic acid-binding protein, contains PIN domain R 2188 COG2403 Predicted GTPase R 2189 COG2404 Predicted phosphohydrolase (DHH superfamily) R 2190 COG2405 Predicted nucleic acid-binding protein, contains PIN domain R 2191 COG2406 Protein distantly related to bacterial ferritins R 2192 COG2407 L-fucose isomerase and related proteins G 2193 COG2409 Predicted drug exporters of the RND superfamily R 2194 COG2410 Uncharacterized conserved protein S 2195 COG2411 Uncharacterized conserved protein S 2196 COG2412 Uncharacterized conserved protein S 2197 COG2413 Predicted nucleotidyltransferase R 2198 COG2414 Aldehyde:ferredoxin oxidoreductase C 2199 COG2419 Uncharacterized conserved protein S 2200 COG2421 Predicted acetamidase/formamidase C 2201 COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog E 2202 COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain R 2203 COG2426 Predicted membrane protein S 2204 COG2427 Uncharacterized conserved protein S 2205 COG2428 Uncharacterized conserved protein S 2206 COG2429 Uncharacterized conserved protein S 2207 COG2430 Uncharacterized conserved protein S 2208 COG2431 Predicted membrane protein S 2209 COG2433 Uncharacterized conserved protein S 2210 COG2440 Ferredoxin-like protein C 2211 COG2441 Predicted butyrate kinase C 2212 COG2442 Uncharacterized conserved protein S 2213 COG2443 Preprotein translocase subunit Sss1 U 2214 COG2445 Uncharacterized conserved protein S 2215 COG2450 Uncharacterized conserved protein S 2216 COG2451 Ribosomal protein L35AE/L33A J 2217 COG2452 Predicted site-specific integrase-resolvase L 2218 COG2453 Predicted protein-tyrosine phosphatase T 2219 COG2454 Uncharacterized conserved protein S 2220 COG2456 Uncharacterized conserved protein S 2221 COG2457 Uncharacterized conserved protein S 2222 COG2461 Uncharacterized conserved protein S 2223 COG2469 Uncharacterized conserved protein S 2224 COG2501 Uncharacterized conserved protein S 2225 COG2502 Asparagine synthetase A E 2226 COG2503 Predicted secreted acid phosphatase R 2227 COG2508 Regulator of polyketide synthase expression T,Q 2228 COG2509 Uncharacterized FAD-dependent dehydrogenases R 2229 COG2510 Predicted membrane protein S 2230 COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) J 2231 COG2512 Uncharacterized membrane-associated protein/domain S 2232 COG2513 PEP phosphonomutase and related enzymes G 2233 COG2514 Predicted ring-cleavage extradiol dioxygenase R 2234 COG2515 1-aminocyclopropane-1-carboxylate deaminase E 2235 COG2516 Biotin synthase-related enzyme R 2236 COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain R 2237 COG2518 Protein-L-isoaspartate carboxylmethyltransferase O 2238 COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases J 2239 COG2520 Predicted methyltransferase R 2240 COG2521 Predicted archaeal methyltransferase R 2241 COG2522 Predicted transcriptional regulator R 2242 COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains K 2243 COG2602 Beta-lactamase class D V 2244 COG2603 Predicted ATPase R 2245 COG2604 Uncharacterized protein conserved in bacteria S 2246 COG2605 Predicted kinase related to galactokinase and mevalonate kinase R 2247 COG2606 Uncharacterized conserved protein S 2248 COG2607 Predicted ATPase (AAA+ superfamily) R 2249 COG2608 Copper chaperone P 2250 COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component C 2251 COG2610 H+/gluconate symporter and related permeases G,E 2252 COG2703 Hemerythrin P 2253 COG2704 Anaerobic C4-dicarboxylate transporter R 2254 COG2706 3-carboxymuconate cyclase G 2255 COG2707 Predicted membrane protein S 2256 COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains C 2257 COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis. R 2258 COG2716 Glycine cleavage system regulatory protein E 2259 COG2717 Predicted membrane protein S 2260 COG2718 Uncharacterized conserved protein S 2261 COG2719 Uncharacterized conserved protein S 2262 COG2720 Uncharacterized vancomycin resistance protein V 2263 COG2721 Altronate dehydratase G 2264 COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase G 2265 COG2730 Endoglucanase G 2266 COG2731 Beta-galactosidase, beta subunit G 2267 COG2732 Barstar, RNAse (barnase) inhibitor K 2268 COG2733 Predicted membrane protein S 2269 COG2738 Predicted Zn-dependent proteas