IGP Core
Macromolecular NMR
CORE MANAGER: Robert Peterson
Phone: (310) 825-1816
Email: peterson@mbi.ucla.edu
1435 Molecular Sciences Building, 609 Young Dr.
Professor Robert Clubb (310) 206-2334
Professor Juli Feigon (310) 206-6922
IGP Core
Phone: (310) 825-1816
Email: peterson@mbi.ucla.edu
1435 Molecular Sciences Building, 609 Young Dr.
Professor Robert Clubb (310) 206-2334
Professor Juli Feigon (310) 206-6922
The NMR Core provides advanced nuclear magnetic resonance (NMR) spectrometers and related equipment for the study of macromolecular structure and dynamics in solution by experienced users. In this capacity the core facility primarily provides the research tools in which to perform detailed measurements on complex biological systems.
The facility provides non-expert members of the DOE laboratory with access to NMR spectroscopy for more routine applications. These applications include: screening wild-type and mutated protein samples to determine their structural integrity, making small molecule binding affinity measurements, and temperature and denaturant studies of protein stability.
The UCLA-DOE NMR Core Facility has two primary modes of operation. At present, almost all of the instrument time is shared between the Clubb and Feigon laboratories which use more advanced NMR spectroscopic techniques in their research programs. In the second mode of operation the facility serves the needs of members of the DOE laboratory and the university community by performing more basic NMR experiments and by providing training and supervision of inexperienced users.
Instrumentation in the facility is maintained by the facility manager and members of the two primary research teams. The manager either supervises or actively participates in cryogen fills, software and hardware upgrades, general system maintenance and trouble-shoots any problems that arise. The facility manager also provides assistance and training to all spectrometer users to help them successfully complete their research projects.