LOCAL

Amyloid Journal Club

Introduction

This meeting is devoted to integration and acceleration of research projects of amyloids in the Molecular Biology Institute. A very short proposal for this organization can be found Day: The second Wednesday of every month at 4:00pm
Place: MBI 244 (2nd floor conference room)

Date & Time Speaker Topic (Journals)
December, 2008 Majumdar Devdoot  
November, 2008 Rebecca Nelson  
October, 2008 Zhefeng Guo  
September, 2008 Heather McFarlane  
August, 2008 Marcin Apostol  
July, 2008 Wiltzius Jed  
June, 2008 Wiltzius Jed  
May, 2008 Goldschmidt Luki  
April, 2008 Meytal Landau  
March 11th, 2008
4:00 PM		 Zhao Ming Lei Amyloid toxicity is independent of polypeptide sequence, length and chirality. [J. Mol. Biol. 375, 695-707 (2008)] [PDF]
March, 2008 Arthur Laganowsky  
February 13th, 2008
4:00 PM		 Magdalena Ivanova Amyloid fibril formation and chaperone-like activity of peptides from aACrystallin [Biochemistry 47, 2961-2967 (2008)] [PDF]
January 9th, 2008
4:00 PM		 Stuart Sievers Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions. [J Biol Chem 282, 34204-12 (2007)] [PDF]
November, 2007 Colletier Jacque  
October 10th, 2007
4:00 PM		 Michael Sawaya Design of Peptides That Form Amyloid-Like Fibrils Capturing Amyloid beta1-42 Peptides. [Chemistry 13, 7745-7752 (2007)]
September 12th, 2007
4:00 PM		 Majumdar Devdoot The structural basis of yeast prion strain variants [Nature Epub, (2007)] [PDF]
August 8th, 2007
4:00 PM		 Rebecca Nelson Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. [Biochemistry 46, 8850-886 (2007)] [PDF]
July 11th, 2007
4:00 PM		 Zhefeng Guo Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: A possible general mechanism for familial ALS [Proc Natl Acad Sci U S A. 104, 11263-11267 (2007)] [PDF]
June, 2007 Wiltzius Jed Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm [Biochimica et Biophysica Acta , (2007)]
May, 2007 Heather McFarlane  
April 11th, 2007
4:00 PM		 Marcin Apostol Small molecule inhibitors of aggregation indicate that amyloid Beta oligomerization and fibrillization pathways are independent and distinct. [J. Biol. Chem. 282, 10311-24 (2007)] [PDF]
March, 2007 Stroud James Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. [J. Biol. Chem. , Epub ahead of print (2007)] [PDF]
February 14th, 2007
4:00 PM		 Goldschmidt Luki Insight into the Structure of Amyloid Fibrils from the Analysis of Globular Proteins. [PLoS Computational Biology 2, e170 (2007)] [PDF]
January 10th, 2007
4:00 PM		 Magdalena Ivanova Prediction of Amyloidogenic and Disordered Regions in Protein Chains. [PLoS Computational Biology 2, 177 (2006)] [PDF]
December 13th, 2006
4:00 PM		 Stuart Sievers 3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR. [Proc Natl Acad Sci U S A. 103, 18119-24 (2006)] [PDF]
November 8th, 2006
4:00 PM		 Michael Sawaya General structural motifs of amyloid protofilaments. [Proc Natl Acad Sci U S A. 103, 16248-53 (2006)] [PDF]
October, 2006 Balbirnie Melinda Presents her own research
September 13th, 2006
4:00 PM		 Rebecca Nelson Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. [Molecular Cell 23, 425-438 (2006)] [PDF]
August 9th, 2006
4:00 PM		 Shilpa Sambashivan Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. [Science 313, 324-8 (2006)] [PDF]
July 12th, 2006
4:00 PM		 Majumdar Devdoot The physical basis of how prion conformations determine strain phenotypes. [Nature Epub, (2006)] [PDF]
June, 2006 Michael Thompson Update on interesting research presented at FASEB conference on amyloid and protein misfolding
May 10th, 2006
4:00 PM		 Zhefeng Guo Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. [Biochemistry 45, 5503-16 (2006)] [PDF]
April 12th, 2006
4:00 PM		 Jason Forse The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-production [Nature 440, 528-534 (2006)] [PDF]
March 8th, 2006
4:00 PM		 Wiltzius Jed Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as a nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis [PNAS 103, 1046-2051 (2006)] [PDF]
February 8th, 2006
4:00 PM		 Heather McFarlane Annealing prion protein amyloid fibrils at high temperature results in extension of a proteinase K-resistant core. [J. Biol. Chem. 281, 2373-2379 (2006)] [PDF]
January, 2006 Sampogna Rosemary Talk about clinical aspects of amyloidosis
December 7th, 2005
4:00 PM		 Marcin Apostol Functional Amyloid Formation within Mammalian Tissue. [PLoS Biology 4, e6 (2005)] [PDF]
November 9th, 2005
4:00 PM		 Stuart Sievers The amyloid stretch hypothesis: Recruiting proteins toward the dark side [PNAS 102, 16672-16677 (2005)] [PDF]
October 12th, 2005
4:00 PM		 Magdalena Ivanova 3D domain-swapped human cystatin C with amyloidlike intermolecular -sheets [Proteins Sept 16, Epub ahead of print (2005)] [PDF]
September 14th, 2005
2:00 PM		 Shilpa Sambashivan The most infectious prion protein particles. [Nature 437, 257-61 (2005)] [PDF]
August, 2005 Michael Sawaya ?
July, 2005 NO MEETING  
June 8th, 2005
4:00 PM		 Balbirnie Melinda Amyloid formation modulates the biological activity of a bacterial protein. [J. Boil. Chem. 280, 26880-26885 (2005)] [PDF]
May 11th, 2005
4:30 PM		 Michael Thompson In vitro generation of infectious scrapie prions. [Cell 121, 195-202 (2005)] [PDF]
April 13th, 2005
4:00 PM		 David Eisenberg Fibril Conformation as the Basis of Species and Strain-Dependent Seeding Specificity of Mammalian Prion Amyloids [Cell 121, 63-72 (2005)] [PDF]
March 9th, 2005
4:00 PM		 Rebecca Nelson Amyloid Fibril Formation from Sequences of a Natural beta-Structured [J. Biol. Chem. 280, 2481-2490 (2005)] [PDF]
February 9th, 2005
2:00 PM		 Bennet Brewer Melanie In vitro Conversion fo Full-length Mammalian Protein Produces Amyloid Form with Physical Properties of PrPSC [J. Mol. Boil. 346, 645-659 (2005)] [PDF]
January 12th, 2005
4:00 PM		 Mari Gingery Amyloidogenic Self-Assembly of Insulin Aggregates Probed by High Resolution [Biophys J. 88, 1344-53 (2005)] [PDF]
December 9th, 2004
2:00 PM		 Marcin Apostol Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation [Science 306(5697), 865-9 (2004)] [PDF]
November, 2004 Rebecca Nelson Rebecca and Mikey give us highlights of the peptide structure
October 13th, 2004
4:30 PM		 Zhefeng Guo Mechanism of Prion Propagation: Amyloid Growth Occurs by Monomer Addition [PLoS Biology 2:10, 1582-90 (2004)] [PDF]
September, 2004 None On Hiatus this month
August 11th, 2004
4:30 PM		 Janel Laidman Synthetic Mammalian Prions [Science 305, 673-676 (2004)] [PDF]
July 28th, 2004
4:30 PM		 Shilpa Sambashivan Insight into the PrPC PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants [PNAS 101, 10254-10259 (2004)] [PDF]
June 9th, 2004
4:30 PM		 Michael Sawaya A model for Ure2p prion filaments and other amyloids: the parallel superpleated beta-structure. [PNAS 101, 7885-90 (2004)] [PDF]
May 29th, 2004
4:30 PM		 Rebecca Nelson Short amino acid stretches can mediate amyloid formation in globular proteins: The Src homology 3 (SH3) case [PNAS 101, 7258-7263 (2004)] [PDF]
April 14th, 2004
4:30 PM		 Magdalena Ivanova Dissection and Design of Yeast Prions [PLoS Biol. 2, 442-450 (2004)] [PDF]
March 3rd, 2004
4:30 PM		 David Eisenberg Beta-Helix is a likely core structure of yeast prion Sup35 amyloid fibers [Biochem. Biophys. Res. Comm. 315, 739-745 (2004)] [PDF]
February 11th, 2004
4:30 PM		 Mike Thompson Mapping Abeta amyloid fibril secondary structure using scanning proline mutagenesis [J. Mol. Biol. 335, 833-842 (2004)] [PDF]
January 14th, 2004
4:30 PM		 Sangho Lee Sequence determinants of amyloids firbril formation [PNAS 101, 87-92 (2004)] [PDF]
November 25th, 2003
4:30 PM		 Janel Laidman Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis [Science 302, 871-874 (2003)] [PDF]
October 15th, 2003
4:30 PM		 Shilpa Sambashivan Nucleation-dependent conformational conversion of the Y145Stop variant of human prion protein: Structural clues for prion propagation [PNAS 100, 12069-12074 (2003)] [PDF]
September 17th, 2003
4:30 PM		 Michael Sawaya Rationalization of the effects of mutations on peptide and protein aggregation rates [Nature 424, 805-808 (2003)] [PDF]
Generation of prion transmission barriers by mutational control of amyloid conformations [Nature 424, 948-951 (2003)] [PDF]
August 13th, 2003
4:30 PM		 Sangho Lee A general model for amyloid fibril assembly based on morphological studies using atomic formce microscopy [Biophys. J. 85, 1135-1144 (2003)] [PDF]
July 9th, 2003
4:30 PM		 Janel Laidman Site-specific identification of non-beta-strand conformation in Alzheimer's beta-amyloid fibrils by solid-state NMR [Biophys. J. 84, 3326-3335 (2003)] [PDF]
June 11th, 2003
4:30 PM		 Magdalena Ivanova Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familia ALS [Nat. Struct. Biol. 10, 461-467 (2003)] [PDF]
May 14th, 2003
4:30 PM		 Shilpa Sambashivan Domain organization and structure-function relationship of the HET-s prion protein of Podospora anserian [EMBO J. 22, 2071-2081 (2003)] [PDF]
April 16th, 2003
4:30 PM		 Rebecca Nelson Assemblies of Alzheimer's peptides Abeta25-35 and Abeta31-35: reverse-turn conformation and side-chain interactions revealed by X-ray diffraction [J. Struct. Biol. 141, 157-170 (2003)] [PDF]
March 12th, 2003
4:30 PM		 David Eisenberg Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance [Biochemistry 41, 15436-15450 (2002)] [PDF]
A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR [PNAS 99, 16742-16747 (2002)] [PDF]
February 12th, 2003
4:30 PM		 Greg Payne Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders [Nature 421, 373-379 (2003)] [PDF]
January 15th, 2003
4:30 PM		 Ahmed Serag Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases [PNAS 99, 16419-16426 (2002)] [PDF]
November 20th, 2002
4:30 PM		 Rob Grothe The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation [EMBO J. 21, 5682-5690 (2002)] [PDF]
October 10th, 2002
4:30 PM		 Rebecca Nelson Insufficient hydrogen-bond desolvation and prion-related disease [Eur. J. Biochem. 269, 4165-4168 (2002)] [PDF]
September 5th, 2002
4:30 PM		 Shilpa Sambashivan Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation [Proc. Natl. Acad. Sci. USA 99, 11884-11889 (2002)] [PDF]
August 6th, 2002
4:30 PM		 Charlotte Deane A designed system for assessing how sequence affects alpha to beta conformational transitions in proteins [J. Biol. Chem. 277, 10150-10155 (2002)] [PDF]
June 11th, 2002
4:30 PM		 Magdalena Ivanova The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro [EMBO J. 21, 2903-2911 (2002)] [PDF]
June 11th, 2002
4:30 PM		 David Eisenberg Purification and properties of the cellular and scrapie hamster prion proteins [Eur. J. Biochem. 176, 21-30 (1988)] [PDF]
The importance of the disulfide bond in prion protein conversion [NeuroReport 9, 2457-2461 (1998)] [PDF]
A role for intermolecular disulfide bonds in prion diseases? [PNAS 98, 4334-4336 (2001)] [PDF]
May 14th, 2002
4:30 PM		 Sangho Lee Inaugural Article: Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein [PNAS 99, 5253-5260 (2002)] [PDF]
April 9th, 2002
4:30 PM		 Yanshun Liu Structural studies of the scrapie prion protein by electron crystallography [PNAS 99, 3563-3568 (2002)] [PDF]
March 12th, 2002
4:30 PM		 Rebecca Nelson Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) to contiguous membranes [EMBO J. 21, 1031-1040 (2002)] [PDF]
February 12th, 2002
12:00 AM		 Sangho Lee The HET-s prion protein of the filamentous fungus Podospora anserian aggregates in vitro into amyloid-like fibrils [J. Biol. Chem. 277, 5703-5706 (2002)] [PDF]
January 15th, 2002
4:30 PM		 Magdalena Ivanova Strains of [PSI+] are distinguished by their efficiencies of prion-mediated conformational conversion [EMBO J. 20, 6236-6245 (2001)] [PDF]
Yeast prion protein derivative defective in aggregate shearing and production of new 'seeds' [EMBO J. 20, 6683-6691 (2001)] [PDF]
December 11th, 2001
4:30 PM		 Charlotte Deane Investigation of a peptide responsible for amyloid fibril formation of beta-2-microglobulin by acromobacter protease I [J. Biol. Chem. 277, 1310-1315 (2002)] [PDF]
November 13th, 2001
4:30 PM		 Sangho Lee The role of conformational flexibility in prion propagation and maintenance for Sup35p [Nature Structural Biology 8, 958-962 (2001)] [PDF]
October, 2001 Sangho Lee Cancelled
September 11th, 2001
4:30 PM		 Rebecca Nelson Three-dimensional domain swapping in the folded and molten-globule states of cystatins an amyloid-forming structural superfamily [EMBO J. 20, 4774-4781 (2001)] [PDF]
August 21st, 2001
4:30 PM		 Yanshun Liu (list)/ Daniel Song (presentation) Prion affects the appearance of other prions: the story of [PIN+] [Cell 106, 171-182 (2001)] [PDF]
Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI+] prion [Cell 106, 183-194 (201)] [PDF]
June 12th, 2001
4:30 PM		 Sangho Lee Inhibition of interactions and interconversions of prion protein isoforms by peptides fragments from the C-terminal folded domain [J. Biol. Chem. 276, 15489-15497 (2001)] [PDF]
May 8th, 2001
4:30 PM		 Magdalena Ivanova Conformational diversity in a yeast prion dictates its seeding specificity [Nature 410, 223-227 (2001)] [PDF]
April 3rd, 2001
4:30 PM		 Sangho Lee Human cystatin C an amyloidogenic protein dimerizes through three-dimensional domain swapping [Nature Structural Biology 8, 316-320 (2001)] [PDF]
March 6th, 2001
4:30 PM		 Rebecca Nelson Mapping the early steps in the pH-induced conformational conversion of the prion protein [PNAS 98, 2985-2989 (2001)] [PDF]
January 6th, 2001
4:30 PM		 Yanshun Liu Mutational analysis of designed peptides that undergo structural transition from alpha-helix to beta-sheet and amyloid fibril formation [Structure 8, 915-925 (2000)] [PDF]
December 5th, 2000
4:30 PM		 Ahmed Serag The beta-Slip: A Novel Concept in Transthyretin Amyloidosis [Molecular Cell 6, 1207-1218 (2000)] [PDF]
November 7th, 2000
4:30 PM		 Sangho Lee Characterization of the Oligomeric States of Insulin in Self-Assembly and Amyloid Fibril Formation by Mass Spectrometry [Biophys. J. 79, 1053-1065 (2000)] [PDF]
October 3rd, 2000
4:30 PM		 Rebecca Nelson Is Oxidative Damage by b-Amyloid and Prion Peptides Mediated by Hydrogen Atom Transfer from Glycine a-Carbon to Methionine Sulfur within b-Sheets? [J. Am. Chem. Soc. 122, 9761-9767 (2000)] [PDF]
September 6th, 2000
4:30 PM		 Rob Grothe Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant [Science 289, 1317-1321 (2000)] [PDF]
August 15th, 2000
4:30 PM		 Magdalena Ivanova Evidence for the Prion Hypothesis: Induction of the Yeast [PSI+] Factor by in Vitro-Converted Sup35 Protein [Science 289, 595-599 (2000)] [PDF]
July 11th, 2000
4:30 PM		 Aaron Chamberlain Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1 [Nature 405, 689-694 (2000)] [PDF]
June 6th, 2000
4:30 PM		 Melinda Balbirnie The prion domain of yeast Ure2p induces autocatalytic formation of amyloid fibers by a recombinant fusion protein [Protein Science 9, 440-451 (2000)] [PDF]
May 2nd, 2000
4:30 PM		 Yanshun Liu Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease [Cell 101, 57-66 (2000)] [PDF]
April 4th, 2000
4:30 PM		 Sangho Lee Fibrils Formed in Vitro from alpha-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid [Biochemistry 39, 2552-2563 (2000)] [PDF]
March 7th, 2000
4:30 PM		 Magdalena Ivanova Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells [Proc. Natl. Acad. Sci. USA 96, 11404-11409 (1999)] [PDF]
February 1st, 2000
4:30 PM		 Ahmed Serag Molecular Basis of a Yeast Prion Species Barrier [Cell 100, 277-288 (2000)] [PDF]
January 11th, 2000
4:30 PM		 Melinda Balbirnie Rapid protein-folding assay using green fluorescent protein [Nature Biotechnology 17, 691-695 (1999)] [PDF]
December 7th, 1999
4:30 PM		 Yanshun Liu Assembly of Abeta Amyloid Protofibrils: An in Vitro Model for a Possible Early Event in Alzheimer's Disease [Biochemistry 38, 8972-8980 (1999)] [PDF]
August 10, 1999 Magdalena Ivanova
Sangho Lee		 Posters presented in the 13th Protein Society Symposium
September 7, 1999 Ahmed Serag Working definition of amyloid
October 12, 1999 Magdalena Ivanova Another mechanism of amyloid formation
November 2, 1999 Sangho Lee Determinants for amyloidogenicity

 

The amyloids mailing list: amyloidsrus@mbi.ucla.edu

Apostol, Marcin
Devdoot, Majumdar
Eisenberg, David
Gingery, Mari
Ivanova, Magdalena
Jacque, Colletier
James, Stroud
Jed, Wiltzius
Laganowsky, Arthur
Laidman, Janel
Landau, Meytal
Luki, Goldschmidt
McFarlane, Heather
Melinda, Balbirnie
Ming Lei, Zhao
Nelson, Rebecca
Rosemary, Sampogna
Sawaya, Michael
Shimon, Weiss
Sievers, Stuart
Yeates, Todd
Zhefeng Guo,

 

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