This turn is really exciting,for here we can see some practical uses of bioinformatics analysis of AS which can be apt to the bench workers thoughts and gives a new perspective for us.
Question: what is the current focusing of AS except its tissue specificity,any other specificity interesting ?

Alternative splicing can also be tightly regulated by developmental states. It can also have strong association with diseases ( e.g. cancer). All these are interesting subjects for studies.

Nice response. And since you claim that AS is related to such as development,dieases, etc, then can computation be useful for these work? And how?

joke: only statistics?

sure. if someone classifies the EST libraries based on developmental states, he can do the same kind of analysis for detecting tissue-specificity, as long as there is enough EST counts for libraries with development-state information.

And experimental work can follow computational discoveries.