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BMC Structural Biology - Latest Articles   [more] [xml]
 2014-10-18T00:00:00Z A PDB-wide, evolution-based assessment of protein¿protein interfaces
Background: Thanks to the growth in sequence and structure databases, more than 50 million sequences are now available in UniProt and 100,000 structures in the PDB. Rich information about protein?protein interfaces can be obtained by a comprehensive study of protein contacts in the PDB, their sequence conservation and geometric features. Results: An automated computational pipeline was developed to run our Evolutionary Protein?Protein Interface Classifier (EPPIC) software on the entire PDB and store the results in a relational database, currently containing > 800,000 interfaces. This allows the analysis of interface data on a PDB-wide scale. Two large benchmark datasets of biological interfaces and crystal contacts, each containing about 3000 entries, were automatically generated based on criteria thought to be strong indicators of interface type. The BioMany set of biological interfaces includes NMR dimers solved as crystal structures and interfaces that are preserved across diverse crystal forms, as catalogued by the Protein Common Interface Database (ProtCID) from Xu and Dunbrack. The second dataset, XtalMany, is derived from interfaces that would lead to infinite assemblies and are therefore crystal contacts. BioMany and XtalMany were used to benchmark the EPPIC approach. The performance of EPPIC was also compared to classifications from the Protein Interfaces, Surfaces, and Assemblies (PISA) program on a PDB-wide scale, finding that the two approaches give the same call in about 85% of PDB interfaces. By comparing our safest predictions to the PDB author annotations, we provide a lower-bound estimate of the error rate of biological unit annotations in the PDB. Additionally, we developed a PyMOL plugin for direct download and easy visualization of EPPIC interfaces for any PDB entry. Both the datasets and the PyMOL plugin are available at http://www.eppic-web.org/ewui/\#downloads. Conclusions: Our computational pipeline allows us to analyze protein?protein contacts and their sequence conservation across the entire PDB. Two new benchmark datasets are provided, which are over an order of magnitude larger than existing manually curated ones. These tools enable the comprehensive study of several aspects of protein?protein contacts in the PDB and represent a basis for future, even larger scale studies of protein?protein interactions.


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BMC Bioinformatics - Latest Articles   [more] [xml]
 2014-10-22T00:00:00Z SummonChimera infers integrated viral genomes with nucleotide precision from NGS data
Background: Viral integration into a host genome is defined by two chimeric junctions that join viral and host DNA. Recently, computational tools have been developed that utilize NGS data to detect chimeric junctions. These methods identify individual viral-host junctions but do not associate chimeric pairs as an integration event. Without knowing the chimeric boundaries of an integration, its genetic content cannot be determined. Results: Summonchimera is a Perl program that associates chimera pairs to infer the complete viral genomic integration event to the nucleotide level within single or paired-end NGS data. SummonChimera integration prediction was verified on a set of single-end IonTorrent reads from a purified Salmonella bacterium with an integrated bacteriophage. Furthermore, SummonChimera predicted integrations from experimentally verified Hepatitis B Virus chimeras within a paired-end Whole Genome Sequencing hepatocellular carcinoma tumor database. Conclusions: SummonChimera identified all experimentally verified chimeras detected by current computational methods. Further, SummonChimera integration inference precisely predicted bacteriophage integration. The application of SummonChimera to cancer NGS accurately identifies deletion of host and viral sequence during integration. The precise nucleotide determination of an integration allows prediction of viral and cellular gene transcription patterns.


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BMC Genomics - Latest Articles   [more] [xml]
 2014-10-22T00:00:00Z Transcriptome profiling using pyrosequencing shows genes associated with bast fiber development in ramie (Boehmeria nivea L.)
Background: Ramie (Boehmeria nivea L.), popularly known as "China grass", is one of the oldest crops in China and the second most important fiber crop in terms of area sown. Ramie fiber, extracted from the plant bast, is important in the textile industry. However, the molecular mechanism of ramie fiber development remains unknown. Results: A whole sequencing run was performed on the 454 GS FLX + platform using four separately pooled parts of ramie bast. This generated 1,030,057 reads with an average length of 457 bp. Among the 58,369 unigenes (13,386 contigs and 44,983 isotigs) that were generated through de novo assembly, 780 were differentially expressed. As a result, 13 genes that belong to the cellulose synthase gene family (four), the expansin gene family (three) and the xyloglucan endotransglucosylase/ hydrolase (XTH) gene family (six) were up-regulated in the top part of the bast, which was in contrast to the other three parts. The identification of these 13 concurrently up-regulated unigenes indicated that the early stage (represented by the top part of the bast) might be important for the molecular regulation of ramie fiber development. Further analysis indicated that four of the 13 unigenes from the expansin (two) and XTH (two) families shared a coincident expression pattern during the whole growth season, which implied they were more relevant to ramie fiber development (fiber quality, etc.) during the different seasons than the other genes. Conclusions: To the best of our knowledge, this study is the first to characterize ramie fiber development at different developmental stages. The identified transcripts will improve our understanding of the molecular mechanisms involved in ramie fiber development. Moreover, the identified differentially expressed genes will accelerate molecular research on ramie fiber growth and the breeding of ramie with better fiber yields and quality.


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BMC Biochemistry - Latest Articles   [more] [xml]
 2014-10-09T00:00:00Z Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with l-tyrosine and l-DOPA
Background: Hydroxyl radical that has the highest reactivity among reactive oxygen species (ROS) is generated through l-tyrosine-tyrosinase reaction. Thus, the melanogenesis might induce oxidative stress in the skin. Arbutin (p-hydroxyphenyl-β-d-glucopyranoside), a well-known tyrosinase inhibitor has been widely used for the purpose of skin whitening. The aim of the present study was to examine if arbutin could suppress the hydroxyl radical generation via tyrosinase reaction with its substrates, l-tyrosine and l-DOPA. Results: The hydroxyl radical, which was determined by an electron spin resonance-spin trapping technique, was generated by the addition of not only l-tyrosine but l-DOPA to tyrosinase in a concentration dependent manner. Arbutin could inhibit the hydroxyl radical generation in the both reactions. Conclusion: It is presumed that arbutin could alleviate oxidative stress derived from the melanogenic pathway in the skin in addition to its function as a whitening agent in cosmetics.


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Nature   [more] [xml]
 2005-01-19 Einstein is dead
Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.

Einstein is dead

Nature 433, 179 (2005). doi:10.1038/433179a

Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.



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Science: Current Issue   [more] [xml]
 2014-10-17 [Special Issue Report] On the prevalence of small-scale twist in the solar chromosphere and transition region
The solar chromosphere and transition region (TR) form an interface between the Sun’s surface and its hot outer atmosphere. There, most of the nonthermal energy that powers the solar atmosphere is transformed into heat, although the detailed mechanism remains elusive. High-resolution (0.33–arc second) observations with NASA’s Interface Region Imaging Spectrograph (IRIS) reveal a chromosphere and TR that are replete with twist or torsional motions on sub–arc second scales, occurring in active regions, quiet Sun regions, and coronal holes alike. We coordinated observations with the Swedish 1-meter Solar Telescope (SST) to quantify these twisting motions and their association with rapid heating to at least TR temperatures. This view of the interface region provides insight into what heats the low solar atmosphere. Authors: B. De Pontieu, L. Rouppe van der Voort, S. W. McIntosh, T. M. D. Pereira, M. Carlsson, V. Hansteen, H. Skogsrud, J. Lemen, A. Title, P. Boerner, N. Hurlburt, T. D. Tarbell, J. P. Wuelser, E. E. De Luca, L. Golub, S. McKillop, K. Reeves, S. Saar, P. Testa, H. Tian, C. Kankelborg, S. Jaeggli, L. Kleint, J. Martinez-Sykora
 2014-10-17 [Special Issue Report] The unresolved fine structure resolved: IRIS observations of the solar transition region
The heating of the outer solar atmospheric layers, i.e., the transition region and corona, to high temperatures is a long-standing problem in solar (and stellar) physics. Solutions have been hampered by an incomplete understanding of the magnetically controlled structure of these regions. The high spatial and temporal resolution observations with the Interface Region Imaging Spectrograph (IRIS) at the solar limb reveal a plethora of short, low-lying loops or loop segments at transition-region temperatures that vary rapidly, on the time scales of minutes. We argue that the existence of these loops solves a long-standing observational mystery. At the same time, based on comparison with numerical models, this detection sheds light on a critical piece of the coronal heating puzzle. Authors: V. Hansteen, B. De Pontieu, M. Carlsson, J. Lemen, A. Title, P. Boerner, N. Hurlburt, T. D. Tarbell, J. P. Wuelser, T. M. D. Pereira, E. E. De Luca, L. Golub, S. McKillop, K. Reeves, S. Saar, P. Testa, H. Tian, C. Kankelborg, S. Jaeggli, L. Kleint, J. Martínez-Sykora
 2014-10-17 [Special Issue Report] Hot explosions in the cool atmosphere of the Sun
The solar atmosphere was traditionally represented with a simple one-dimensional model. Over the past few decades, this paradigm shifted for the chromosphere and corona that constitute the outer atmosphere, which is now considered a dynamic structured envelope. Recent observations by the Interface Region Imaging Spectrograph (IRIS) reveal that it is difficult to determine what is up and down, even in the cool 6000-kelvin photosphere just above the solar surface: This region hosts pockets of hot plasma transiently heated to almost 100,000 kelvin. The energy to heat and accelerate the plasma requires a considerable fraction of the energy from flares, the largest solar disruptions. These IRIS observations not only confirm that the photosphere is more complex than conventionally thought, but also provide insight into the energy conversion in the process of magnetic reconnection. Authors: H. Peter, H. Tian, W. Curdt, D. Schmit, D. Innes, B. De Pontieu, J. Lemen, A. Title, P. Boerner, N. Hurlburt, T. D. Tarbell, J. P. Wuelser, Juan Martínez-Sykora, L. Kleint, L. Golub, S. McKillop, K. K. Reeves, S. Saar, P. Testa, C. Kankelborg, S. Jaeggli, M. Carlsson, V. Hansteen
 2014-10-17 [Special Issue Report] Evidence of nonthermal particles in coronal loops heated impulsively by nanoflares
The physical processes causing energy exchange between the Sun’s hot corona and its cool lower atmosphere remain poorly understood. The chromosphere and transition region (TR) form an interface region between the surface and the corona that is highly sensitive to the coronal heating mechanism. High-resolution observations with the Interface Region Imaging Spectrograph (IRIS) reveal rapid variability (~20 to 60 seconds) of intensity and velocity on small spatial scales (≲500 kilometers) at the footpoints of hot and dynamic coronal loops. The observations are consistent with numerical simulations of heating by beams of nonthermal electrons, which are generated in small impulsive (≲30 seconds) heating events called “coronal nanoflares.” The accelerated electrons deposit a sizable fraction of their energy (≲1025 erg) in the chromosphere and TR. Our analysis provides tight constraints on the properties of such electron beams and new diagnostics for their presence in the nonflaring corona. Authors: P. Testa, B. De Pontieu, J. Allred, M. Carlsson, F. Reale, A. Daw, V. Hansteen, J. Martinez-Sykora, W. Liu, E. E. DeLuca, L. Golub, S. McKillop, K. Reeves, S. Saar, H. Tian, J. Lemen, A. Title, P. Boerner, N. Hurlburt, T. D. Tarbell, J. P. Wuelser, L. Kleint, C. Kankelborg, S. Jaeggli
 2014-10-17 [Review] Evolution of responses to (un)fairness
The human sense of fairness is an evolutionary puzzle. To study this, we can look to other species, in which this can be translated empirically into responses to reward distribution. Passive and active protest against receiving less than a partner for the same task is widespread in species that cooperate outside kinship and mating bonds. There is less evidence that nonhuman species seek to equalize outcomes to their own detriment, yet the latter has been documented in our closest relatives, the apes. This reaction probably reflects an attempt to forestall partner dissatisfaction with obtained outcomes and its negative impact on future cooperation. We hypothesize that it is the evolution of this response that allowed the development of a complete sense of fairness in humans, which aims not at equality for its own sake but for the sake of continued cooperation. Authors: Sarah F. Brosnan, Frans B. M. de Waal
 2014-10-17 [Special Issue Report] Prevalence of small-scale jets from the networks of the solar transition region and chromosphere
As the interface between the Sun’s photosphere and corona, the chromosphere and transition region play a key role in the formation and acceleration of the solar wind. Observations from the Interface Region Imaging Spectrograph reveal the prevalence of intermittent small-scale jets with speeds of 80 to 250 kilometers per second from the narrow bright network lanes of this interface region. These jets have lifetimes of 20 to 80 seconds and widths of ≤300 kilometers. They originate from small-scale bright regions, often preceded by footpoint brightenings and accompanied by transverse waves with amplitudes of ~20 kilometers per second. Many jets reach temperatures of at least ~105 kelvin and constitute an important element of the transition region structures. They are likely an intermittent but persistent source of mass and energy for the solar wind. Authors: H. Tian, E. E. DeLuca, S. R. Cranmer, B. De Pontieu, H. Peter, J. Martínez-Sykora, L. Golub, S. McKillop, K. K. Reeves, M. P. Miralles, P. McCauley, S. Saar, P. Testa, M. Weber, N. Murphy, J. Lemen, A. Title, P. Boerner, N. Hurlburt, T. D. Tarbell, J. P. Wuelser, L. Kleint, C. Kankelborg, S. Jaeggli, M. Carlsson, V. Hansteen, S. W. McIntosh
 2014-10-17 [Review] Applying evolutionary biology to address global challenges
Two categories of evolutionary challenges result from escalating human impacts on the planet. The first arises from cancers, pathogens, and pests that evolve too quickly and the second, from the inability of many valued species to adapt quickly enough. Applied evolutionary biology provides a suite of strategies to address these global challenges that threaten human health, food security, and biodiversity. This Review highlights both progress and gaps in genetic, developmental, and environmental manipulations across the life sciences that either target the rate and direction of evolution or reduce the mismatch between organisms and human-altered environments. Increased development and application of these underused tools will be vital in meeting current and future targets for sustainable development. Authors: Scott P. Carroll, Peter Søgaard Jørgensen, Michael T. Kinnison, Carl T. Bergstrom, R. Ford Denison, Peter Gluckman, Thomas B. Smith, Sharon Y. Strauss, Bruce E. Tabashnik
 2014-10-17 [Editorial] “Epicenters” of resilience
The 25th anniversary of the magnitude (M) 6.9 Loma Prieta earthquake that struck the San Francisco Bay Area on 17 October 1989 is a fitting time to examine what progress has been made in increasing community resilience to minimize seismic risk. The regions affected by the 2010 M 7.0 earthquake that struck Port-au-Prince, Haiti, and the M 8.8 event near Concepción, Chile, a few weeks later illustrate the extremes in earthquake resilience. In the zone of most intense shaking, 1 of every 10 Haitians was killed, compared to 1 of every 2500 Chileans, reflecting huge differences in construction quality and community resilience. The Loma Prieta event left 63 people dead, largely the result of the collapse of a bridge, an overpass, and homes built on unconsolidated fill. But beyond the loss of life, the Bay Area was affected by more than $10 billion in disruption of economic activity and damaged infrastructure. One challenge in implementing community resilience is to use science and engineering to find solutions that not only save lives but also get communities back to business as quickly as possible after a seismic event. Author: Mary Lou Zoback
 2014-10-17 [In Brief] This week's section
A roundup of weekly science policy and related news.
 2014-10-17 [In Depth] For Venezuelan academics, speaking out is risky business
Government attacks some, snares many in red tape. Author: Lizzie Wade
 2014-10-17 [In Depth] ‘Nonadherence’: A bitter pill for drug trials
Drug developers seek new ways to ensure that subjects take their medicine. Author: Kelly Servick
 2014-10-17 [In Depth] Ebola vaccine trials raise ethical issues
Randomized studies may offer fastest answer. Authors: Jon Cohen, Kai Kupferschmidt
 2014-10-17 [In Depth] Light loophole wins laurels
Chemistry prize winners pushed microscopes past supposed limit. Author: Daniel Clery
 2014-10-17 [In Depth] Regulating industry's big boys
French economist Jean Tirole is honored for his analyses of oligopolies. Author: Tania Rabesandratana
 2014-10-17 [Feature] Baboon watch
An epic baboon study shows how social interactions shape health and reproduction in all primates—including humans. Author: Elizabeth Pennisi
 2014-10-17 [Feature] The baboon chronicles
Amboseli researchers have monitored their subjects for 40 years.
 2014-10-17 [Policy Forum] Changes on the horizon for consumer genomics in the EU
Test results may no longer be available directly to consumers Authors: Louiza Kalokairinou, Heidi Carmen Howard, Pascal Borry
 2014-10-17 [Perspective] To learn is to myelinate
The adult mammalian brain requires the production of new glial cells and myelin for learning Authors: Patrick Long, Gabriel Corfas
 2014-10-17 [Perspective] Nutrient computation for root architecture
Plants sense and respond to nutrients using a peptide signaling system Authors: Ton Bisseling, Ben Scheres
 2014-10-17 [Perspective] Sensing biodiversity
Sophisticated networks are required to make the best use of biodiversity data from satellites and in situ sensors Author: Woody Turner
 2014-10-17 [Perspective] Potassium ions line up
Do K+ ions move in single file through potassium channels? Author: Gerhard Hummer
 2014-10-17 [Perspective] In optical pumping, less can be more
Creating loss in one optical resonator can initiate lasing in its coupled partner Author: Harald G. L. Schwefel
 2014-10-17 [Perspective] Looking closer at the Sun
The space-based IRIS telescope provides a new window to view the solar atmosphere Author: Louise K. Harra
 2014-10-17 [Book Review] When race counts
Author: Paul Schor
 2014-10-17 [Books et al.] Books Received
A listing of books received at Science during the week ending 10 October 2014.
 2014-10-17 [Letter] Before the Kardashian Index
Author: Gregory R. Goldsmith
 2014-10-17 [Letter] Nuanced negative result reporting
Authors: Stefan K. Lhachimi, David Lehrer, Janine Leschke, Moira Nelson, Brigitte Weiffen
 2014-10-17 [Letter] Support underway for coastal ecosystems
Author: Dustin S. Schinn
 2014-10-17 [Letter] Science and religion: Think local
Author: Jonathan M. Hanes
 2014-10-17 This Week in Science
Tornadoes clustering in greater numbers | What's inside Saturn's tiniest moon? | Detoxing drug overdoses with nanoparticles | Ensuring a one-way flow of lymph | A thorny defense keeps grazers at bay | Complex light and matter interactions | Smart monkeys can outwit a computer | Ions knock each other across the membrane | Finding the targets of T cells gone bad | Exploiting evolution for humanity's sake | Learning requires the brain to change | The evolutionary benefits of behaving fairly | Stellar outflows replicated in miniature | Achieving gain despite increasing loss | A very quick look at phenylalanine | Getting to the root of a root problem | Insight into a retinal degeneration disease | Cytoskeleton protects from stress and aging
 2014-10-17 Editors' Choice
Charting the course of antibiotic failure | Protein sorting sets digit number | Unraveling ringwoodite hydration in mantle | Meat-eater lived in extinction's wake | A costly reluctance to speak out | How many lakes are there on Earth? | Taking the temperature of virulence | Finding ways to reach the right endpoint
 2014-10-17 [Introduction to Special Issue] Probing the solar interface region
Authors: Bart De Pontieu, Alan Title, Mats Carlsson
 2014-10-17 [Research Article] Motor skill learning requires active central myelination
Mice need myelinating cells in the brain to master an unpredictable motor task. [Also see Perspective by Long and Corfas] Authors: Ian A. McKenzie, David Ohayon, Huiliang Li, Joana Paes de Faria, Ben Emery, Koujiro Tohyama, William D. Richardson
 2014-10-17 [Report] Constraints on Mimas’ interior from Cassini ISS libration measurements
The precise difference between rotational and orbital periods suggests an unexpected interior for one of Saturn’s moons. Authors: R. Tajeddine, N. Rambaux, V. Lainey, S. Charnoz, A. Richard, A. Rivoldini, B. Noyelles
 2014-10-17 [Report] Laboratory formation of a scaled protostellar jet by coaligned poloidal magnetic field
A scaled-down plasma experiment shows that axial magnetic fields in young stars can shape their bipolar jet outflows. Authors: B. Albertazzi, A. Ciardi, M. Nakatsutsumi, T. Vinci, J. Béard, R. Bonito, J. Billette, M. Borghesi, Z. Burkley, S. N. Chen, T. E. Cowan, T. Herrmannsdörfer, D. P. Higginson, F. Kroll, S. A. Pikuz, K. Naughton, L. Romagnani, C. Riconda, G. Revet, R. Riquier, H.-P. Schlenvoigt, I. Yu. Skobelev, A.Ya. Faenov, A. Soloviev, M. Huarte-Espinosa, A. Frank, O. Portugall, H. Pépin, J. Fuchs
 2014-10-17 [Report] Loss-induced suppression and revival of lasing
Introducing loss into a coupled optical system can result in an enhancement of the optical properties. [Also see Perspective by Schwefel] Authors: B. Peng, Ş. K. Özdemir, S. Rotter, H. Yilmaz, M. Liertzer, F. Monifi, C. M. Bender, F. Nori, L. Yang
 2014-10-17 [Report] Cavity quantum electrodynamics with many-body states of a two-dimensional electron gas
Optics may provide insight into the complex many-body interactions of a two-dimensional electron gas. Authors: Stephan Smolka, Wolf Wuester, Florian Haupt, Stefan Faelt, Werner Wegscheider, Ataç Imamoglu
 2014-10-17 [Report] Ultrafast electron dynamics in phenylalanine initiated by attosecond pulses
Electronic dynamics in a complex polyatomic molecule are tracked faster than the time scale for vibrational motion. Authors: F. Calegari, D. Ayuso, A. Trabattoni, L. Belshaw, S. De Camillis, S. Anumula, F. Frassetto, L. Poletto, A. Palacios, P. Decleva, J. B. Greenwood, F. Martín, M. Nisoli
 2014-10-17 [Report] Neural correlates of strategic reasoning during competitive games
Neuronal responses in the dorsomedial prefrontal cortex predict choices and switches in gaming strategies in monkeys. Authors: Hyojung Seo, Xinying Cai, Christopher H. Donahue, Daeyeol Lee
 2014-10-17 [Report] Perception of root-derived peptides by shoot LRR-RKs mediates systemic N-demand signaling
Nitrogen-starved rootlets send small peptides to the shoot to initiate compensatory uptake in other rootlets. [Also see Perspective by Bisseling and Scheres] Authors: Ryo Tabata, Kumiko Sumida, Tomoaki Yoshii, Kentaro Ohyama, Hidefumi Shinohara, Yoshikatsu Matsubayashi
 2014-10-17 [Report] Large carnivores make savanna tree communities less thorny
Changes to thorny plant defenses and high predator risk for impala determine density and distribution of savanna trees. Authors: Adam T. Ford, Jacob R. Goheen, Tobias O. Otieno, Laura Bidner, Lynne A. Isbell, Todd M. Palmer, David Ward, Rosie Woodroffe, Robert M. Pringle
 2014-10-17 [Report] Increased variability of tornado occurrence in the United States
Tornadoes have been occurring in a more clustered fashion since the 1970s. Authors: Harold E. Brooks, Gregory W. Carbin, Patrick T. Marsh
 2014-10-17 [Report] Ion permeation in K+ channels occurs by direct Coulomb knock-on
Simulation shows that ions crossing a potassium channel are in direct contact with one another and repel each other through. [Also see Perspective by Hummer] Authors: David A. Köpfer, Chen Song, Tim Gruene, George M. Sheldrick, Ulrich Zachariae, Bert L. de Groot
 2014-10-17 [Report] Structure and selectivity in bestrophin ion channels
A bacterial homolog structure gives insights into ion permeation, gating, and mutations that cause retinal degeneration. Authors: Tingting Yang, Qun Liu, Brian Kloss, Renato Bruni, Ravi C. Kalathur, Youzhong Guo, Edda Kloppmann, Burkhard Rost, Henry M. Colecraft, Wayne A. Hendrickson
 2014-10-17 [Report] HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span
A transcription factor may promote longevity by stabilizing the actin cytoskeleton in nematodes. Authors: Nathan A. Baird, Peter M. Douglas, Milos S. Simic, Ana R. Grant, James J. Moresco, Suzanne C. Wolff, John R. Yates, Gerard Manning, Andrew Dillin
 2014-10-17 [Report] Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
In a mouse model of rheumatoid arthritis, autoimmune T cells recognize a protein from the ribosome. Authors: Yoshinaga Ito, Motomu Hashimoto, Keiji Hirota, Naganari Ohkura, Hiromasa Morikawa, Hiroyoshi Nishikawa, Atsushi Tanaka, Moritoshi Furu, Hiromu Ito, Takao Fujii, Takashi Nomura, Sayuri Yamazaki, Akimichi Morita, Dario A. A. Vignali, John W. Kappler, Shuichi Matsuda, Tsuneyo Mimori, Noriko Sakaguchi, Shimon Sakaguchi
 2014-10-17 [New Products] New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
 2014-10-17 [Podcast] Science Podcast: 17 October Show
On this week's show: Connecting carnivores with plants and a daily news roundup.
 2014-10-17 [Business Office Feature] Part 1: Targeting cancer pathways: Tumor resistance
Michael B. Yaffe
 2014-10-17 [Business Office Feature] Employees thrive on innovative design
Virginia Gewin
 2014-10-17 [Working Life] Life inspires applications
Author: Sharon Ann Holgate

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