webTB.org  Home  Login/out  Consortium Info  Feedback  

News/Articles Feeds from BMC, Nature, Science


Back to TB Home

Deprecated: Function set_magic_quotes_runtime() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/zfeeder.php on line 60

Deprecated: Function split() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/zfeeder.php on line 92

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305
BMC Structural Biology - Latest Articles   [more] [xml]
 2014-09-23T00:00:00Z Buried chloride stereochemistry in the Protein Data Bank
Background: Despite the chloride anion is involved in fundamental biological processes, its interactions with proteins are little known. In particular, we lack a systematic survey of its coordination spheres. Results: The analysis of a non-redundant set (pairwise sequence identity < 30%) of 1739 high resolution (<2 Å) crystal structures that contain at least one chloride anion shows that the first coordination spheres of the chlorides are essentially constituted by hydrogen bond donors. Amongst the side-chains positively charged, arginine interacts with chlorides much more frequently than lysine. Although the most common coordination number is 4, the coordination stereochemistry is closer to the expected geometry when the coordination number is 5, suggesting that this is the coordination number towards which the chlorides tend when they interact with proteins. Conclusions: The results of these analyses are useful in interpreting, describing, and validating new protein crystal structures that contain chloride anions.


Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305
BMC Bioinformatics - Latest Articles   [more] [xml]
 2014-09-30T00:00:00Z MAE-FMD: Multi-agent evolutionary method for functional module detection in protein-protein interaction networks
Background: Studies of functional modules in a Protein-Protein Interaction (PPI) network contribute greatly to theunderstanding of biological mechanisms. With the development of computing science,computational approaches have played an important role in detecting functional modules. Results: We present a new approach using multi-agent evolution for detection of functional modules in PPInetworks. The proposed approach consists of two stages: the solution construction for agents in apopulation and the evolutionary process of computational agents in a lattice environment, where eachagent corresponds to a candidate solution to the detection problem of functional modules in a PPInetwork. First, the approach utilizes a connection-based encoding scheme to model an agent, andemploys a random-walk behavior merged topological characteristics with functional information toconstruct a solution. Next, it applies several evolutionary operators, i. e., competition, crossover, andmutation, to realize information exchange among agents as well as solution evolution. Systematicexperiments have been conducted on three benchmark testing sets of yeast networks. Experimentalresults show that the approach is more effective compared to several other existing algorithms. Conclusions: The algorithm has the characteristics of outstanding recall, F-measure, sensitivity and accuracy whilekeeping other competitive performances, so it can be applied to the biological study which requireshigh accuracy.


Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305
BMC Genomics - Latest Articles   [more] [xml]
 2014-10-01T00:00:00Z Population history and genomic signatures for high-altitude adaptation in Tibetan pigs
Background: The Tibetan pig is one of domestic animals indigenous to the Qinghai-Tibet Plateau. Several geographically isolated pig populations are distributed throughout the Plateau. It remained an open question if these populations have experienced different demographic histories and have evolved independent adaptive loci for the harsh environment of the Plateau. To address these questions, we herein investigated ~ 40,000 genetic variants across the pig genome in a broad panel of 678 individuals from 5 Tibetan geographic populations and 34 lowland breeds. Results: Using a series of population genetic analyses, we show that Tibetan pig populations have marked genetic differentiations. Tibetan pigs appear to be 3 independent populations corresponding to the Tibetan, Gansu and Sichuan & Yunnan locations. Each population is more genetically similar to its geographic neighbors than to any of the other Tibetan populations. By applying a locus-specific branch length test, we identified both population-specific and -shared candidate genes under selection in Tibetan pigs. These genes, such as PLA2G12A, RGCC, C9ORF3, GRIN2B, GRID1 and EPAS1, are involved in high-altitude physiology including angiogenesis, pulmonary hypertension, oxygen intake, defense response and erythropoiesis. A majority of these genes have not been implicated in previous studies of highlanders and high-altitude animals. Conclusion: Tibetan pig populations have experienced substantial genetic differentiation. Historically, Tibetan pigs likely had admixture with neighboring lowland breeds. During the long history of colonization in the Plateau, Tibetan pigs have developed a complex biological adaptation mechanism that could be different from that of Tibetans and other animals. Different Tibetan pig populations appear to have both distinct and convergent adaptive loci for the harsh environment of the Plateau.


Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305
BMC Biochemistry - Latest Articles   [more] [xml]
 2014-09-10T00:00:00Z Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B
Background: Previous screening of the substrate repertoires and substrate specificity profiles of granzymes resulted in long substrate lists highly likely containing bystander substrates. Here, a recently developed degradomics technology that allows distinguishing efficiently from less efficiently cleaved substrates was applied to study the degradome of mouse granzyme B (mGrB). Results: In vitro kinetic degradome analysis resulted in the identification of 37 mGrB cleavage events, 9 of which could be assigned as efficiently targeted ones. Previously, cleavage at the IEAD75 tetrapeptide motif of Bid was shown to be efficiently and exclusively targeted by human granzyme B (hGrB) and thus not by mGrB. Strikingly, and despite holding an identical P4-P1 human Bid (hBid) cleavage motif, mGrB was shown to efficiently cleave the BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 or BNIP-2 at IEAD28. Like Bid, BNIP-2 represents a pro-apoptotic Bcl-2 protein family member and a potential regulator of GrB induced cell death. Next, in vitro analyses demonstrated the increased efficiency of human and mouse BNIP-2 cleavage by mGrB as compared to hGrB indicative for differing Bid/BNIP-2 substrate traits beyond the P4-P1 IEAD cleavage motif influencing cleavage efficiency. Murinisation of differential primed site residues in hBNIP-2 revealed that, although all contributing, a single mutation at the P3′ position was found to significantly increase the mGrB/hGrB cleavage ratio, whereas mutating the P1′ position from I29 > T yielded a 4-fold increase in mGrB cleavage efficiency. Finally, mutagenesis analyses revealed the composite BNIP-2 precursor patterns to be the result of alternative translation initiation at near-cognate start sites within the 5′ leader sequence (5′UTR) of BNIP-2. Conclusions: Despite their high sequence similarity, and previously explained by their distinct tetrapeptide specificities observed, the substrate repertoires of mouse and human granzymes B only partially overlap. Here, we show that the substrate sequence context beyond the P4-P1 positions can influence orthologous granzyme B cleavage efficiencies to an unmatched extent. More specifically, in BNIP-2, the identical and hGrB optimal IEAD tetrapeptide substrate motif is targeted highly efficiently by mGrB, while this tetrapeptide motif is refractory towards mGrB cleavage in Bid.


Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305
Nature   [more] [xml]
 2005-01-19 Einstein is dead
Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.

Einstein is dead

Nature 433, 179 (2005). doi:10.1038/433179a

Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.



Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305

Deprecated: Function ereg_replace() is deprecated in /var/www/html/TB2/PUBLIC/RSS/newsfeeds/includes/zfuncs.php on line 305
Science: Current Issue   [more] [xml]
 2014-09-26 [Editorial] The drought you can't see
The Western Hemisphere is experiencing a drought of crisis proportions. In Central America, crops are failing, millions are in danger of starvation, and if the drought doesn't break soon, even vessels transiting the Panama Canal will need to lighten their loads, which will increase prices for goods transported globally. In the western United States, the drought-stricken region spans a vast area responsible for much of the nation's fruits, vegetables, and beef. As the drought's grip has tightened, water users have turned to tapping groundwater aquifers to make up the deficit for people, crops, livestock, and industry. But even when the rain does return, regreening the landscape and filling again the streams, lakes, and reservoirs, those aquifers will remain severely depleted. It is this underground drought we can't see that is enduring, worrisome, and in need of attention. Author: Marcia McNutt
 2014-09-26 [In Brief] This week's section
A roundup of weekly science policy and related news.
 2014-09-26 [In Depth] Evidence for cosmic inflation wanes
The biggest result in cosmology in a decade fades into dust. Author: Adrian Cho
 2014-09-26 [In Depth] Red wolves in the crosshairs
U.S. agency ponders future of innovative reintroduction as animal deaths and controversy mount. Author: Erik Stokstad
 2014-09-26 [In Depth] Testing new Ebola tests
Identifying infections more quickly and easily could help slow the epidemic. Author: Gretchen Vogel
 2014-09-26 [In Depth] Metabolic shift may train immune cells
BLUEPRINT project studies epigenetics of various blood cells. Author: Elizabeth Pennisi
 2014-09-26 [Feature] On the edge
Ecologist Marten Scheffer became a leader in the science of tipping points by studying lakes. Now he's making waves in many other fields. Author: Gabriel Popkin
 2014-09-26 [Feature] NOνA's shining moment
Despite years of delay, Fermilab's massive new experiment has a chance to take the next big step in neutrino physics. Author: Adrian Cho
 2014-09-26 [Perspective] Whose conservation?
Changes in the perception and goals of nature conservation require a solid scientific basis Author: Georgina M. Mace
 2014-09-26 [Perspective] Autoimmunity by haploinsufficiency
Partial deficiency in the protein CTLA4 underlies severe autoimmune disease with incomplete penetrance [Also see Report by Kuehn et al.] Authors: Frédéric Rieux-Laucat, Jean-Laurent Casanova
 2014-09-26 [Policy Forum] Implementing Pasteur's vision for rabies elimination
Human and veterinary health systems must be better integrated if rabies is to be controlled Authors: Felix Lankester, Katie Hampson, Tiziana Lembo, Guy Palmer, Louise Taylor, Sarah Cleaveland
 2014-09-26 [Perspective] Water's place in Au catalysis
Water plays a key role in gold-catalyzed CO oxidation [Also see Report by Saavedra et al.] Authors: Gregory M. Mullen, C. Buddie Mullins
 2014-09-26 [Perspective] Managing patterns and proportions over time
Tissue patterning is specified relative to growth through differences between cell proliferation and the differentiation rates [Also see Research Article by Kicheva et al.] Author: Olivier Pourquie
 2014-09-26 [Perspective] Perovskites take lead in solar hydrogen race
Earth-abundant materials show promise for solar hydrogen production [Also see Report by Luo et al.] Author: Thomas Hamann
 2014-09-26 [Perspective] A dynamic tool for nitrogen reduction
Carbon monoxide reveals new possibilities for substrate binding in nitrogenase [Also see Report by Spatzal et al.] Author: Martin Högbom
 2014-09-26 [Book Review] Feeling your pain
Author: Warwick Anderson
 2014-09-26 [Books et al.] Books Received
A listing of books received at Science during the week ending 19 September 2014.
 2014-09-26 [Letter] Brazil's new laws bug collectors
Authors: Danilo Bandini Ribeiro, André Victor Lucci Freitas
 2014-09-26 [Letter] Parenting: Section deserves a scolding
Author: Jean Mercer
 2014-09-26 [Letter] Parenting: Roots of the sweet tooth
Authors: André Krumel Portella, Patrícia Pelufo Silveira
 2014-09-26 [Association Affairs] AAAS news and notes
A monthly roundup of recent news and projects of Science's publisher, the American Association for the Advancement of Science.
 2014-09-26 This Week in Science
A complex network makes simple pores | Crustal rebound from water drawdown | Mysterious dinosaur a swimmer? | Easier oxidation over gold with added water | Beware of T cells that don't know how to stop | Closing the loop on neuroprosthetic control | Hot electron plasma moves in from Io | Preventing vascular scarring after surgery | Differentiation rates regulate pool sizes | Carbon chains branch out on space dust | Nature or nurture for solar system ices? | A BLUEPRINT of immune cell development | Making nitrogen available for biosynthesis | The power of a pair of perovskites | Breaking down a Criegee intermediate | An early assemblage of obsidian artifacts | How plant species diversity is shaped | Animal behavior follows rewards | Views of nature, views of conservation
 2014-09-26 Editors' Choice
Timing counts for whisker development | Animal behavior follows dopamine rewards | Bring out your dead — hungry receptors await | An Arabian wintertime bloom on the rise | Hate and violence spread through the air | Social complexity creates brainy parrots | Teaching tolerance stops the bleeding | Constructing a maze full of phosphines
 2014-09-26 [Research Article] Coordination of progenitor specification and growth in mouse and chick spinal cord
Embryonic chick and mouse reveal how neural tube differentiation takes on new strategies as development progresses. [Also see Perspective by Pourquie] Authors: Anna Kicheva, Tobias Bollenbach, Ana Ribeiro, Helena Pérez Valle, Robin Lovell-Badge, Vasso Episkopou, James Briscoe
 2014-09-26 [Research Article] Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Genome-wide approaches analyze human monocyte differentiation in vitro into functional macrophages. Authors: Sadia Saeed, Jessica Quintin, Hindrik H. D. Kerstens, Nagesha A. Rao, Ali Aghajanirefah, Filomena Matarese, Shih-Chin Cheng, Jacqueline Ratter, Kim Berentsen, Martijn A. van der Ent, Nilofar Sharifi, Eva M. Janssen-Megens, Menno Ter Huurne, Amit Mandoli, Tom van Schaik, Aylwin Ng, Frances Burden, Kate Downes, Mattia Frontini, Vinod Kumar, Evangelos J. Giamarellos-Bourboulis, Willem H. Ouwehand, Jos W. M. van der Meer, Leo A. B. Joosten, Cisca Wijmenga, Joost H. A. Martens, Ramnik J. Xavier, Colin Logie, Mihai G. Netea, Hendrik G. Stunnenberg
 2014-09-26 [Research Article] mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Epigenetic profiling identifies the cellular metabolic substrate of innate immune memory. Authors: Shih-Chin Cheng, Jessica Quintin, Robert A. Cramer, Kelly M. Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J. Giamarellos-Bourboulis, Joost H. A. Martens, Nagesha Appukudige Rao, Ali Aghajanirefah, Ganesh R. Manjeri, Yang Li, Daniela C. Ifrim, Rob J. W. Arts, Brian M. J. W. van der Meer, Peter M. T. Deen, Colin Logie, Luke A. O’Neill, Peter Willems, Frank L. van de Veerdonk, Jos W. M. van der Meer, Aylwin Ng, Leo A. B. Joosten, Cisca Wijmenga, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea
 2014-09-26 [Research Article] Transcriptional diversity during lineage commitment of human blood progenitors
RNA sequencing identifies how different cell fate decisions are made during blood cell differentiation. Authors: Lu Chen, Myrto Kostadima, Joost H. A. Martens, Giovanni Canu, Sara P. Garcia, Ernest Turro, Kate Downes, Iain C. Macaulay, Ewa Bielczyk-Maczynska, Sophia Coe, Samantha Farrow, Pawan Poudel, Frances Burden, Sjoert B. G. Jansen, William J. Astle, Antony Attwood, Tadbir Bariana, Bernard de Bono, Alessandra Breschi, John C. Chambers, , Fizzah A. Choudry, Laura Clarke, Paul Coupland, Martijn van der Ent, Wendy N. Erber, Joop H. Jansen, Rémi Favier, Matthew E. Fenech, Nicola Foad, Kathleen Freson, Chris van Geet, Keith Gomez, Roderic Guigo, Daniel Hampshire, Anne M. Kelly, Hindrik H. D. Kerstens, Jaspal S. Kooner, Michael Laffan, Claire Lentaigne, Charlotte Labalette, Tiphaine Martin, Stuart Meacham, Andrew Mumford, Sylvia Nürnberg, Emilio Palumbo, Bert A. van der Reijden, David Richardson, Stephen J. Sammut, Greg Slodkowicz, Asif U. Tamuri, Louella Vasquez, Katrin Voss, Stephen Watt, Sarah Westbury, Paul Flicek, Remco Loos, Nick Goldman, Paul Bertone, Randy J. Read, Sylvia Richardson, Ana Cvejic, Nicole Soranzo, Willem H. Ouwehand, Hendrik G. Stunnenberg, Mattia Frontini, Augusto Rendon
 2014-09-26 [Report] Evidence for global electron transportation into the jovian inner magnetosphere
Near-Earth satellite measurements in the extreme ultraviolet examine a charged torus produced by volcanoes on Jupiter’s moon Io. Authors: K. Yoshioka, G. Murakami, A. Yamazaki, F. Tsuchiya, T. Kimura, M. Kagitani, T. Sakanoi, K. Uemizu, Y. Kasaba, I. Yoshikawa, M. Fujimoto
 2014-09-26 [Report] Detection of a branched alkyl molecule in the interstellar medium: iso-propyl cyanide
Millimeter-wave emission is detected from branched carbon-chain molecules that may form on interstellar dust-grain surfaces. Authors: Arnaud Belloche, Robin T. Garrod, Holger S. P. Müller, Karl M. Menten
 2014-09-26 [Report] Ongoing drought-induced uplift in the western United States
GPS measurements of crustal rebound in the western U.S. quantify drought-induced regional water depletion. Authors: Adrian Antal Borsa, Duncan Carr Agnew, Daniel R. Cayan
 2014-09-26 [Report] The ancient heritage of water ice in the solar system
A model tracing the path of deuterium in the solar system shows that its abundance hails from the parent interstellar medium. Authors: L. Ilsedore Cleeves, Edwin A. Bergin, Conel M. O’D. Alexander, Fujun Du, Dawn Graninger, Karin I. Öberg, Tim J. Harries
 2014-09-26 [Report] Water photolysis at 12.3% efficiency via perovskite photovoltaics and Earth-abundant catalysts
A pair of perovskite solar cells can power efficient hydrogen generation from water. [Also see Perspective by Hamann] Authors: Jingshan Luo, Jeong-Hyeok Im, Matthew T. Mayer, Marcel Schreier, Mohammad Khaja Nazeeruddin, Nam-Gyu Park, S. David Tilley, Hong Jin Fan, Michael Grätzel
 2014-09-26 [Report] Infrared-driven unimolecular reaction of CH3CHOO Criegee intermediates to OH radical products
Spectroscopy in the laboratory elucidates key steps in ozone’s atmospheric reaction with unsaturated hydrocarbons. Authors: Fang Liu, Joseph M. Beames, Andrew S. Petit, Anne B. McCoy, Marsha I. Lester
 2014-09-26 [Report] The critical role of water at the gold-titania interface in catalytic CO oxidation
Adsorbed water enables proton-transfer steps that lower the activation barrier for carbon monoxide oxidation. [Also see Perspective by Mullen and Mullins] Authors: Johnny Saavedra, Hieu A. Doan, Christopher J. Pursell, Lars C. Grabow, Bert D. Chandler
 2014-09-26 [Report] Environmental filtering explains variation in plant diversity along resource gradients
A >2-million-year soil chronosequence reveals how the environment can regulate species plant diversity. Authors: Etienne Laliberté, Graham Zemunik, Benjamin L. Turner
 2014-09-26 [Report] Direct roles of SPEECHLESS in the specification of stomatal self-renewing cells
The molecular pathways that regulate an essential adult stem cell lineage in plant stomata are dissected. Authors: On Sun Lau, Kelli A. Davies, Jessica Chang, Jessika Adrian, Matthew H. Rowe, Catherine E. Ballenger, Dominique C. Bergmann
 2014-09-26 [Report] Early Levallois technology and the Lower to Middle Paleolithic transition in the Southern Caucasus
An assemblage of obsidian artifacts suggests independent origins of stone knapping in different hominin populations. Authors: D. S. Adler, K. N. Wilkinson, S. Blockley, D. F. Mark, R. Pinhasi, B. A. Schmidt-Magee, S. Nahapetyan, C. Mallol, F. Berna, P. J. Glauberman, Y. Raczynski-Henk, N. Wales, E. Frahm, O. Jöris, A. MacLeod, V. C. Smith, V. L. Cullen, B. Gasparian
 2014-09-26 [Report] Semiaquatic adaptations in a giant predatory dinosaur
New fossils of the sail-finned predatory dinosaur Spinosaurus reveal that it lived in and near water. Authors: Nizar Ibrahim, Paul C. Sereno, Cristiano Dal Sasso, Simone Maganuco, Matteo Fabbri, David M. Martill, Samir Zouhri, Nathan Myhrvold, Dawid A. Iurino
 2014-09-26 [Report] A critical time window for dopamine actions on the structural plasticity of dendritic spines
Dopamine promotes spine structural plasticity during a narrow time window in mouse neuron distal dendrites. Authors: Sho Yagishita, Akiko Hayashi-Takagi, Graham C.R. Ellis-Davies, Hidetoshi Urakubo, Shin Ishii, Haruo Kasai
 2014-09-26 [Report] Ligand binding to the FeMo-cofactor: Structures of CO-bound and reactivated nitrogenase
The structure of an inhibitor bound to nitrogenase reveals rearrangements in the active-site metallocluster. [Also see Perspective by Hognom] Authors: Thomas Spatzal, Kathryn A. Perez, Oliver Einsle, James B. Howard, Douglas C. Rees
 2014-09-26 [Report] Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
A mutation in a single copy of the CTLA4 gene in people is associated with immune dysfunction. [Also see Perspective by Rieux-Laucat and Casanova] Authors: Hye Sun Kuehn, Weiming Ouyang, Bernice Lo, Elissa K. Deenick, Julie E. Niemela, Danielle T. Avery, Jean-Nicolas Schickel, Dat Q. Tran, Jennifer Stoddard, Yu Zhang, David M. Frucht, Bogdan Dumitriu, Phillip Scheinberg, Les R. Folio, Cathleen A. Frein, Susan Price, Christopher Koh, Theo Heller, Christine M. Seroogy, Anna Huttenlocher, V. Koneti Rao, Helen C. Su, David Kleiner, Luigi D. Notarangelo, Yajesh Rampertaap, Kenneth N. Olivier, Joshua McElwee, Jason Hughes, Stefania Pittaluga, Joao B. Oliveira, Eric Meffre, Thomas A. Fleisher, Steven M. Holland, Michael J. Lenardo, Stuart G. Tangye, Gulbu Uzel
 2014-09-26 [Association Affairs] Gordon Research Conferences
This issue of Science includes the program of the 2015 AAAS Annual Meeting. 2015 “Session I” Meetings will be held between January and May in California and Texas in the United States, and internationally in Lucca (Barga), Italy and Hong Kong, China. A PDF of the program as it appears in this issue is available here; for more information on the meeting (including registration forms and information on accommodations), please visit www.grc.org.
 2014-09-26 [New Products] New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
 2014-09-26 [Podcast] Science Podcast: 26 September Show
On this week's show: Tracing the roots of an ancient stone-age technology and a daily news round up with David Grimm.
 2014-09-26 [Business Office Feature] Culturing human cells: Optimizing growth conditions for immunotherapy
Laurence J. N. Cooper
 2014-09-26 [Business Office Feature] CRISPR-Cas9: Engineering a revolution in gene editing
The CRISPR-Cas9 system is revolutionizing genomic engineering and equipping scientists with the ability to precisely modify the DNA of essentially any organism. Just how powerful is this technique? The ability for precision genome engineering comes with the potential to enhance food production, medicinal discoveries, and energy solutions, to name a few. In this booklet, we invite you to explore a selection of Science articles that highlight how this technique has grown into one of the most powerful genomic engineering tools to date. CRISPR-Cas9 (PDF, 14.6 MB)CRISPR-Cas9 (PDF, low resolution version, 3.16 MB)Read the e-bookletThis booklet brought to you by the Science/AAAS Custom Publishing Office.DOI: 10.1126/science.opms.sb0002
 2014-09-26 [Working Life] The borders I crossed
Author: Rodica Stan

powered by zFeeder