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BMC Structural Biology - Latest Articles   [more] [xml]
 2014-10-18T00:00:00Z A PDB-wide, evolution-based assessment of protein¿protein interfaces
Background: Thanks to the growth in sequence and structure databases, more than 50 million sequences are now available in UniProt and 100,000 structures in the PDB. Rich information about protein?protein interfaces can be obtained by a comprehensive study of protein contacts in the PDB, their sequence conservation and geometric features. Results: An automated computational pipeline was developed to run our Evolutionary Protein?Protein Interface Classifier (EPPIC) software on the entire PDB and store the results in a relational database, currently containing > 800,000 interfaces. This allows the analysis of interface data on a PDB-wide scale. Two large benchmark datasets of biological interfaces and crystal contacts, each containing about 3000 entries, were automatically generated based on criteria thought to be strong indicators of interface type. The BioMany set of biological interfaces includes NMR dimers solved as crystal structures and interfaces that are preserved across diverse crystal forms, as catalogued by the Protein Common Interface Database (ProtCID) from Xu and Dunbrack. The second dataset, XtalMany, is derived from interfaces that would lead to infinite assemblies and are therefore crystal contacts. BioMany and XtalMany were used to benchmark the EPPIC approach. The performance of EPPIC was also compared to classifications from the Protein Interfaces, Surfaces, and Assemblies (PISA) program on a PDB-wide scale, finding that the two approaches give the same call in about 85% of PDB interfaces. By comparing our safest predictions to the PDB author annotations, we provide a lower-bound estimate of the error rate of biological unit annotations in the PDB. Additionally, we developed a PyMOL plugin for direct download and easy visualization of EPPIC interfaces for any PDB entry. Both the datasets and the PyMOL plugin are available at http://www.eppic-web.org/ewui/\#downloads. Conclusions: Our computational pipeline allows us to analyze protein?protein contacts and their sequence conservation across the entire PDB. Two new benchmark datasets are provided, which are over an order of magnitude larger than existing manually curated ones. These tools enable the comprehensive study of several aspects of protein?protein contacts in the PDB and represent a basis for future, even larger scale studies of protein?protein interactions.


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BMC Bioinformatics - Latest Articles   [more] [xml]
 2014-10-31T00:00:00Z CIG-P: Cicular Interaction Graph for Proteomics
Background: A typical affinity purification coupled to mass spectrometry (AP-MS) experiment includes the purification of a target protein (bait) using an antibody and subsequent mass spectrometry analysis of all proteins co-purifying with the bait (aka prey proteins). Like any other systems biology approach, AP-MS experiments generate a lot of data and visualization has been challenging, especially when integrating AP-MS experiments with orthogonal datasets. Results: We present Circular Interaction Graph for Proteomics (CIG-P), which generates circular diagrams for visually appealing final representation of AP-MS data. Through a Java based GUI, the user inputs experimental and reference data as file in csv format. The resulting circular representation can be manipulated live within the GUI before exporting the diagram as vector graphic in pdf format. The strength of CIG-P is the ability to integrate orthogonal datasets with each other, e.g. affinity purification data of kinase PRPF4B in relation to the functional components of the spliceosome. Further, various AP-MS experiments can be compared to each other. Conclusions: CIG-P aids to present AP-MS data to a wider audience and we envision that the tool finds other applications too, e.g. kinase - substrate relationships as a function of perturbation. CIG-P is available under: http://sourceforge.net/projects/cig-p/


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BMC Genomics - Latest Articles   [more] [xml]
 2014-10-31T00:00:00Z Omics technologies provide new insights into the molecular physiopathology of equine osteochondrosis
Background: Osteochondrosis (OC(D)) is a juvenile osteo-articular disorder affecting several mammalian species. In horses, OC(D) is considered as a multifactorial disease and has been described as a focal disruption of endochondral ossification leading to the development of osteoarticular lesions. Nevertheless, OC(D) physiopathology is poorly understood. Affected horses may present joint swelling, stiffness and lameness. Thus, OC(D) is a major concern for the equine industry. Our study was designed as an integrative approach using omics technologies for the identification of constitutive defects in epiphyseal cartilage and/or subchondral bone associated with the development of primary lesions to further understand OC(D) pathology. This study compared samples from non-affected joints (hence lesion-free) from OC(D)-affected foals (n = 5, considered predisposed samples) with samples from OC-free foals (n = 5) considered as control samples. Consequently, results are not confounded by changes associated with the evolution of the lesion, but focus on altered constitutive molecular mechanisms. Comparative proteomics and micro computed tomography analyses were performed on predisposed and OC-free bone and cartilage samples. Metabolomics was also performed on synovial fluid from OC-free, OC(D)-affected and predisposed joints. Results: Two lesion subtypes were identified: OCD (lesion with fragment) and OC (osteochondral defects). Modulated proteins were identified using omics technologies (metabolomics and proteomics) in cartilage and bone from affected foals compare to OC-free foals. These were associated with cellular processes including cell cycle, energy production, cell signaling and adhesion as well as tissue-specific processes such as chondrocyte maturation, extracellular matrix and mineral metabolism. Of these, five had already been identified in synovial fluid of OC-affected foals: ACTG1 (actin, gamma 1), albumin, haptoglobin, FBG (fibrinogen beta chain) and C4BPA (complement component 4 binding protein, alpha). Conclusion: This study suggests that OCD lesions may result from a cartilage defect whereas OC lesions may be triggered by both bone and cartilage defects, suggesting that different molecular mechanisms responsible for the equine osteochondrosis lesion subtypes and predisposition could be due to a defect in both bone and cartilage. This study will contribute to refining the definition of OC(D) lesions and may improve diagnosis and development of therapies for horses and other species, including humans.


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BMC Biochemistry - Latest Articles   [more] [xml]
 2014-10-09T00:00:00Z Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with l-tyrosine and l-DOPA
Background: Hydroxyl radical that has the highest reactivity among reactive oxygen species (ROS) is generated through l-tyrosine-tyrosinase reaction. Thus, the melanogenesis might induce oxidative stress in the skin. Arbutin (p-hydroxyphenyl-β-d-glucopyranoside), a well-known tyrosinase inhibitor has been widely used for the purpose of skin whitening. The aim of the present study was to examine if arbutin could suppress the hydroxyl radical generation via tyrosinase reaction with its substrates, l-tyrosine and l-DOPA. Results: The hydroxyl radical, which was determined by an electron spin resonance-spin trapping technique, was generated by the addition of not only l-tyrosine but l-DOPA to tyrosinase in a concentration dependent manner. Arbutin could inhibit the hydroxyl radical generation in the both reactions. Conclusion: It is presumed that arbutin could alleviate oxidative stress derived from the melanogenic pathway in the skin in addition to its function as a whitening agent in cosmetics.


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Nature   [more] [xml]
 2005-01-19 Einstein is dead
Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.

Einstein is dead

Nature 433, 179 (2005). doi:10.1038/433179a

Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.



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Science: Current Issue   [more] [xml]
 2014-10-31 [Editorial] Planet at the crossroads
When we think of nature in 2014, chances are that protected areas come to mind: Amazonian rainforests teeming with wildlife, the sweeping plains of the Serengeti, or an Alpine lake surrounded by glaciers. But the world's protected areas are at a crossroads, and next month, when the International Union for Conservation of Nature (IUCN) convenes its once-in-a-decade World Parks Congress in Sydney, Australia, nations will discuss how to address the challenges in protecting ecosystems across the world for the benefit of humanity. Author: Julia Marton-Lefèvre
 2014-10-31 [In Brief] This week's section
A roundup of weekly science policy and related news.
 2014-10-31 [In Depth] The coming salamander plague
Already harming a European species, an Asian fungus could wreak havoc in North America. Author: Erik Stokstad
 2014-10-31 [In Depth] An easy consciousness test?
EEG studies detect awareness in locked-in people. Author: Emily Underwood
 2014-10-31 [In Depth] Modern symbionts inside cells mimic organelle evolution
Long-term partnerships can result in extremes in genome reduction or expansion. Author: Elizabeth Pennisi
 2014-10-31 [In Depth] The Ebola vaccine underdog
NewLink Genetics says it might have enough doses ready by spring to vaccinate most people at risk. Author: Jon Cohen
 2014-10-31 [In Depth] Friends, not foes, boost warriors' success
New analysis of Yanomamö data suggests that alliances among in-laws raise fighters' fitness. Author: Lizzie Wade
 2014-10-31 [In Depth] Low oxygen stifled animals' emergence, study says
Rocks shed light on a billion years of stalled evolution. Author: Carolyn Gramling
 2014-10-31 [Feature] Stepping on the gas
What would it take to put you behind the wheel of a methane-powered vehicle? Researchers are determined to find out. Author: Robert F. Service
 2014-10-31 [Perspective] Complete pairing not needed
Structures of microRNA-mRNA–human Argonaute reveal where and how intermolecular interactions are specified [Also see Research Article by Schirle et al.] Author: Dinshaw J. Patel
 2014-10-31 [Perspective] Clarifying the structure of carbonic acid
Discrepancies in the reported structures of the difficult-to-isolate solid form of a common acid have been resolved Authors: Götz Bucher, Wolfram Sander
 2014-10-31 [Perspective] Seeking out Majorana under the microscope
A chain of iron atoms on lead may reveal a signature of the elusive Majorana particle [Also see Research Article by Nadj-Perge et al.] Author: Patrick A. Lee
 2014-10-31 [Policy Forum] Adolescent mental health—Opportunity and obligation
Emerging neuroscience offers hope for treatments Authors: Francis S. Lee, Hakon Heimer, Jay N. Giedd, Edward S Lein, Nenad Šestan, Daniel R. Weinberger, B. J. Casey
 2014-10-31 [Perspective] The value of valuing nature
Valuing nature in economic terms is not always beneficial for biodiversity conservation Author: W. M. Adams
 2014-10-31 [Perspective] The atoms of neural computation
Does the brain depend on a set of elementary, reusable computations? Authors: Gary Marcus, Adam Marblestone, Thomas Dean
 2014-10-31 [Essay] Shortcuts and checkpoints on the road to skilled movement
Coordinating intricate motor circuits Author: Eiman Azim
 2014-10-31 [Essay] Jump-starting natural resilience reverses stress susceptibility
Novel therapy for treating depression Author: Allyson Friedman
 2014-10-31 [Essay] Functional organization of synaptic connections in the neocortex
Neural networks and computation Author: Ho Ko
 2014-10-31 [Book Review] Braaaains
Author: Steven C. Schlozman
 2014-10-31 [Book Review] Advantage: Science
Author: Pamela J. Hines
 2014-10-31 [Books et al.] Books Received
A listing of books received at Science during the week ending 24 October 2014.
 2014-10-31 [Letter] Venezuelan science in dire straits
Authors: Alberto E. Paniz-Mondolfi, Alfonso J. Rodríguez-Morales
 2014-10-31 [Letter] Population growth: Peak probability
Authors: Wolfgang Lutz, William Butz, Samir KC, Warren Sanderson, Sergei Scherbov
 2014-10-31 [Letter] Population growth: Limits of food supply
Author: Robert R. Holt
 2014-10-31 [Technical Comment] Comment on “Control profiles of complex networks”
Ruths and Ruths (Reports, 21 March 2014, p. 1373) find that existing synthetic random network models fail to generate control profiles that match those found in real network models. Here, we show that a straightforward extension to the Barabási-Albert model allows the control profile to be “tuned” across the control profile space, permitting more meaningful control profile analyses of real networks. Authors: Colin Campbell, Katriona Shea, Réka Albert
 2014-10-31 [Technical Response] Response to Comment on “Control profiles of complex networks”
Campbell, Shea, and Albert propose an adaptation of the Barabási-Albert model of network formation that permits a level of tuning of the control profiles of these networks. We point out some limitations and generalizations of this method as well as highlight opportunities for future work to refine formation mechanisms to provide control profile tuning in synthetic networks. Authors: Justin Ruths, Derek Ruths
 2014-10-31 [Association Affairs] AAAS news and notes
A monthly roundup of recent news and projects of Science's publisher, the American Association for the Advancement of Science.
 2014-10-31 [Introduction to Special Issue] The Aging Brain
Authors: Peter Stern, Pamela J. Hines, John Travis
 2014-10-31 [Special Issue News] Starting young
Decades-old IQ test records from Scottish children have opened a unique window on how the brain ages. Author: Emily Underwood
 2014-10-31 [Special Issue Review] Human cognitive aging: Corriger la fortune?
Human cognitive aging differs between and is malleable within individuals. In the absence of a strong genetic program, it is open to a host of hazards, such as vascular conditions, metabolic syndrome, and chronic stress, but also open to protective and enhancing factors, such as experience-dependent cognitive plasticity. Longitudinal studies suggest that leading an intellectually challenging, physically active, and socially engaged life may mitigate losses and consolidate gains. Interventions help to identify contexts and mechanisms of successful cognitive aging and give science and society a hint about what would be possible if conditions were different. Author: Ulman Lindenberger
 2014-10-31 [Special Issue Review] Plasticity of the aging brain: New directions in cognitive neuroscience
Cognitive neuroscience has revealed aging of the human brain to be rich in reorganization and change. Neuroimaging results have recast our framework around cognitive aging from one of decline to one emphasizing plasticity. Current methods use neurostimulation approaches to manipulate brain function, providing a direct test of the ways that the brain differently contributes to task performance for younger and older adults. Emerging research into emotional, social, and motivational domains provides some evidence for preservation with age, suggesting potential avenues of plasticity, alongside additional evidence for reorganization. Thus, we begin to see that aging of the brain, amidst interrelated behavioral and biological changes, is as complex and idiosyncratic as the brain itself, qualitatively changing over the life span. Author: Angela Gutchess
 2014-10-31 [Special Issue Review] Language in the aging brain: The network dynamics of cognitive decline and preservation
Language is a crucial and complex lifelong faculty, underpinned by dynamic interactions within and between specialized brain networks. Whereas normal aging impairs specific aspects of language production, most core language processes are robust to brain aging. We review recent behavioral and neuroimaging evidence showing that language systems remain largely stable across the life span and that both younger and older adults depend on dynamic neural responses to linguistic demands. Although some aspects of network dynamics change with age, there is no consistent evidence that core language processes are underpinned by different neural networks in younger and older adults. Authors: Meredith A. Shafto, Lorraine K. Tyler
 2014-10-31 [Special Issue Review] Economic and social implications of aging societies
The challenge of global population aging has been brought into sharper focus by the financial crisis of 2008. In particular, growing national debt has drawn government attention to two apparently conflicting priorities: the need to sustain public spending on pensions and health care versus the need to reduce budget deficits. A number of countries are consequently reconsidering their pension and health care provisions, which account for up to 40% of all government spending in advanced economies. Yet population aging is a global phenomenon that will continue to affect all regions of the world. By 2050 there will be the same number of old as young in the world, with 2 billion people aged 60 or over and another 2 billion under age 15, each group accounting for 21% of the world’s population. Author: Sarah Harper
 2014-10-31 This Week in Science
Imaging before an unimaginable eruption | Low oxygen limited the rise of animals | Scattering electrons off nuclear targets | History recorded in asteroid's water | A new, yet old, threat to amphibians | Hunting for the effects of huntingtin | Y male plants affect female development | How to increase charitable donations | Nanoparticles for molecular cancer imaging | Supported nanoparticles make the reaction faster | A possible sighting of Majorana states | How to achieve win-win outcomes for biodiversity | You've got to pick a Golgi tether or two | Repressing the right (and not the wrong) mRNA | Making dendritic arbors during development | Epigenetics: It's all about the individual | Pulling me apart only makes me stronger | Overcoming staph infections is hardwired
 2014-10-31 Editors' Choice
A dendritic cell target for immunotherapy | Monitoring the mineral-water interface | Sea-ice loss behind Eurasia's chills | Making a measure of quantum coherence | A drug fights off ravages of aging in mice | A surprise window to the early universe | Cancer's deadly mutational tug of war | Dissecting an RNA that dissects genomes
 2014-10-31 [Research Article] The minimal cadherin-catenin complex binds to actin filaments under force
A protein complex involved in cell adhesion forms a two-state catch bond with the cytoskeleton under mechanical load. Authors: Craig D. Buckley, Jiongyi Tan, Karen L. Anderson, Dorit Hanein, Niels Volkmann, William I. Weis, W. James Nelson, Alexander R. Dunn
 2014-10-31 [Research Article] The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins
Specific proteins can tether and distinguish between specific intracellular transport vesicles in vivo. Authors: Mie Wong, Sean Munro
 2014-10-31 [Research Article] Observation of Majorana fermions in ferromagnetic atomic chains on a superconductor
Scanning tunneling microscopy is used to observe signatures of Majorana states at the ends of iron atom chains. [Also see Perspective by Lee] Authors: Stevan Nadj-Perge, Ilya K. Drozdov, Jian Li, Hua Chen, Sangjun Jeon, Jungpil Seo, Allan H. MacDonald, B. Andrei Bernevig, Ali Yazdani
 2014-10-31 [Research Article] Structural basis for microRNA targeting
Structures of microRNA bound to the Ago2 repressor protein and messenger RNA elucidate target specificity. [Also see Perspective by Patel] Authors: Nicole T. Schirle, Jessica Sheu-Gruttadauria, Ian J. MacRae
 2014-10-31 [Report] Momentum sharing in imbalanced Fermi systems
Electron scattering off various nuclear targets is used to deduce the momentum distributions of nucleons. Authors: O. Hen, M. Sargsian, L. B. Weinstein, E. Piasetzky, H. Hakobyan, D. W. Higinbotham, M. Braverman, W. K. Brooks, S. Gilad, K. P. Adhikari, J. Arrington, G. Asryan, H. Avakian, J. Ball, N. A. Baltzell, M. Battaglieri, A. Beck, S. May-Tal Beck, I. Bedlinskiy, W. Bertozzi, A. Biselli, V. D. Burkert, T. Cao, D. S. Carman, A. Celentano, S. Chandavar, L. Colaneri, P. L. Cole, V. Crede, A. D’Angelo, R. De Vita, A. Deur, C. Djalali, D. Doughty, M. Dugger, R. Dupre, H. Egiyan, A. El Alaoui, L. El Fassi, L. Elouadrhiri, G. Fedotov, S. Fegan, T. Forest, B. Garillon, M. Garcon, N. Gevorgyan, Y. Ghandilyan, G. P. Gilfoyle, F. X. Girod, J. T. Goetz, R. W. Gothe, K. A. Griffioen, M. Guidal, L. Guo, K. Hafidi, C. Hanretty, M. Hattawy, K. Hicks, M. Holtrop, C. E. Hyde, Y. Ilieva, D. G. Ireland, B. I. Ishkanov, E. L. Isupov, H. Jiang, H. S. Jo, K. Joo, D. Keller, M. Khandaker, A. Kim, W. Kim, F. J. Klein, S. Koirala, I. Korover, S. E. Kuhn, V. Kubarovsky, P. Lenisa, W. I. Levine, K. Livingston, M. Lowry, H. Y. Lu, I. J. D. MacGregor, N. Markov, M. Mayer, B. McKinnon, T. Mineeva, V. Mokeev, A. Movsisyan, C. Munoz Camacho, B. Mustapha, P. Nadel-Turonski, S. Niccolai, G. Niculescu, I. Niculescu, M. Osipenko, L. L. Pappalardo, R. Paremuzyan, K. Park, E. Pasyuk, W. Phelps, S. Pisano, O. Pogorelko, J. W. Price, S. Procureur, Y. Prok, D. Protopopescu, A. J. R. Puckett, D. Rimal, M. Ripani, B. G. Ritchie, A. Rizzo, G. Rosner, P. Roy, P. Rossi, F. Sabatié, D. Schott, R. A. Schumacher, Y. G. Sharabian, G. D. Smith, R. Shneor, D. Sokhan, S. S. Stepanyan, S. Stepanyan, P. Stoler, S. Strauch, V. Sytnik, M. Taiuti, S. Tkachenko, M. Ungaro, A. V. Vlassov, E. Voutier, N. K. Walford, X. Wei, M. H. Wood, S. A. Wood, N. Zachariou, L. Zana, Z. W. Zhao, X. Zheng, I. Zonta,
 2014-10-31 [Report] A large magmatic sill complex beneath the Toba caldera
Ambient noise tomography images the magma distribution of a large volcanic reservoir under the Toba caldera. Authors: K. Jaxybulatov, N. M. Shapiro, I. Koulakov, A. Mordret, M. Landès, C. Sens-Schönfelder
 2014-10-31 [Report] Influence of the support on surface rearrangements of bimetallic nanoparticles in real catalysts
A cerium oxide support rendered palladium-rhodium nanoparticles more reactive and harder to reduce under reaction conditions. Authors: Núria J. Divins, Inma Angurell, Carlos Escudero, Virginia Pérez-Dieste, Jordi Llorca
 2014-10-31 [Report] Early accretion of water in the inner solar system from a carbonaceous chondrite–like source
Similar volatile isotopes of Earth and ancient meteorites point to an early accumulation of water for terrestrial bodies. Authors: Adam R. Sarafian, Sune G. Nielsen, Horst R. Marschall, Francis M. McCubbin, Brian D. Monteleone
 2014-10-31 [Report] Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling
Presynaptic granule cell–derived signals drive competitive dendritic morphogenesis of Purkinje cells. Authors: William Joo, Simon Hippenmeyer, Liqun Luo
 2014-10-31 [Report] Recent introduction of a chytrid fungus endangers Western Palearctic salamanders
A new fungal disease from Asia threatens salamanders in Europe, the Middle East, and North Africa. Authors: A. Martel, M. Blooi, C. Adriaensen, P. Van Rooij, W. Beukema, M. C. Fisher, R. A. Farrer, B. R. Schmidt, U. Tobler, K. Goka, K. R. Lips, C. Muletz, K. R. Zamudio, J. Bosch, S. Lötters, E. Wombwell, T. W. J. Garner, A. A. Cunningham, A. Spitzen-van der Sluijs, S. Salvidio, R. Ducatelle, K. Nishikawa, T. T. Nguyen, J. E. Kolby, I. Van Bocxlaer, F. Bossuyt, F. Pasmans
 2014-10-31 [Report] Avoiding overhead aversion in charity
Both seed money and matching approaches increase charity donation rates and amounts. Authors: Uri Gneezy, Elizabeth A. Keenan, Ayelet Gneezy
 2014-10-31 [Report] Low Mid-Proterozoic atmospheric oxygen levels and the delayed rise of animals
Oxygen levels in Earth’s early atmosphere were often less than 1% of modern levels. Authors: Noah J. Planavsky, Christopher T. Reinhard, Xiangli Wang, Danielle Thomson, Peter McGoldrick, Robert H. Rainbird, Thomas Johnson, Woodward W. Fischer, Timothy W. Lyons
 2014-10-31 [Report] A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
Chemical probes may help assign functions to individual members of an important family of epigenetic regulator proteins. Authors: Matthias G. J. Baud, Enrique Lin-Shiao, Teresa Cardote, Cynthia Tallant, Annica Pschibul, Kwok-Ho Chan, Michael Zengerle, Jordi R. Garcia, Terence T.-L. Kwan, Fleur M. Ferguson, Alessio Ciulli
 2014-10-31 [Report] A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus
Cystine-knot proteins play an evolutionarily conserved dual function in nerve development and antistaphylococcal immunity. Authors: Lucy Hepburn, Tomasz K. Prajsnar, Catherine Klapholz, Pablo Moreno, Catherine A. Loynes, Nikolay V. Ogryzko, Karen Brown, Mark Schiebler, Krisztina Hegyi, Robin Antrobus, Katherine L. Hammond, John Connolly, Bernardo Ochoa, Clare Bryant, Michael Otto, Bas Surewaard, Suranjith L. Seneviratne, Dorothy M. Grogono, Julien Cachat, Tor Ny, Arthur Kaser, M. Estée Török, Sharon J. Peacock, Matthew Holden, Tom Blundell, Lihui Wang, Petros Ligoxygakis, Liliana Minichiello, C. Geoff Woods, Simon J. Foster, Stephen A. Renshaw, R. Andres Floto
 2014-10-31 [Report] A Y-chromosome–encoded small RNA acts as a sex determinant in persimmons
The Y chromosome in date plum encodes a small RNA involved in male sex determination. Authors: Takashi Akagi, Isabelle M. Henry, Ryutaro Tao, Luca Comai
 2014-10-31 [New Products] New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
 2014-10-31 [Podcast] Science Podcast: 31 October Show
On this week's show: The changing psychology of charitable giving and a news roundup.
 2014-10-31 [Business Office Feature] Investments Boost Neurotechnology Career Prospects
Jeffrey M. Perkel
 2014-10-31 [Working Life] On the ground in Sierra Leone
Authors: George F. Gao, Yong Feng

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