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BMC Structural Biology - Latest Articles   [more] [xml]
 2014-04-24T00:00:00Z High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster
Background: The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reactive centre loop exons. Eight protein isoforms of Serpin 42 Da have been identified to date, targeting the protease inhibitor to both different proteases and cellular locations. Biochemical and genetic studies suggest that Serpin 42 Da inhibits target proteases through the classical serpin 'suicide' inhibition mechanism, however the crystal structure of a representative Serpin 42 Da isoform remains to be determined. Results: We report two high-resolution crystal structures of Serpin 42 Da representing the A/B isoforms in the cleaved conformation, belonging to two different space-groups and diffracting to 1.7 A and 1.8 A. Structural analysis reveals the archetypal serpin fold, with the major elements of secondary structure displaying significant homology to the vertebrate serpin, neuroserpin. Key residues known to have central roles in the serpin inhibitory mechanism are conserved in both the hinge and shutter regions of Serpin 42 Da. Furthermore, these structures identify important conserved interactions that appear to be of crucial importance in allowing the Serpin 42 Da fold to act as a versatile template for multiple reactive centre loops that have different sequences and protease specificities. Conclusions: In combination with previous biochemical and genetic studies, these structures confirm for the first time that the Serpin 42 Da isoforms are typical inhibitory serpin family members with the conserved serpin fold and inhibitory mechanism. Additionally, these data reveal the remarkable structural plasticity of serpins, whereby the basic fold is harnessed as a template for inhibition of a large spectrum of proteases by reactive centre loop exon 'switching'. This is the first structure of a Drosophila serpin reported to date, and will provide a platform for future mutational studies in Drosophila to ascertain the functional role of each of the Serpin 42 Da isoforms.


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BMC Bioinformatics - Latest Articles   [more] [xml]
 2014-04-24T00:00:00Z Identifying pathogenic processes by integrating microarray data with prior knowledge
Background: It is of great importance to identify molecular processes and pathways that are involved in disease etiology. Although there has been an extensive use of various high-throughput methods for this task, pathogenic pathways are still not completely understood. Often the set of genes or proteins identified as altered in genome-wide screens show a poor overlap with canonical disease pathways. These findings are difficult to interpret, yet crucial in order to improve the understanding of the molecular processes underlying the disease progression. We present a novel method for identifying groups of connected molecules from a set of differentially expressed genes. These groups represent functional modules sharing common cellular function and involve signaling and regulatory events. Specifically, our method makes use of Bayesian statistics to identify groups of co-regulated genes based on the microarray data, where external information about molecular interactions and connections are used as priors in the group assignments. Markov chain Monte Carlo sampling is used to search for the most reliable grouping. Results: Simulation results showed that the method improved the ability of identifying correct groups compared to traditional clustering, especially for small sample sizes. Applied to a microarray heart failure dataset the method found one large cluster with several genes important for the structure of the extracellular matrix and a smaller group with many genes involved in carbohydrate metabolism. The method was also applied to a microarray dataset on melanoma cancer patients with or without metastasis, where the main cluster was dominated by genes related to keratinocyte differentiation. Conclusion: Our method found clusters overlapping with known pathogenic processes, but also pointed to new connections extending beyond the classical pathways.


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BMC Genomics - Latest Articles   [more] [xml]
 2014-04-24T00:00:00Z Development and evaluation of the first high-throughput SNP array for common carp (Cyprinus carpio)
Background: A large number of single nucleotide polymorphisms (SNPs) have been identified in common carp (Cyprinus carpio) but, as yet, no \high-throughput genotyping platform is available for this species. C. carpio is an important aquaculture species that accounts for nearly 14% of freshwater aquaculture production worldwide. We have developed an array for C. carpio with 250,000 SNPs and evaluated its performance using samples from various strains of C. carpio. Results: The SNPs used on the array were selected from two resources: the transcribed sequences from RNA-seq data of four strains of C. carpio, and the genome re-sequencing data of five strains of C. carpio. The 250,000 SNPs on the resulting array are distributed evenly across the reference C.carpio genome with an average spacing of 6.6 kb. To evaluate the SNP array, 1,072 C. carpio samples were collected and tested. Of the 250,000 SNPs on the array, 185,150 (74.06%) were found to be polymorphic sites. Genotyping accuracy was checked using genotyping data from a group of full-siblings and their parents, and over 99.8% of the qualified SNPs were found to be reliable. Analysis of the linkage disequilibrium on all samples and on three domestic C.carpio strains revealed that the latter had the longer haplotype blocks. We also evaluated our SNP array on 80 samples from eight species related to C. carpio, with from 53,526 to 71,984 polymorphic SNPs. An identity by state analysis divided all the samples into three clusters; most of the C. carpio strains formed the largest cluster. Conclusions: The Carp SNP array described here is the first high-throughput genotyping platform for C. carpio. Our evaluation of this array indicates that it will be valuable for farmed carp and for genetic and population biology studies in C. carpio and related species.


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BMC Biochemistry - Latest Articles   [more] [xml]
 2014-04-03T00:00:00Z Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
Background: Human malaria parasite infection and its control is a global challenge which is responsible for ~0.65 million deaths every year globally. The emergence of drug resistant malaria parasite is another challenge to fight with malaria. Enormous efforts are being made to identify suitable drug targets in order to develop newer classes of drug. Helicases play crucial roles in DNA metabolism and have been proposed as therapeutic targets for cancer therapy as well as viral and parasitic infections. Genome wide analysis revealed that Plasmodium falciparum possesses UvrD helicase, which is absent in the human host. Results: Recently the biochemical characterization of P. falciparum UvrD helicase revealed that N-terminal UvrD (PfUDN) hydrolyses ATP, translocates in 3’ to 5’ direction and interacts with MLH to modulate each other’s activity. In this follow up study, further characterization of P. falciparum UvrD helicase is presented. Here, we screened the effect of various DNA interacting compounds on the ATPase and helicase activity of PfUDN. This study resulted into the identification of daunorubicin (daunomycin), netropsin, nogalamycin, and ethidium bromide as the potential inhibitor molecules for the biochemical activities of PfUDN with IC50 values ranging from ~3.0 to ~5.0 μM. Interestingly etoposide did not inhibit the ATPase activity but considerable inhibition of unwinding activity was observed at 20 μM. Further study for analyzing the importance of PfUvrD enzyme in parasite growth revealed that PfUvrD is crucial/important for its growth ex-vivo. Conclusions: As PfUvrD is absent in human hence on the basis of this study we propose PfUvrD as suitable drug target to control malaria. Some of the PfUvrD inhibitors identified in the present study can be utilized to further design novel and specific inhibitor molecules.


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Nature   [more] [xml]
 2005-01-19 Einstein is dead
Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.

Einstein is dead

Nature 433, 179 (2005). doi:10.1038/433179a

Until its next revolution, much of the glory of physics will be in engineering. It is a shame that the physicists who do so much of it keep so quiet about it.



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Science: Current Issue   [more] [xml]
 2014-04-25 This Week in Science
Double Helix, Doubled | Africa's Bane | Understanding N Loss | Optogenetic Insights | A Dual Approach to 2 + 2 | Wetted Apatite | House or Face? | No Light Control | Magnified Flare-Up | Deep Freeze | RNA Heteroplasmy | Cyanobacterial Diversity
 2014-04-25 [Editorial] Addressing Vaccine Hesitancy
Last month, the World Health Organization certified India and Southeast Asia as being polio-free, an extraordinary achievement given that the polio vaccine was declared safe and effective only 59 years ago. Vaccines are one of the safest and most cost-effective medical interventions in history. By immunizing infants, children, and teenagers, vaccines protect the entire community. Nevertheless, there is a surge of outbreaks in vaccine-preventable diseases in the United States. What research is needed to reverse this trend? Authors: Barry R. Bloom, Edgar Marcuse, Seth Mnookin
 2014-04-25 Editors' Choice
Rivers of Words | Expelled Xe | Safe Sopping | Slime Fibers | Blood and Brains | Sleep Circuit | AFM Uncompromised
 2014-04-25 [News of the Week] This Week's Section
Follow the links below for a roundup of the week's top stories in science, or download a PDF of the entire section. Around the WorldFindingsRandom SamplesNewsmakers
 2014-04-25 [News of the Week] Around the World
In science news around the world, the European Space Agency's new environmental satellite Sentinel-1A sends back its first radar images of Earth, polio spreads farther into Central Africa, China releases new information on its polluted soil, and more.
 2014-04-25 [News of the Week] Random Sample
NASA's Cassini spacecraft spies a new moon forming in Saturn's outermost ring, which scientists hope will offer insight into the formation of the planet's other icy moons within its now-vanished, even more massive rings.
 2014-04-25 [News of the Week] Newsmakers
Science has won two awards this past month: Contributing correspondent Ann Gibbons won an award from the Society for American Archaeology for her writing in the immersive multimedia story "The Thousand-Year Graveyard"; and Deputy News Editor Leslie Roberts won an award from the Association of Health Care Journalists for her story "The Art of Eradicating Polio."
 2014-04-25 Findings
New Stem Cells a Genetic Match for Adults
 2014-04-25 [News & Analysis] Climate Outsider Finds Missing Global Warming
New analyses show that major climate data sets have overstated the recent slowdown in global warming. Author: Eli Kintisch
 2014-04-25 [News & Analysis] Genome Yields Clues to Tsetse Fly's Strange and Deadly Ways
Sequencing the genome and assessing gene activity in various tissues in the tsetse fly led to new insights into its biology and the control of parasitic diseases transmitted by this insect. Author: Elizabeth Pennisi
 2014-04-25 [News & Analysis] At NIH, Two Strikes Policy Is Out
Responding to complaints, the National Institutes of Health will no longer limit the number of times a researcher can resubmit a rejected grant proposal. Author: Jocelyn Kaiser
 2014-04-25 [News & Analysis] Potential Alzheimer's Drug Spurs Protein Recycling
A research team has identified a potential new drug lead for Alzheimer's disease: a small molecule that stabilizes the components of retromers, molecular complexes that act like recycling bins in cells. Author: Ken Garber
 2014-04-25 [News Focus] Tanks for the Batteries
The need to store energy from wind, solar, and other renewable energy sources could spark a revival of a dormant battery technology. Author: Robert F. Service
 2014-04-25 [News Focus] After the Deluge
Hard data and survivor interviews are helping researchers unravel the science of Supertyphoon Haiyan and its storm surge. Author: Dennis Normile
 2014-04-25 [News Focus] The Cyclone Addict
Storm chaser Josh Morgerman witnessed Supertyphoon Haiyan as it hit Tacloban, and he went back months later to document the storm's track and impact. Author: Dennis Normile
 2014-04-25 [Letter] Protecting Lemurs: Madagascar's Forests
Authors: William J. McConnell, Christian A. Kull
 2014-04-25 [Letter] Protecting Lemurs: Ecotourism
Author: Ralf Buckley
 2014-04-25 [Letter] Protecting Lemurs—Response
Authors: Christoph Schwitzer, Lounes Chikhi, Giuseppe Donati, Mitchell Irwin, Steig E. Johnson, Russell A. Mittermeier, Heather Peacock, Jonah Ratsimbazafy, Josia Razafindramanana, Edward E. Louis, Ian C. Colquhoun, Jen Tinsman, Rainer Dolch, Marni LaFleur, Stephen Nash, Erik Patel, Blanchard Randrianambinina, Tovonanahary Rasolofoharivelo, Patricia C. Wright
 2014-04-25 [Technical Comment] Comment on “A Complete Skull from Dmanisi, Georgia, and the Evolutionary Biology of Early Homo”
Lordkipanidze et al. (Research Article, 18 October 2013, p. 326) conclude, from gross morphological comparisons and geometric-morphometric analysis of general shape, that the five hominid crania from Dmanisi in Georgia represent a single regional variant of Homo erectus. However, dental, mandibular, and cranial morphologies all suggest taxic diversity and, in particular, validate the previously named H. georgicus. Authors: Jeffrey H. Schwartz, Ian Tattersall, Zhang Chi
 2014-04-25 [Technical Response] Response to Comment on “A Complete Skull from Dmanisi, Georgia, and the Evolutionary Biology of Early Homo”
Schwartz et al. hold that variation among the Dmanisi skulls reflects taxic diversity. The morphological observations to support their hypothesis, however, are partly incorrect, and not calibrated against intraspecific variation in living taxa. After proper adjustment, Schwartz et al.’s data are fully compatible with the hypothesis of a single paleodeme of early Homo at Dmanisi. Authors: Christoph P. E. Zollikofer, Marcia S. Ponce de León, Ann Margvelashvili, G. Philip Rightmire, David Lordkipanidze
 2014-04-25 [Correction] Corrections and Clarifications
 2014-04-25 [Book Review] Reproductions Through Technology
Franklin explores how the development of in vitro fertilization into a routine procedure has changed our understanding of technology and biology. Author: Charis Thompson
 2014-04-25 [Book Review] To Best Rule the Net
Examining technologies and policies, DeNardis considers the politics behind Internet protocols and the many groups vying to influence them. Author: Daniel J. Weitzner
 2014-04-25 [Books et al.] Books Received
A listing of books received at Science during the week ending 18 April 2014.
 2014-04-25 [Policy Forum] Cracking Brazil's Forest Code
Brazil's controversial new Forest Code grants amnesty to illegal deforesters, but creates new mechanisms for forest conservation. Authors: Britaldo Soares-Filho, Raoni Rajão, Marcia Macedo, Arnaldo Carneiro, William Costa, Michael Coe, Hermann Rodrigues, Ane Alencar
 2014-04-25 [Perspective] Analyzing Moon Rocks
A better inventory of lunar volatiles will help improve our understanding of the origin and evolution of the Earth-Moon system. [Also see Report by Boyce et al.] Author: Mahesh Anand
 2014-04-25 [Perspective] Being Selective in the Prochlorococcus Collective
Single-cell sequencing reveals the microdiversity of the most abundant photosynthetic organism on Earth. [Also see Report by Kashtan et al.] Authors: Chris Bowler, David J. Scanlan
 2014-04-25 [Perspective] A Two-Catalyst Photochemistry Route to Homochiral Rings
A synthetic route photoactivates one reactant and then controls stereochemistry of subsequent steps to form a single isomer of a four-membered ring. [Also see Report by Du et al.] Author: Reinhard Neier
 2014-04-25 [Perspective] Silencing Neurons with Light
Engineered channelrhodopsins conduct anions rather than cations, changing the action potential of neurons. [Also see Reports by Wietek et al. and Berndt et al.] Author: Shigehiko Hayashi
 2014-04-25 [Perspective] The 30-nm Fiber Redux
Do alternating stacking modes of nucleosomes underlie the compaction of chromatin? [Also see Research Article by Song et al.] Author: Andrew Travers
 2014-04-25 [Perspective] Mapping Neural Activation onto Behavior in an Entire Animal
A combination of technologies reveals which neurons constitute circuits for specific behaviors in Drosophila larvae. [Also see Research Article by Vogelstein et al.] Authors: Timothy O'Leary, Eve Marder
 2014-04-25 [Perspective] Carbon Storage in Basalt
Field projects are beginning to demonstrate the potential for carbon storage in basaltic rocks. Authors: Sigurdur R. Gislason, Eric H. Oelkers
 2014-04-25 [Research Article] Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units
The structure of a segment of chromatin reveals the importance of the linker histone in determining its conformation. [Also see Perspective by Travers] Authors: Feng Song, Ping Chen, Dapeng Sun, Mingzhu Wang, Liping Dong, Dan Liang, Rui-Ming Xu, Ping Zhu, Guohong Li
 2014-04-25 [Research Article] Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis
Blood-sucking tsetses transmit protozoan parasites, harbor multiple symbionts, reproduce viviparously, and lactate. Authors: , Geoffrey M. Attardo, Patrick P. Abila, Joanna E. Auma, Aaron A. Baumann, Joshua B. Benoit, Corey L. Brelsfoard, José M. C. Ribeiro, James A. Cotton, Daphne Q. D. Pham, Alistair C. Darby, Jan Van Den Abbeele, David L. Denlinger, Linda M. Field, Steven R. G. Nyanjom, Michael W. Gaunt, Dawn L. Geiser, Ludvik M. Gomulski, Lee R. Haines, Immo A. Hansen, Jeffery W. Jones, Caleb K. Kibet, Johnson K. Kinyua, Denis M. Larkin, Michael J. Lehane, Rita V. M. Rio, Sandy J. Macdonald, Rosaline W. Macharia, Anna R. Malacrida, Heather G. Marco, Kevin K. Marucha, Daniel K. Masiga, Megan E. Meuti, Paul O. Mireji, George F. O. Obiero, Jacobus J. O. Koekemoer, Chinyere K. Okoro, Irene A. Omedo, Victor C. Osamor, Apollo S. P. Balyeidhusa, Justin T. Peyton, David P. Price, Michael A. Quail, Urvashi N. Ramphul, Neil D. Rawlings, Michael A. Riehle, Hugh M. Robertson, Mandy J. Sanders, Maxwell J. Scott, Zahra Jalali Sefid Dashti, Anna K. Snyder, Tulika P. Srivastava, Eleanor J. Stanley, Martin T. Swain, Daniel S. T. Hughes, Aaron M. Tarone, Todd D. Taylor, Erich L. Telleria, Gavin H. Thomas, Deirdre P. Walshe, Richard K. Wilson, Joy J. Winzerling, Alvaro Acosta-Serrano, Serap Aksoy, Peter Arensburger, Martin Aslett, Rosemary Bateta, Alia Benkahla, Matthew Berriman, Kostas Bourtzis, Jelle Caers, Guy Caljon, Alan Christoffels, Marco Falchetto, Markus Friedrich, Shuhua Fu, Gerd Gäde, George Githinji, Richard Gregory, Neil Hall, Gordon Harkins, Masahira Hattori, Christiane Hertz-Fowler, Winston Hide, Wanqi Hu, Tadashi Imanishi, Noboru Inoue, Mario Jonas, Yoshihiro Kawahara, Mathurin Koffi, Adele Kruger, Daniel Lawson, Stella Lehane, Heikki Lehväslaiho, Thiago Luiz, Mmule Makgamathe, Imna Malele, Oliver Manangwa, Lucien Manga, Karyn Megy, Veronika Michalkova, Feziwe Mpondo, Furaha Mramba, Atway Msangi, Nicola Mulder, Grace Murilla, Sarah Mwangi, Loyce Okedi, Sheila Ommeh, Cher-Pheng Ooi, Johnson Ouma, Sumir Panji, Sophie Ravel, Clair Rose, Ryuichi Sakate, Liliane Schoofs, Francesca Scolari, Vineet Sharma, Cheolho Sim, Geoffrey Siwo, Philippe Solano, Dawn Stephens, Yutaka Suzuki, Sing-Hoi Sze, Yeya Touré, Atsushi Toyoda, George Tsiamis, Zhijian Tu, Mark Wamalwa, Florence Wamwiri, Jingwen Wang, Wesley Warren, Junichi Watanabe, Brian Weiss, Judith Willis, Patrick Wincker, Qirui Zhang, Jing-Jiang Zhou
 2014-04-25 [Research Article] Discovery of Brainwide Neural-Behavioral Maps via Multiscale Unsupervised Structure Learning
An atlas is generated to reveal activation of which specific neurons in a Drosophila larva produce specific behaviors. [Also see Perspective by O'Leary and Marder] Authors: Joshua T. Vogelstein, Youngser Park, Tomoko Ohyama, Rex A. Kerr, James W. Truman, Carey E. Priebe, Marta Zlatic
 2014-04-25 [Report] A Dual-Catalysis Approach to Enantioselective [2 + 2] Photocycloadditions Using Visible Light
A two-catalyst combination offers long-sought selectivity in intermolecular coupling of olefins to form four-membered rings. [Also see Perspective by Neier] Authors: Juana Du, Kazimer L. Skubi, Danielle M. Schultz, Tehshik P. Yoon
 2014-04-25 [Report] Detection of the Gravitational Lens Magnifying a Type Ia Supernova
An unusually bright supernova faded away to reveal a foreground galaxy responsible for bending and amplifying its light. Authors: Robert M. Quimby, Masamune Oguri, Anupreeta More, Surhud More, Takashi J. Moriya, Marcus C. Werner, Masayuki Tanaka, Gaston Folatelli, Melina C. Bersten, Keiichi Maeda, Ken’ichi Nomoto
 2014-04-25 [Report] The Lunar Apatite Paradox
Hydrogen-rich apatite crystals in lunar volcanic rocks indicate self-inflicted loss of fluorine from basaltic melts. [Also see Perspective by Anand] Authors: J. W. Boyce, S. M. Tomlinson, F. M. McCubbin, J. P. Greenwood, A. H. Treiman
 2014-04-25 [Report] Preservation of a Preglacial Landscape Under the Center of the Greenland Ice Sheet
Soil has been frozen to the central part of the bed of the Greenland Ice Sheet for at least 2.7 million years. Authors: Paul R. Bierman, Lee B. Corbett, Joseph A. Graly, Thomas A. Neumann, Andrea Lini, Benjamin T. Crosby, Dylan H. Rood
 2014-04-25 [Report] Organic Matter Stoichiometry, Flux, and Oxygen Control Nitrogen Loss in the Ocean
The variable ratio of denitrification to anammox in the ocean is due to variations in organic matter quality and quantity. Authors: Andrew R. Babbin, Richard G. Keil, Allan H. Devol, Bess B. Ward
 2014-04-25 [Report] Conversion of Channelrhodopsin into a Light-Gated Chloride Channel
A class of directly light-gated anion channels can be used to block neuronal output in a fully reversible fashion. [Also see Perspective by Hayashi and Report by Berndt et al.] Authors: Jonas Wietek, J. Simon Wiegert, Nona Adeishvili, Franziska Schneider, Hiroshi Watanabe, Satoshi P. Tsunoda, Arend Vogt, Marcus Elstner, Thomas G. Oertner, Peter Hegemann
 2014-04-25 [Report] High-Resolution Genomic Analysis of Human Mitochondrial RNA Sequence Variation
Mitochondrial posttranscriptional variation is common among humans and can be attributed to a nuclear gene. Authors: Alan Hodgkinson, Youssef Idaghdour, Elias Gbeha, Jean-Christophe Grenier, Elodie Hip-Ki, Vanessa Bruat, Jean-Philippe Goulet, Thibault de Malliard, Philip Awadalla
 2014-04-25 [Report] Single-Cell Genomics Reveals Hundreds of Coexisting Subpopulations in Wild Prochlorococcus
Covariation between the core alleles and flexible gene content of a marine cyanobacterium underpins vast diversity. [Also see Perspective by Bowler and Scanlan] Authors: Nadav Kashtan, Sara E. Roggensack, Sébastien Rodrigue, Jessie W. Thompson, Steven J. Biller, Allison Coe, Huiming Ding, Pekka Marttinen, Rex R. Malmstrom, Roman Stocker, Michael J. Follows, Ramunas Stepanauskas, Sallie W. Chisholm
 2014-04-25 [Report] Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel
A class of directly light-gated anion channels can be used to block neuronal output in a fully reversible fashion. [Also see Perspective by Hayashi and Report by Wietek et al.] Authors: Andre Berndt, Soo Yeun Lee, Charu Ramakrishnan, Karl Deisseroth
 2014-04-25 [Report] Neural Mechanisms of Object-Based Attention
Brain imaging reveals how the brain can selectively attend to one of two overlapping objects. Authors: Daniel Baldauf, Robert Desimone
 2014-04-25 [Report] A Chloroplast Retrograde Signal Regulates Nuclear Alternative Splicing
In plants, light-dependent regulation of nuclear alternative splicing involves a signal generated within the chloroplast. Authors: Ezequiel Petrillo, Micaela A. Godoy Herz, Armin Fuchs, Dominik Reifer, John Fuller, Marcelo J. Yanovsky, Craig Simpson, John W. S. Brown, Andrea Barta, Maria Kalyna, Alberto R. Kornblihtt
 2014-04-25 [New Products] New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
 2014-04-25 [Podcast] Science Podcast: 25 April Show
On this week's show: the genome sequence of the tsetse fly and a roundup of stories from our daily news site.
 2014-04-25 [Business Office Feature] Targeting Telomeres in Human Disease: Advances and Therapeutic Opportunities
Roger Reddel

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