The Prolinks Database



PP: Phylogenetic Profie method
RS: Rosetta Stone or Gene Fusion method
GN: Gene Neighbor Method
GC: Gene Cluster Method (similar to the Operon method (OP)


The Prolinks database is a collection of inference methods used
to predict functional linkages between proteins. These methods include
the Phylogenetic Profile (PP) method which uses the presence and absence of
proteins across multiple genomes to detect functional linkages; the Gene
Cluster (GC) method , which uses genome proximity to predict functional linkage;
Rosetta Stone (RS), which uses a gene fusion event in a second organism to infer
functional relatedness; and the Gene Neighbor (GN) method, which uses both gene
proximity and phylogenetic distribution to infer linkage. Please see the
literature references for further details.


To access the Prolinks-Database:
http://www.doe-mbi.ucla.edu
http://mysql5.mbi.ucla.edu/cgi-bin/functionator/pronav