Saccharomyces cerevisiae
Yeast Protein Function Assignment
All links
or choose from the complete list of yeast ORFS.
Approximately 94,000 unique links have been established between 4701 of the 6217 proteins of
Saccharomyces cerevisiae by methods described in
Assigning Protein Functions by Comparative Genome Analysis:
Protein Phylogenetic Profiles
(Proc. Natl. Acad. Sci 96:4285-4288 (1999), link to PNAS
abstract or Medline abstract)
and in
Detecting Protein Function and
Protein-Protein Interactions from Genome Sequences
(
Science 285:751-753 (1999),
link to Science abstract or
Medline abstract).
Of the 94,000 links, about
2500 links are derived from known experimental interactions in the
DIP database and MIPS
database and
from yeast proteins whose E. coli homologs catalyze sequential metabolic reactions (as defined in the
EcoCyc database),
and about 26,000 links are generated from proteins whose mRNAs show correlated expression patterns using publicly available
gene chip data from the Stanford Genomic group
and Pat Brown's Lab.
Lastly, we predict a protein's function from the function of proteins that it is linked to using the hierarchal annotations of the MIPS yeast database.
Explanation of the prediction methods, error rates, etc. appears in
A Combined Algorithm for Genome-Wide Prediction of Protein Function (
Nature 402:83-86 (1999), link to
Nature abstract).
Alternatively, look for links in our somewhat smaller, higher confidence set of ~24,000 links, covering 2356 of the 6217 yeast proteins.
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Please address comments to: Edward Marcotte
This site is not intended for commercial use. Commercial users should contact Protein Pathways, Inc.
Last modified: Fri Nov 11 11:05:20 MET 1999
Copyright © 1999, Edward Marcotte and David Eisenberg. The yeast protein function
assignment data and server is the property of the Regents of the University of California, and cannot be used for
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