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PresenterDateTitle
King,NeilNov 16, 2009Direct inhibition of the NOTCH transcription factor complex. Nature. 2009 Nov 12;462(7270):182-8..
Chang, HowardNov 9, 2009Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift. Science 30 October 2009: Vol. 326. no. 5953, pp. 734 - 736.
Crowley, ChristopherNov 2, 2009Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009 Oct 29;461(7268):1282-6..
Tanaka, ShihoOct 26, 2009The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA. Science. 2009 Oct 15. [Epub ahead of print].
Salwinski, LukaszOct 19, 2009Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15;461(7266):997-1001..
Miallau, LindaOct 5, 2009Gene therapy for red-green colour blindness in adult primates. Nature. 2009 Sep 16. [Epub ahead of print].
Landau, MeytalSep 28, 2009Positive Selection of Tyrosine Loss in Metazoan Evolution. Science 25 September 2009: Vol. 325. no. 5948, pp. 1686 - 1688.
Liu, CongSep 21, 2009Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nat Struct Mol Biol. 2009 Sep 13. [Epub ahead of print].
Laganowsky, ArthurSep 14, 2009Promiscuous Substrate Recognition in Folding and Assembly Activities of the Trigger Factor Chaperone. Cell, Volume 138, Issue 5, 923-934, 4 September 2009 .
Li, DanAug 31, 2009Myosin VI undergoes cargo-mediated dimerization. Cell. 2009 Aug 7;138(3):537-48..
Apostol, MarcinAug 24, 2009Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science 2009 Aug 21;325(5943):966-70..
Llewellyn, RichardAug 17, 2009The Secret Life of the Anthrax Agent Bacillus anthracis: Bacteriophage-Mediated Ecological Adaptations. PLoS One. 2009 Aug 12;4 (8) :e6532.
Forse, JasonAug 10, 2009Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nature Structural & Molecular Biology 16, 890 - 896 (2009) .
Sievers, StuartAug 3, 2009Synthetic protein scaffolds provide modular control over metabolic flux. Nature Biotechnology Published online: 2 August 2009.
Ivanova,MagdalenaJul 27, 2009Helical extension of the neuronal SNARE complex into the membrane. Nature 460, 525-528 2009 .
Goldschmidt, LukaszJul 20, 2009Motif-directed flexible backbone design of functional interactions. Protein Sci. 2009 Jun;18(6):1293-305..
Sievers, StuartJul 13, 2009structure of a prokaryotic virtual proton pump at 3.2 angstrom resolution. Nature advance online publication 5 july 2009.
Zhao, MingleiJun 22, 2009Diversity and Complexity in DNA Recognition by Transcription Factors. Science Epub ahead of print.
Medrano-Soto, ArturoJun 15, 2009X-Ray Structures of the Hexameric Building Block of the HIV Capsid.
Teng, PohJun 1, 2009Fabricating genetically engineered high-power lithium-ion batteries using multiple virus genes. Science. 2009 May 22;324(5930):1051-5. .
Park, JiyongMay 18, 2009Branching in amyloid fibril growth. Biophys J. 2009 Feb 18;96(4):1529-36..
Tsai, YingssuMay 11, 2009Structural studies of the giant mimivirus. PLoS Biol. 2009 Apr 28;7(4):e92..
Stroud, JamesMay 4, 2009A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell 2009 Apr 17;137(2):308-20..
Zhao, AnniApr 27, 2009Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism. Nature Structural & Molecular Biology 16, 380 - 389 (2009) .
Soriaga, AngelaApr 13, 2009Coding-sequence determinants of gene expression in Escherichia coli. Science 2009 Apr 10;324(5924):255-8..
Sawaya, MichaelApr 6, 2009Structure of the connexin 26 gap junction channel at 3.5 A resolution. Nature 2009.
Chang, HowardMar 23, 2009Design and engineering of an O(2) transport protein. Nature 2009 Mar 19;458(7236):305-9..
Liu, CongMar 16, 2009Interprotofilament interactions between Alzheimer's A{beta}1-42 peptides in amyloid fibrils revealed by cryoEM. PNAS 2009 Mar 5. [Epub ahead of print].
Tanaka, ShihoMar 9, 2009Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. PNAS 2009 Mar 3;106(9):3059-64. .
Salwinski, LukaszMar 2, 2009A hierarchical model for evolution of 23S ribosomal RNA. Nature 2009 457(7232):977-80. .
Crowley, ChristopherFeb 23, 2009Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature 2009 Feb 1. [Epub ahead of print].
President's Day Holiday - No meeting,Feb 16, 2009Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation. J. Biol. Chem., Vol. 284, Issue 6, 3917-3924, 2009.
Li, DanFeb 2, 2009Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB. Science Vol. 323. no. 5912, pp. 396 - 401.
Martin Luther King Holiday - No meeting,Jan 19, 2009High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography. PLoS Biol. 2008 Dec 16;6(12):e311..
Forse, JasonJan 5, 2009Quality control by the ribosome following peptide bond formation. Nature 457, 161-166 (8 January 2009).
Llewellyn, RichardDec 15, 2008Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity. Cell, Volume 135, Issue 6, 12 December 2008, Pages 1085-1097 .
Ivanova,MagdalenaDec 8, 2008Initiation and elongation in fibrillation of ALS-linked superoxide dismutase. PNAS December 2, 2008 vol. 105 .
McFarlane, HeatherDec 1, 2008Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils. PNAS 2008 105:18349-18354.
Kaufmann, MarkusNov 24, 2008The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist. Science 322 no. 5905, pp. 1211 - 1217 2008 .
Park, JiyongNov 17, 2008A Molecular Dynamics Study of the Interaction of d-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation. J Mol Biol. 2008 Oct 31;383(1):266-80 .
Goldschmidt, LukaszNov 10, 2008Fragment-HMM: A new approach to protein structure prediction. Protein Science (2008), 17:1925-1934. .
Sievers, StuartNov 3, 2008Interactions between Hsp70 and the Hydrophobic Core of alpha-Synuclein Inhibit Fibril Assembly. ASAP Biochemistry. Web Release Date: November 1, 2008 .
Sprinzak, EinatOct 27, 2008Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy. Science. 2008 Oct 9. [Epub ahead of print].
Zhao, MingleiOct 20, 2008Surface sites for engineering allosteric control in proteins. Science. 2008 Oct 17;322(5900):438-42..
Soriaga, AngelaOct 13, 2008Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines (PNAS, 7 Oct 2008, 105:15334).
Medrano-Soto, ArturoOct 6, 2008Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies (PLoS Comput. Biol, 1 Aug 2008, 4:e1000142).
Zhao,AnniSep 29, 2008A regulatable switch mediates self-association in an immunoglobulin fold (NSMB, Sept. 2008, 15:965).
Wiltzius, JedSep 22, 2008Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield (PNAS, 16 Sept 2008, 105:13769).
Laganowsky, ArthurSep 15, 2008Chemical and biological approaches synergize to ameliorate protein-folding diseases (Cell, 5 Sept 2008, 134:769) .
Tsai, YingssuAug 25, 2008Evolutionary ecology of pungency in wild chilies (PNAS, 19 Aug 2008, 105:11808).
Stroud, JamesAug 11, 2008Secreted transcription factor controls Mycobacterium tuberculosis virulence (Nature, 7 Aug 2008, 454:717).
Sawaya, MichaelAug 4, 2008Crystal structure of the termination module of a nonribosomal peptide synthetase (Science, 1 Aug 2008, 321:659).
Tanaka, ShihoJul 28, 20081. Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU (Nature, AOP 23 July 2008); 2. The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency (Nature, AOP 23 July 2008) .
Chang, HowardJul 21, 2008Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT (Nat. Struct. Molec. Biol., July 2008, 15:746).
King,NeilJul 14, 2008Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor (Nature, 10 July 2008, 454:177).
Landau, MeytalJul 7, 2008Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease (JBC, 4 July 2008, 283:19058).
Salwinski, LukaszJun 30, 2008Functional maps of protein complexes from quantitative genetic interaction data (PLoS Comput. Biol., April 2008, 4(4):e1000065).
Crowley, ChristopherJun 23, 2008Assembly reflects evolution of protein complexes (Nature, 26 June 2008, 453:1262).
Apostol, MarcinJun 16, 2008Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution (Science, 13 June 2008, 320: 1471).
Miller, ChristopherJun 9, 2008Predictive behavior within microbial genetic networks (Science, 6 June 2008, 320:1313).
Crowley, ChristopherJun 2, 2008Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins (PNAS, 3 June 2008, 105:7702); Structural basis for the regulated protease and chaperone function of DegP (Nature, advance online publication 21 May 2008).
Ivanova,MagdalenaMay 12, 2008Genome analysis of the platypus reveals unique signatures of evolution (Nature, 8 May 2008, 453:175).
Kaufmann, MarkusApr 21, 2008Bacteria subsisting on antibiotics (Science 4 April 2008: 100-103).
Miallau, LindaApr 14, 2008Opening and closing of the periplasmic gate in lactose permease (PNAS, 11 Mar 2008, 105:3774-8).
Lee, ToniMar 31, 2008Kemp elimination catalysts by computational enzyme design (Nature, advance online publication 19 March 2008).
Llewellyn, RichardMar 24, 2008Two Seemingly Homologous Noncoding RNAs Act Hierarchically to Activate glmS mRNA Translation (PLoS Biology, March 2008, 6(3): e6).
Sprinzak, EinatMar 10, 2008Intrinsically disordered proteins display no preference for chaperone binding in vivo. (PLoS Comp. Biol. Feb 2008).
Zhao, MingleiMar 3, 2008A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing (Nature, 6 Mar 2008, 452:108).
Medrano-Soto, ArturoFeb 25, 2008Genome-wide experimental determination of barriers to horizontal gene transfer (Science, 30 Nov 2007, 318:1449).
Laganowsky, ArthurFeb 11, 2008Structural basis for the function and inhibition of an influenza virus proton channel (Nature, 31 Jan 2008, 451:596), Structure and mechanism of the M2 proton channel of influenza A virus (Nature, 31 Jan 2008, 451:591).
Norcross, ToddFeb 4, 2008Petri net-based method for the analysis of the dynamics of signal propagation in signalling pathways (Bioinformatics, 15 Jan 2008, 24:209).
Tsai, YingssuJan 28, 2008Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages (PNAS, 22 Jan 2008, 105:1009).
Wiltzius, JedJan 14, 2008Designed protein-protein association (Science, 11 Jan 2008, 319:206).
Stroud, JamesJan 7, 2008Host genome surveillance for retrotransposons by transposon-derived proteins (Nature, 19 Dec 2007, epub ahead of print).
Sawaya, MichaelDec 17, 2007Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin (Science, 2007 Dec 6, epub ahead of print).
Teng, PohDec 10, 2007Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion (PLoS ONE, 2007 Oct 24, 2:e1082).
Colletier, Jacques-PhilippeNov 26, 2007A hierarchy of timescales in protein dynamics is linked to enzyme catalysis.
Cam Mura, guest speakerNov 19, 2007Cooperation and conflict in quorum-sensing bacterial populations (Nature, 15 Nov 2007, 450:411); a linear pentapeptide is a quorum-semsomg factor required for mazEF-mediated cell death in E. coli (Science, 26 Oct 2007, 318:652).
King,NeilOct 29, 2007GPCR engineering yields high-resolution structural insights into beta2 adrenergic receptor function. (Science, published online 25 Oct 2007).
Forse, JasonOct 22, 2007High-resolution structure prediction and the crystallographic phase problem (Nature, 14 Oct 2007, advance online publication).
Landau, MeytalOct 15, 2007A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice.
Ivanova,MagdalenaSep 24, 2007Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH (Nature, 20 Sept 2007, 449:316-323).
Miller, ChristopherSep 17, 2007Crystal structure of an ancient protein: evolution by conformational epistasis (Science, 14 Sept 2007, 317:1544).
Nelson, RebeccaSep 10, 2007LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake (Science, 7 Sept 2007, 317:1390).
Labor Day, no meetingSep 3, 2007A common fold mediates vertebrate defense and bacterial attack (Science, published online 23 Aug 2007).
Apostol, MarcinAug 20, 2007Structure and function of an essential component of the outer membrane protein assembly machine (Science, 17 Aug 2007, 317:961); Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily (Science, 17 Aug 2007, 317:957).
Crowley, ChristopherAug 13, 2007Global changes to the ubiqutin system in Huntington's disease Nature 448, 704-708.
Goldshmidt, LukaszAug 6, 2007A reversible wet/dry adhesive inspired by mussels and geckos (Nature, 19 July 2007, 448:338).
Li, HuiyingJul 23, 2007Conformational entropy in molecular recognition by proteins (Nature, 19 July 2007, 448:325) .
Llewellyn, RichardJul 16, 2007Postreplicative formation of cohesion is required for repair and induced by a single DNA break (Science, 13 July 2007, 317:242).
Kaufmann, MarkusJul 9, 2007Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells Science 6 July 2007.
Guo, ZhefengJul 2, 2007Development of the Human Infant Intestinal Microbiota PLoS Biol. 2007 July 26; 5(7).
Miallau, LindaJun 25, 2007Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO advance online publication 14 June 2007.
Sievers, StuartJun 18, 2007Transvascular delivery of small interfering RNA to the central nervous system (Nature AOP, 17 June 2007).
Medrano-Soto, ArturoJun 11, 2007Probing transcription factor dynamics at the single-molecule level in a living cell (Science, 25 May 2007, 316:1191).
Stroud, JamesJun 4, 2007In search of the biological significance of modular structures in protein networks (PLoS Comput. Biol., 1 Jun 2007, 3:e107).
Sawaya, MichaelMay 21, 2007Prion recognition elements govern nucleation, strain specificity and species barriers (Nature AOP, 9 May 2007).
Riley, RobertMay 14, 2007Stepwise formation of the bacterial flagellar system (PNAS, 24 Apr 2007, 104:7116).
Teng, PohMay 7, 2007Bacterial glycosidases for the production of universal red blood cells (Nat. Biotechnol., Apr 2007, 25:454).
Tanaka, ShihoApr 30, 2007Expanding the diversity of chemical protein modification allows post-translational mimicry (Nature, 26 Apr 2007, 446:1105).
Colletier, Jacques-PhilippeApr 23, 2007A toxic monomeric conformer of the polyglutamine protein (Nat. Struct. Mol. Biol., Apr 2007, 14:332).
Norcross, ToddApr 16, 2007Assessment of the probabilities for evolutionary structural changes in protein folds (Bioinformatics, advance access published 4 Feb 2007).
Miller, ChristopherApr 2, 2007CRISPR provides acquired resistance against viruses in prokaryotes (Science, 23 Mar 07, 315:1709).
Forse, JasonMar 19, 2007The crystal structure of a virus-like particle from the hyperthermophilic archaeon Pyrococcus furiosus provides insight into the evolution of viruses (JMB online, 3/5/07).
Salwinski, LukaszMar 12, 2007Structure of an ABC transporter in complex with its binding protein (Nature, 8 March 2007, 446:213).
Nelson, RebeccaFeb 12, 2007Global reconstruction of the human metabolic network based on genomic and bibliomic data (PNAS, 6 Feb 2007, 104:1777).
Sprinzak, EinatFeb 5, 20071) Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation (Nat. Biotechnol., Jan 2007, 25:117); 2) Computational prediction of proteotypic peptides for quantitative proteomics (Nat. Biotechnol., Jan 2007, 25:125) .
McFarlane, HeatherJan 29, 2007Protein and DNA sequence determinants of thermophilic adaptation (PLoS Comput. Biol., Jan 2007, 3:e5).
Goldshmidt, LukaszJan 22, 2007All-atom ab initio folding of a diverse set of proteins (Structure, 17 Jan 2007, 15:53).
Wiltzius, JedJan 8, 2007Antibacterial lysine analogs that target lysine riboswitches (Nat. Chem. Biol. 2007 Jan, 3:44).
Li, HuiyingDec 18, 2006Variability and memory of protein levels in human cells (Nature 30 Nov 2006, 444:643).
Apostol, MarcinDec 11, 2006Enzyme-free nucleic acid logic circuits (Science 8 Dec 2006, 314:1585).
Llewellyn, RichardDec 4, 2006Analyzing proteome topology and function by automated multidimensional fluorescence microscopy (Nature Biotechnology Oct 2006, 24:1270).
Kaufmann, MarkusNov 27, 2006Hot-spot mimicry of a cytokine receptor by a small molecule (PNAS 17 Oct 2006, 103:15422).
Medrano-Soto, ArturoNov 20, 2006The nature and dynamics of bacterial genomes (Science, 24 Mar 2006, 311:1730).
Stroud, JamesNov 13, 2006Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). (Nature Genetics Nov 2006, 38:1348).
Sievers, StuartNov 6, 2006Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia (Nature AOP 1 November 2006).
Guo, ZhefengOct 30, 2006Symbiosis insights through metagenomic analysis of a microbial consortium (Nature 26 Oct 2006, 443:950).
Sawaya, MichaelOct 9, 2006Reassembly of shattered chromosomes in Deinococcus radiodurans (Nature AOP 27 Sept 2006).
Teng, PohOct 2, 2006Microdiesel: Escherichia coli engineered for fuel production. (Microbiology Sept 2006, 152:2529).
Beeby, MorganSep 25, 2006Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution (JMB 6 Oct 2006, 362:1004).
Miller, ChristopherSep 18, 2006A microrotary motor powered by bacteria (PNAS 12 Sept 2006, 103:13618).
Tanaka, ShihoSep 11, 2006Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex (Nature 7 Sept 2006, 443:110).
Sambashivan, ShilpaAug 21, 2006Crystal structures of a multidrug transporter reveal a functionally rotating mechanism (Nature AOP, 16 August 2006).
Riley, RobertAug 14, 2006DNA detection using recombination proteins (PLOS Biol July 2006, 4(7):e204).
King, NeilAug 7, 2006Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions (Nat. Biotechnol. July 2006, 24:852).
Forse, JasonJul 31, 2006Protein flexibility acclimatizes photosynthetic energy conversion to the ambient temperature (Nature AOP, 23 July 2006).
Magdalena Ivanova,Jul 24, 2006Atom-by-atom analysis of global downhill protein folding (Nature 20 July 2006, 442:317).
Salwinski, LukaszJul 17, 2006Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G (Science 14 July 2006, 313:187); Crystal structure of glycoprotein B from herpes simplex virus 1 (Science 14 July 2006, 313:217).
McFarlane, HeatherJun 26, 2006Sequencing genomes from single cells by polymerase cloning (Nat Biotechnol 2006 June, 24:680).
Sprinzak, EinatJun 19, 2006Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise (Nature 15 June 2006, 441:840).
Li, HuiyingMay 8, 2006Structure of the multidrug transporter EmrD from Escherichia coli (Science 5 May 2006, 312:741).
Apostol, MarcinMay 1, 2006Probing the conformation of the prion protein within a single amyloid fibril using a novel immunoconformational assay (J Biol Chem, published online ahead of print March 27, 2006, 10.1074/jbc.M601349200).
O'Connor, BrianApr 24, 2006Deciphering the evolution and metaboism of an anammox bacterium from a community genome (Nature 6 Apr 2006, 440:790).
Boutz, DanielApr 17, 2006Protein stability promotes evolvability (PNAS 11 April 2006, 103: 5869) .
Bowers, PeterApr 10, 2006.
Kaufmann, MarkusApr 3, 2006High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes (PNAS 28 March 2006, 103:4841).
Stroud, JamesMar 20, 2006A specific amyloid-beta protein asembly in the brain impairs memory..
Guo, ZhefengMar 6, 2006Genome-wide Detection of Polymorphisms at Nucleotide Resolution with a Single DNA Microarray.
Banatao, Diosdado ReyFeb 13, 2006Identification of protein domains by shotgun proteolysis (JMB in press: doi:10.1016/j.jmb.2006.01.057) .
Sawaya, MichaelFeb 6, 2006Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus (Nature 2006 Feb 2, 439:612).
Medrano-Soto, ArturoJan 30, 2006Adaptive evolution of bacterial metabolic networks by horizontal gene transfer (Nature Genetics 2005 Dec, 37:1372).
Beeby, MorganJan 23, 2006The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites (Cell 13 Jan 2006, 124:61).
Teng, PohJan 9, 2006.
Salwinski, LukaszNov 28, 2005Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gamma-c receptors.
Sprinzak, EinatNov 14, 2005Oncogenic pathway signatures in human cancers as a guide to targeted therapies (Nature AOP, 6 Nov 2005).
Wiltzius, JedOct 10, 2005Oncogenic pathway signatures in human cancers as a guide to targeted therapies (Nature AOP, 6 Nov 2005).
Goldshmidt, LukaszOct 3, 2005Crystallographic refinement by knowledge-based exploration of complex energy landscapes (Structure Sept 2005, 13:1311).
Norcross, ToddSep 26, 2005Using information theory to search for co-evolving residues in proteins (Bioinformatics, advance access 13 Sept 2005).
Labor Day, no meetingSep 5, 2005A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT. Science, Vol 309, Issue 5740, 1570-1573.
Bowers, PeterAug 15, 2005Structural basis for the activation of cholera toxin by human ARF6-GTP (Science 12 Aug 2005, 309:1093) .
Chaudhuri, BarnaliAug 8, 2005Global rigid body modeling of macromolecular complexes against small-angle scattering data. (Biophys. J. 2005, 89:1237) .
Tsai, YingssuAug 1, 2005Barker D, Pagel M (2005) Predicting Functional Gene Links from Phylogenetic-Statistical Analyses of Whole Genomes. PLoS Comp Biol 1(1): e3.
Stroud, JamesJul 25, 2005Multiplexed detection of pathogen DNA with DNA-based fluorescence nanobarcodes (Nat. Biotechnol. Jul 2005, 23:885).
Guo, ZhefengJul 18, 2005Amyloid ion channels: A common structural link for protein-misfolding disease. Proc Natl Acad Sci U S A. 2005 Jul 14.
Thompson, MichaelJul 11, 2005X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Schalch T, Duda S, Sargent DF, Richmond TJ. Nature. 2005 Jul 7;436(7047):138-41..
Li, HuiyingMay 23, 2005Systematic interpretation of genetic interactions using protein networks (Nature Biotech. May 2005, 23:561).
Banatao, ReyMay 16, 2005Programmable DNA self-assemblies for nanoscale organization of ligands and proteins. (Nano Lett. Apr 2005, 5:729).
Beeby, MorganMay 9, 2005Computational thermostabilization of an enzyme. (Science 6 May 2005, 308:857).
Kim, Sul-MinMay 2, 2005Identification of a Multicomponent Complex required for Outer Membrane Biogenesis in E. Coli.
Laidman, JanelApr 25, 2005The GB1 Amyloid Fibril: Recruitment of the Peripheral beta-Strands of the Domain Swapped Dimer into the Polymeric Interface.
Ivanova, MagdalenaApr 11, 2005Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins (Cell 8 April 2005, 121:49).
Norcross, ToddApr 4, 2005Protein homology detection by HMM?HMM comparison (Bioinformatics 1 Apr 2005, 21:951).
Nelson, RebeccaMar 28, 2005Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex (Science 18 March 2005, 307:1776).
Salwinski, LukaszMar 14, 2005Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis. Nature. 2005 Mar 24;434(7032):505-9. .
Riley, RobertMar 7, 2005Computational verification of protein-protein interactions by orthologous co-expression. (BMC Bioinformatics 2 Mar 2005, 6:40).
Strong, MichaelFeb 28, 2005Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals (Nature, published online 27 Feb 2005).
Sprinzak, EinatFeb 14, 2005Highly conserved non-coding sequences are associated with vertebrate development. Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, Vavouri T, Smith SF, North P, Callaway H, Kelly K, Walter K, Abnizova I, Gilks W, Edwards YJ, Cooke JE, Elgar G. PLoS Biol. 2005 Jan;3(1):e7. Epub 2004 Nov 11..
Kaufmann, MarkusJan 24, 2005Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils (Science 14 Jan 2005, 307:262).
Boutz, DanielJan 10, 2005Molecular basis for amyloid fibril formation and stability (PNAS 11 Jan 2005, 102:315).
Chaudhuri, BarnaliJan 3, 2005"Complementarity of Structure Ensembles in Protein-Protein Binding" Raik Gr?nberg1, Johan Leckner1, 2 and Michael Nilges Structure Volume 12, Issue 12 , December 2004, Pages 2125-2136 .
Stroud, JamesDec 13, 2004Mitochondrial fission proteins regulate programmed cell death in yeast (Genes Dev. 15 Nov 2004, 18:2785).
Guo, ZhefengDec 6, 2004Human prion protein with valine 129 prevents expression of variant CJD phenotype. Science, 2004, 306:1793-1796. Wadsworth JD, Asante EA, Desbruslais M, Linehan JM, Joiner S, Gowland I, Welch J, Stone L, Lloyd SE, Hill AF, Brandner S, Collinge J..
Michael Thompson,Nov 29, 2004A Domain Interaction Map Based on Phylogenetic Profiling. Pagel P, Wong P, Frishman D. J Mol Biol. 2004 Dec 10;344(5):1331-1346..
Sievers, StuartNov 22, 2004Conservation of Orientation and Sequence in Protein Domain-Domain Interactions. Stephen J. Littler and Simon J. Hubbard Journal of Molecular Biology doi:10.1016/j.jmb.2004.11.011 .
Tsai, YingssuNov 15, 2004Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks Singleton et al. Nature vol 432, 187-193.
Sawaya, MichaelNov 8, 2004Origin of icosahedral symmetry in viruses (PNAS 2 Nov 2004, 101:15556).
Llewellyn, RichardNov 1, 2004Macrodomain Organization of the E.coli Chromosome. Mich?le Valens, St?phanie Penaud, Mich?le Rossignol, Fran?ois Cornet, and Fr?d?ric Boccard . EMBO J. 2004 23: 4330-4341 .
Li, HuiyingOct 25, 2004A glycine-dependent riboswitch that uses cooperative binding to control gene expression (Science 8 Oct 2004, 306:275).
Beeby, MorganOct 18, 2004The site specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination (Nature Biotechnol. Oct 2004, 22(10):1297)..
Kim, Sul-MinOct 11, 2004The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics (Nat. Struct. Mol. Biol. 2004, 11:963).
Laidman, JanelOct 4, 2004"Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins" Nature 431 590-96.
Bowers, PeterSep 27, 2004Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins (Nat. Biotechnol. 12 Sept 2004 - epub ahead of print).
Miller, ChristopherSep 20, 2004Genomic analysis of regulatory network dynamics reveals large topological changes. (Nature 16 Sept 2004, 431:308).
Norcross, ToddSep 13, 2004The ring of life provides evidence for a genome fusion origin of eukaryotes. Rivera MC, Lake JA. Nature. 2004 Sep 9;431(7005):152-5. .
Labor Day, no meetingSep 6, 2004Crystal Structure of Argonaute and Its Implications for RISC Slicer. Science 3 September 2004: 1434-1437..
Sambashivan, ShilpaAug 23, 2004Autocatalytic self-propagation of misfolded prion protein (PNAS 17 Aug 2004, 101:12207).
Nelson, RebeccaAug 16, 2004Genetic analysis of genome-wide variation in human gene expression (Nature 12 Aug 2004, 430:743).
Riley, RobertAug 9, 2004Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Xiong Y, Steitz TA. Nature. 2004 Aug 5;430(7000):640-5. and Structural basis for template-independent RNA polymerization. Tomita K, Fukai S, Ishitani R, Ueda T, Takeuchi N, Vassylyev DG, Nureki O. Nature. 2004 Aug 5;430(7000):700-4. .
Grothe, RobAug 2, 2004Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment. Ramachandran R, Tweten RK, Johnson AE. Nat Struct Mol Biol. 2004 Aug;11(8):697-705. Epub 2004 Jul 04..
Strong, MichaelJul 26, 2004.
Han, YunJul 19, 2004Inactive enzyme-homologues find new function in regulatory processes. Pils B, Schultz J. J Mol Biol. 2004 Jul 9;340(3):399-404. .
OConnor,BrianJul 12, 2004Evidence for dynamically organized modularity in the yeast protein-protein interaction network (Nature 1 Jul 2004, 430:88).
Apostol, MarcinJun 28, 2004Computational design of a biologically active enzyme (Science 25 June 2004, 304:1967).
Kaufmann, MarkusJun 21, 2004Walburger A, Koul A, Ferrari G, Nguyen L, Prescianotto-Baschong C, Huygen K, Klebl B, Thompson C, Bacher G, Pieters J. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4. Epub 2004 May 20..
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Ryttersgaard, CarstenAug 26, 2002To be announced.
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Mallick, ParagJul 8, 2002TRILOGY: Discovery of sequence-structure patterns across diverse proteins (PNAS 2002, 99:8500).
Goulding, CeliaJul 1, 2002All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade (PNAS 2002, 99:8506).
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Graeber, TomApr 8, 20021. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases (Nature 2002, 416:507), 2. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo (Nature 2002, 416:535).
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Kleiger, GaryMar 4, 2002Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21 (Science 2001, 294:1719) .
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Ryttersgaard, CarstenFeb 11, 2002The genome sequence of Schizosaccharomyces pombe (Nature 2002, 415:871).
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Kleiger, GaryNov 19, 2001A molecular movie at 1.8A resolution displays the photocycle of photoactive yellow protein, a eubacterial blue-light receptor, from nanoseconds to seconds (Biochemistry 2001, 40:13788).
Lee, SanghoNov 5, 2001POTASSIUM CHANNEL IN ACTION: 1.See potassium run (Nature 2001, 414:23), 2.Energetic optimization of ion conduction rate by K+ selectivity filter (Nature 2001, 414:37), 3.Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0A resolution (Nature 2001, 414:43), 4.Energetics of ion conduction through the K+ channel (Nature 2001:414:73).
Mallick, ParagOct 29, 2001PROTEIN DYNAMICS w/ X-RAY & NMR: 1a) Slick switching of X-rays (Nature 2001, 413:784), 1b) Coherent control of pulsed X-ray beams (Nature 2001, 413:825); 2a) Protein dynamic studies move to a new time slot (Nat. Struct. Biol. 2001, 8:912), 2b) Studying excited states of proteins by NMR spectroscopy (Nat. Struct. Biol. 2001, 8:932), 2c) Dynamic activation of protein function: a view emerging from NMR spectroscopy (Nat. Struct. Biol. 2001, 8:926), 2d) An open and shut case (Nat. Struct. Biol. 2001, 8:910).
Pfluegl, GastonOct 22, 20011. Combined EM/X-Ray Imaging Yields a Quasi-Atomic Model of the Adenovirus-Related Bacteriophage PRD1 and Shows Key Capsid and Membrane Interactions (Structure 2001, 9:917) 2. Using electron-microscopy images as a model for molecular replacement (Acta Cryst 2001, D57:1405) *Entire October issue of Acta Cryst D deals w/ EM.
Xenarios, IoannisOct 15, 2001Crystal structure of the extracellular segment of integrin alphaVbeta3 (Science 2001, 294:339).
Chaudhuri, BarnaliOct 8, 2001.
Sawaya,MichaelOct 1, 2001.
Li, HuiyingSep 24, 2001.
Sean Lott of TB Consortium,Sep 17, 2001.
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Strong, MichaelAug 27, 2001.
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Xiaoqun Joyce,DuanJun 11, 2001.
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Pfluegl,GastonApr 16, 2001.
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