| Presenter | Date | Title |
|---|
| Anni Zhao | Feb 13th, 2012 | Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory. Cell. 2012 Feb 3;148(3):515-29.. |
| Jiyong Park | Jan 30th, 2012 | Mechanisms of protein oligomerization: Inhibitor of functional amyloids templates a-synuclein fibrilla-tion. J Am Chem Soc. 2012 Jan 19. [Epub ahead of print]. |
| Jung Reem Woo | Dec 12th, 2011 | Functional links between aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science. 2011 Dec 2;334(6060):1241-5. . |
| Boris Brumshtein | Nov 28th, 2011 | Temperature-scan cryocrystallography reveals reaction intermediates in bacteriophytochrome. Nature. 2011 Oct 16;479(7373):428-32 . |
| Linda Miallau | Oct 3rd, 2011 | Structure of the Adenosine A(2A) Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine. Structure. 2011 Sep 7;19(9):1283-93.. |
| Dan Li | Sep 19th, 2011 | A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme. Cell. 2011 Sep 2;146(5):732-45.. |
| Michael Thompson | Aug 29th, 2011 | Generation of protein lattices by fusing proteins with matching rotational symmetry. Nat Nanotechnol. 2011. |
| Natalie Anderson | Aug 22nd, 2011 | Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. NATURE | VOL 476 | 11 AUGUST 2011. |
| Nicole Wheatley | Aug 8th, 2011 | Quantitation of protein–protein interactions by thermal stability shift analysis. Protein Science 20(8) 2011 . |
| Lin Jiang | Aug 1st, 2011 | Sequence and Structural Convergence of Broad and Potent HIV Antibodies. Science. 2011 Jul 14. [Epub ahead of print] That Mimic CD4 Binding. . |
| Andrew Min | Jul 25th, 2011 | A two-step chemical mechanism for ribosome-catalysed peptide bond formation. Nature. 2011 Jul 17. doi: 10.1038/nature10248. [Epub ahead of print]. |
| Stuart Sievers | Jul 18th, 2011 | Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP. Nature. 2011 Jul 6 [Epub ahead of print]. |
| Meytal Landau | Jun 27th, 2011 | Latent TGF-β structure and activation. Nature. 16 June 2011; 474:343–349. |
| Fang Sheng | Jun 20th, 2011 | A bacterium that can grow by using arsenic instead of phosphorus. Science. 2011 Jun 3;332(6034):1163-6. . |
| Riki Stevenson | Jun 13th, 2011 | Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nat Struct Mol Biol. 2011 Jun;18(6):693-700. |
| Minglei Zhao | May 23rd, 2011 | Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin. Science 13 May 2011: Vol. 332 no. 6031 pp. 816-821 . |
| Heather McFarlane | May 16th, 2011 | Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å. Nature 473: 55–60 (05 May 2011). |
| Jiyong Park | May 9th, 2011 | Natural tri- to hexapeptides self-assemble in water to amyloid beta-type fiber aggregates by unexpected alpha-helical intermediate structures. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.. |
| Howard Chang | May 2nd, 2011 | A universal method for detection of amyloidogenic misfolded proteins. Biochemistry, Just Accepted Manuscript. |
| Michael Sawaya | Apr 25th, 2011 | Femtosecond X-ray protein nanocrystallography.. |
| Angela Soriaga | Apr 18th, 2011 | Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. |
| Boris Brumshtein | Apr 11th, 2011 | Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.. |
| Linda Miallau | Mar 21st, 2011 | Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.. |
| Cong Liu | Mar 14th, 2011 | Genetic selection designed to stabilize proteins uncovers a chaperone called Spy. |
| Arthur Laganowsky | Mar 7th, 2011 | Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. |
| Sophia Tsai | Feb 21st, 2011 | Development of an artificial cell, from self- organization to computation and self-reproduction. |
| Dan Li | Feb 14th, 2011 | Directed evolution of a protein container.. |
| Angela Soriaga | Feb 7th, 2011 | X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.. |
| Heather McFarlane | Oct 11th, 2010 | An unprecedented nucleic acid capture mechanism for excision of DNA damage. Nature 2010. |
| Minglei Zhao | Oct 4th, 2010 | Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers. Nat Struct Mol Biol. 2010 Sep;17(9):1037-42.. |
| Arturo Medrano-Soto | Sep 27th, 2010 | Predicting protein-protein interactions in the context of protein evolution. Mol Biosyst. 2010 Jan;6(1):55-64. . |
| Jiyong Park | Sep 20th, 2010 | Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 2010 Sep9; 467 (7312): 179-84. |
| James Stroud | Sep 6th, 2010 | Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks. Science. 2010 Aug 27;329(5995):1038-43.. |
| Anni Zhao | Aug 30th, 2010 | Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans. PLoS Biol. 2010 Aug 10;8(8).. |
| Michael Sawaya | Aug 23rd, 2010 | Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01. Science. 2010 Aug 13;329(5993):811-7. . |
| Boris Brumshtein | Aug 16th, 2010 | Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature. 2010 Aug 5;466(7307):774-8.. |
| Lukasz Salwinski | Jul 26th, 2010 | An analytical solution to the kinetics of breakable filament assembly. Science. 2009 Dec 11;326(5959):1533-7.. |
| Meytal Landau | Jul 19th, 2010 | Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity. Cell 9 July 2010, 142(1): 101-111 . |
| Cong Liu | Jun 28th, 2010 | Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol. 2010 Jun 13. . |
| Dan Li | May 24th, 2010 | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay. Nature. 2010 May 13;465(7295):236-8.. |
| Marcin Apostol | May 17th, 2010 | D-amino acids trigger biofilm disassembly Science. 2010 Apr 30;328(5978):627-9.. |
| Jason Forse | May 10th, 2010 | Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science. 2010 Apr 23;328(5977):470-3.. |
| Magdalena Ivanova | May 3rd, 2010 | Super-resolution biomolecular crystallography with low-resolution data.Nature. 2010 Apr 22;464(7292):1218-22. . |
| Nina Ram | Apr 26th, 2010 | Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature. 2010 Jan 28;463(7280):549-53.. |
| Michael Thompson | Apr 19th, 2010 | The structural basis of peptide-protein binding strategies. Structure. 2010 Feb 10;18(2):188-99.. |
| Lin Jiang | Apr 12th, 2010 | The structural basis of peptide-protein binding strategies. Structure. 2010 Feb 10;18(2):188-99.. |
| Fang Sheng | Mar 29th, 2010 | ttttttttttttttttttttttt. |
| Tobias Sayre | Mar 22nd, 2010 | Spatially Ordered Dynamics of the Bacterial Carbon Fixation Machinery. Science, 5 March 2010, 1258-1261.. |
| Lukasz Goldschmidt | Mar 15th, 2010 | Spatially Ordered Dynamics of the Bacterial Carbon Fixation Machinery. Science, 5 March 2010, 1258-1261.. |
| Einat Sprinzak | Mar 8th, 2010 | Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli. PLoS Biol. 2010 Feb 23;8(2):e1000317. . |
| Heather McFarlane | Mar 1st, 2010 | Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature advance online publication 14 February 2010. |
| Minglei Zhao | Feb 22nd, 2010 | Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation. Cell, Volume 140, Issue 3, 421-435, 5 February 2010. |
| James Stroud | Jan 11th, 2010 | Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature 462, 762-766 2009. |
| Anni Zhao | Dec 14th, 2009 | Structural properties of pore-forming oligomers of alpha-synuclein.. |
| Angela Soriaga | Dec 7th, 2009 | Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009 Nov 22. [Epub ahead of print]. |
| Neil King | Nov 23rd, 2009 | Direct inhibition of the NOTCH transcription factor complex. Nature. 2009 Nov 12;462(7270):182-8.. |
| Howard Chang | Nov 16th, 2009 | Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift. Science 30 October 2009: Vol. 326. no. 5953, pp. 734 - 736. |
| Christopher Crowley | Nov 9th, 2009 | Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009 Oct 29;461(7268):1282-6.. |
| Shiho Tanaka | Nov 2nd, 2009 | The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA. Science. 2009 Oct 15. [Epub ahead of print]. |
| Lukasz Salwinski | Oct 26th, 2009 | Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15;461(7266):997-1001.. |
| Linda Miallau | Oct 19th, 2009 | Gene therapy for red-green colour blindness in adult primates. ature. 2009 Sep 16. [Epub ahead of print]. |
| Meytal Landau | Oct 5th, 2009 | Positive Selection of Tyrosine Loss in Metazoan Evolution. Science 25 September 2009: Vol. 325. no. 5948, pp. 1686 - 1688. |
| Cong Liu | Sep 28th, 2009 | Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nat Struct Mol Biol. 2009 Sep 13. [Epub ahead of print]. |
| Arthur Laganowsky | Sep 21st, 2009 | Promiscuous Substrate Recognition in Folding and Assembly Activities of the Trigger Factor Chaperone. Cell, Volume 138, Issue 5, 923-934, 4 September 2009 . |
| Dan Li | Sep 14th, 2009 | Myosin VI undergoes cargo-mediated dimerization. Cell. 2009 Aug 7;138(3):537-48.. |
| Marcin Apostol | Aug 31st, 2009 | Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science 2009 Aug 21;325(5943):966-70.. |
| Richard Llewellyn | Aug 24th, 2009 | The Secret Life of the Anthrax Agent Bacillus anthracis: Bacteriophage-Mediated Ecological Adaptations. PLoS One. 2009 Aug 12;4 (8) :e6532. |
| Jason Forse | Aug 17th, 2009 | Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nature Structural & Molecular Biology 16, 890 - 896 (2009) . |
| Stuart Sievers | Aug 10th, 2009 | Synthetic protein scaffolds provide modular control over metabolic flux. Nature Biotechnology Published online: 2 August 2009. |
| Magdalena Ivanova | Aug 3rd, 2009 | Helical extension of the neuronal SNARE complex into the membrane. Nature 460, 525-528 2009 . |
| Lukasz Goldschmidt | Jul 27th, 2009 | Motif-directed flexible backbone design of functional interactions. Protein Sci. 2009 Jun;18(6):1293-305.. |
| Stuart Sievers | Jul 20th, 2009 | structure of a prokaryotic virtual proton pump at 3.2 angstrom resolution. Nature advance online publication 5 july 2009. |
| Arturo Medrano-Soto | Jun 29th, 2009 | X-Ray Structures of the Hexameric Building Block of the HIV Capsid. |
| Minglei Zhao | Jun 29th, 2009 | Diversity and Complexity in DNA Recognition by Transcription Factors. Science Epub ahead of print. |
| Poh Teng | Jun 8th, 2009 | Fabricating genetically engineered high-power lithium-ion batteries using multiple virus genes. Science. 2009 May 22;324(5930):1051-5. . |
| Jiyong Park | May 25th, 2009 | Branching in amyloid fibril growth. Biophys J. 2009 Feb 18;96(4):1529-36.. |
| Yingssu Tsai | May 18th, 2009 | Structural studies of the giant mimivirus. PLoS Biol. 2009 Apr 28;7(4):e92.. |
| James Stroud | May 11th, 2009 | A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell 2009 Apr 17;137(2):308-20.. |
| Anni Zhao | May 4th, 2009 | Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism. Nature Structural & Molecular Biology 16, 380 - 389 (2009) . |
| Angela Soriaga | Apr 20th, 2009 | Coding-sequence determinants of gene expression in Escherichia coli. Science 2009 Apr 10;324(5924):255-8.. |
| Michael Sawaya | Apr 13th, 2009 | Structure of the connexin 26 gap junction channel at 3.5 A resolution. Nature 2009. |
| Howard Chang | Mar 30th, 2009 | Design and engineering of an O(2) transport protein. Nature 2009 Mar 19;458(7236):305-9.. |
| Cong Liu | Mar 23rd, 2009 | Interprotofilament interactions between Alzheimer's A{beta}1-42 peptides in amyloid fibrils revealed by cryoEM. PNAS 2009 Mar 5. [Epub ahead of print]. |
| Shiho Tanaka | Mar 16th, 2009 | Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. PNAS 2009 Mar 3;106(9):3059-64. . |
| Lukasz Salwinski | Mar 9th, 2009 | A hierarchical model for evolution of 23S ribosomal RNA. Nature 2009 457(7232):977-80. . |
| Christopher Crowley | Mar 2nd, 2009 | Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature 2009 Feb 1. [Epub ahead of print]. |
| Dan Li | Feb 9th, 2009 | Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB. Science Vol. 323. no. 5912, pp. 396 - 401. |
| Jason Forse | Jan 12th, 2009 | Quality control by the ribosome following peptide bond formation. Nature 457, 161-166 (8 January 2009). |
| Richard Llewellyn | Jan 5th, 2009 | Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity. Cell, Volume 135, Issue 6, 12 December 2008, Pages 1085-1097 . |
| Richard Llewellyn | Dec 22nd, 2008 | Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity. Cell, Volume 135, Issue 6, 12 December 2008, Pages 1085-1097 . |
| Magdalena Ivanova | Dec 15th, 2008 | Initiation and elongation in fibrillation of ALS-linked superoxide dismutase. PNAS December 2, 2008 vol. 105 . |
| Heather McFarlane | Dec 8th, 2008 | Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils. PNAS 2008 105:18349-18354. |
| Markus Kaufmann | Dec 1st, 2008 | The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist. Science 322 no. 5905, pp. 1211 - 1217 2008 . |
| Jiyong Park | Nov 24th, 2008 | A Molecular Dynamics Study of the Interaction of d-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation. J Mol Biol. 2008 Oct
31;383(1):266-80 . |
| Lukasz Goldschmidt | Nov 17th, 2008 | Fragment-HMM: A new approach to protein structure prediction. Protein Science (2008), 17:1925-1934. . |
| Stuart Sievers | Nov 10th, 2008 | Interactions between Hsp70 and the Hydrophobic Core of alpha-Synuclein Inhibit Fibril Assembly. ASAP Biochemistry. Web Release Date: November 1, 2008 . |
| Einat Sprinzak | Nov 3rd, 2008 | Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy. Science 2008 Oct 9. [Epub ahead of print]
Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy. Science 2008 . |
| Minglei Zhao | Oct 27th, 2008 | Surface sites for engineering allosteric control in proteins. Science. 2008 Oct 17;322(5900):438-42.. |
| Angela Soriaga | Oct 20th, 2008 | Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines (PNAS, 7 Oct 2008, 105:15334). |
| Arturo Medrano-Soto | Oct 13th, 2008 | Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies (PLoS Comput. Biol, 1 Aug 2008, 4:e1000142). |
| Anni Zhao | Oct 6th, 2008 | A regulatable switch mediates self-association in an immunoglobulin fold (NSMB, Sept. 2008, 15:965). |
| Jed Wiltzius | Sep 29th, 2008 | Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield (PNAS, 16 Sept 2008, 105:13769). |
| Arthur Laganowsky | Sep 22nd, 2008 | Chemical and biological approaches synergize to ameliorate protein-folding diseases (Cell, 5 Sept 2008, 134:769) . |
| Yingssu Tsai | Sep 8th, 2008 | Evolutionary ecology of pungency in wild chilies (PNAS, 19 Aug 2008, 105:11808). |
| James Stroud | Aug 25th, 2008 | Secreted transcription factor controls Mycobacterium tuberculosis virulence (Nature, 7 Aug 2008, 454:717). |
| James Stroud | Aug 18th, 2008 | Secreted transcription factor controls Mycobacterium tuberculosis virulence (Nature, 7 Aug 2008, 454:717). |
| Michael Sawaya | Aug 11th, 2008 | Crystal structure of the termination module of a nonribosomal peptide synthetase (Science, 1 Aug 2008, 321:659). |
| Shiho Tanaka | Aug 4th, 2008 | 1. Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU (Nature, AOP 23 July 2008); 2.enterohaemorrhagic E. coli effector EspFU (Nature, AOP 23 July 2008); 2. The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency (Nature, AOP 23 July 2008) . |
| Howard Chang | Jul 28th, 2008 | Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT (Nat. Struct. Molec. Biol., July 2008, 15:746). |
| Neil King | Jul 21st, 2008 | Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor (Nature, 10 July 2008, 454:177). |
| Meytal Landau | Jul 14th, 2008 | Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease (JBC, 4 July 2008, 283:19058). |
| Lukasz Salwinski | Jul 7th, 2008 | Functional maps of protein complexes from quantitative genetic interaction data (PLoS Comput. Biol., April 2008, 4(4):e1000065). |
| Christopher Crowley | Jun 30th, 2008 | Assembly reflects evolution of protein complexes (Nature, Advance Online Publication, 18 June 2008). |
| Marcin Apostol | Jun 23rd, 2008 | Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution (Science, 13 June 2008, 320: 1471). |
| Christopher Miller | Jun 16th, 2008 | Predictive behavior within microbial genetic networks (Science, 6 June 2008, 320:1313). |
| Jason Forse | Jun 9th, 2008 | Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins (PNAS, 3 June 2008, 105:7702); Structural basis for the regulated protease and chaperone function of DegP (Nature, advance online publication 21 May 2008). |
| Magdalena Ivanova | May 19th, 2008 | Genome analysis of the platypus reveals unique signatures of evolution (Nature, 8 May 2008, 453:175). |
| Heather McFarlane | May 12th, 2008 | Design of protein function leaps by directed domain interface evolution (PNAS, 6 May 2008, 105(18): 6578). |
| Lukasz Goldschmidt | May 5th, 2008 | Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane (PNAS, 22 April 2008, 105(16): 6033). |
| Markus Kaufmann | Apr 28th, 2008 | Bacteria subsisting on antibiotics (Science 4 April 2008: 100-103). |
| Linda Miallau | Apr 21st, 2008 | Opening and closing of the periplasmic gate in lactose permease (PNAS, 11 Mar 2008, 105:3774-8). |
| Toni Lee | Apr 7th, 2008 | Kemp elimination catalysts by computational enzyme design (Nature, advance online publication 19 March 2008). |
| Richard Llewellyn | Mar 31st, 2008 | Two Seemingly Homologous Noncoding RNAs Act Hierarchically to Activate glmS mRNA Translation (PLoS Biology, March 2008, 6(3): e6). |
| Einat Sprinzak | Mar 17th, 2008 | Intrinsically disordered proteins display no preference for chaperone binding in vivo. (PLoS Comp. Biol. Feb 2008). |
| Minglei Zhao | Mar 10th, 2008 | A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing (Nature, 6 Mar 2008, 452:108). |
| Arturo Medrano-Soto | Mar 3rd, 2008 | Genome-wide experimental determination of barriers to horizontal gene transfer (Science, 30 Nov 2007, 318:1449). |
| Arthur Laganowsky | Feb 25th, 2008 | Structural basis for the function and inhibition of an influenza virus proton channel (Nature, 31 Jan 2008, 451:596), Structure and mechanism of the M2 proton channel of influenza A virus (Nature, 31 Jan 2008, 451:591). |
| Yingssu Tsai | Feb 4th, 2008 | Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages (PNAS, 22 Jan 2008, 105:1009). |
| Jed Wiltzius | Jan 28th, 2008 | Designed protein-protein association (Science, 11 Jan 2008, 319:206). |
| James Stroud | Jan 14th, 2008 | Host genome surveillance for retrotransposons by transposon-derived proteins (Nature, 19 Dec 2007, epub ahead of print). |
| Michael Sawaya | Jan 7th, 2008 | Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin (Science, 2007 Dec 6, epub ahead of print). |
| Poh Teng | Dec 17th, 2007 | Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion (PLoS ONE, 2007 Oct 24, 2:e1082). |
| Jacques-Philippe Colletier | Dec 3rd, 2007 | A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. |
| Neil King | Nov 5th, 2007 | GPCR engineering yields high-resolution structural insights into beta2 adrenergic receptor function. (Science, published online 25 Oct 2007). |
| Jason Forse | Oct 29th, 2007 | High-resolution structure prediction and the crystallographic phase problem (Nature, 14 Oct 2007, advance online publication). |
| Meytal Landau | Oct 22nd, 2007 | A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice. |
| Magdalena Ivanova | Oct 1st, 2007 | Structure of acid-sensing ion channel 1 at 1.9 Ã… resolution and low pH (Nature, 20 Sept 2007, 449:316-323). |
| Christopher Miller | Sep 24th, 2007 | Crystal structure of an ancient protein: evolution by conformational epistasis (Science, 14 Sept 2007, 317:1544). |
| Rebecca Nelson | Sep 17th, 2007 | LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake (Science, 7 Sept 2007, 317:1390). |
| Marcin Apostol | Aug 27th, 2007 | Structure and function of an essential component of the outer membrane protein assembly machine (Science, 17 Aug 2007, 317:961); Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily (Science, 17 Aug 2007, 317:957). |
| Christopher Crowley | Aug 20th, 2007 | Global changes to the ubiqutin system in Huntington's disease Nature 448, 704-708. |
| Lukasz Goldschmidt | Aug 13th, 2007 | A reversible wet/dry adhesive inspired by mussels and geckos (Nature, 19 July 2007, 448:338). |
| Huiying Li | Aug 6th, 2007 | Conformational entropy in molecular recognition by proteins (Nature, 19 July 2007, 448:325) . |
| Richard Llewellyn | Jul 23rd, 2007 | Postreplicative formation of cohesion is required for repair and induced by a single DNA break (Science, 13 July 2007, 317:242). |
| Markus Kaufmann | Jul 16th, 2007 | Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells Science 6 July 2007. |
| Howard Chang | Jul 9th, 2007 | Development of the Human Infant Intestinal Microbiota PLoS Biol. 2007 July 26; 5(7). |
| Linda Miallau | Jul 2nd, 2007 | Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO advance online publication 14 June 2007. |
| Stuart Sievers | Jun 25th, 2007 | Transvascular delivery of small interfering RNA to the central nervous system (Nature AOP, 17 June 2007). |
| Arturo Medrano-Soto | Jun 18th, 2007 | Probing transcription factor dynamics at the single-molecule level in a living cell (Science, 25 May 2007, 316:1191). |
| James Stroud | Jun 11th, 2007 | In search of the biological significance of modular structures in protein networks (PLoS Comput. Biol., 1 Jun 2007, 3:e107). |
| Michael Sawaya | May 28th, 2007 | Prion recognition elements govern nucleation, strain specificity and species barriers (Nature AOP, 9 May 2007). |
| Poh Teng | May 14th, 2007 | Bacterial glycosidases for the production of universal red blood cells (Nat. Biotechnol., Apr 2007, 25:454). |
| Shiho Tanaka | May 7th, 2007 | Expanding the diversity of chemical protein modification allows post-translational mimicry (Nature, 26 Apr 2007, 446:1105). |
| Jacques-Philippe Colletier | Apr 30th, 2007 | A toxic monomeric conformer of the polyglutamine protein (Nat. Struct. Mol. Biol., Apr 2007, 14:332). |
| Christopher Miller | Apr 9th, 2007 | CRISPR provides acquired resistance against viruses in prokaryotes (Science, 23 Mar 07, 315:1709). |
| Jason Forse | Mar 26th, 2007 | The crystal structure of a virus-like particle from the hyperthermohilic archaeon Pyrococcus furiosus provides insight into the evolution of viruses (JMB online, 3/5/07). |
| Lukasz Salwinski | Mar 19th, 2007 | Structure of an ABC transporter in complex with its binding protein (Nature, 8 March 2007, 446:213). |
| Rebecca Nelson | Feb 26th, 2007 | Global reconstruction of the human metabolic network based on genomic and bibliomic data (PNAS, 6 Feb 2007, 104:1777). |
| Einat Sprinzak | Feb 12th, 2007 | 1) Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation (Nat. Biotechnol., Jan 2007, 25:117); 2) Computational prediction of proteotypic peptides for quantitative proteomics (Nat. Biotechnol., Jan 2007, 25:125) . |
| Heather McFarlane | Feb 5th, 2007 | Protein and DNA sequence determinants of thermophilic adaptation (PLoS Comput. Biol., Jan 2007, 3:e5). |
| Lukasz Goldschmidt | Jan 29th, 2007 | All-atom ab initio folding of a diverse set of proteins (Structure, 17 Jan 2007, 15:53). |
| Jed Wiltzius | Jan 22nd, 2007 | Antibacterial lysine analogs that target lysine riboswitches (Nat. Chem. Biol. 2007 Jan, 3:44). |
| Huiying Li | Jan 8th, 2007 | Variability and memory of protein levels in human cells (Nature 30 Nov 2006, 444:643). |
| Marcin Apostol | Dec 18th, 2006 | Enzyme-free nucleic acid logic circuits (Science 8 Dec 2006, 314:1585). |
| Richard Llewellyn | Dec 11th, 2006 | Analyzing proteome topology and function by automated multidimensional fluorescence microscopy (Nature Biotechnology Oct 2006, 24:1270). |
| Markus Kaufmann | Dec 4th, 2006 | Hot-spot mimicry of a cytokine receptor by a small molecule (PNAS 17 Oct 2006, 103:15422). |
| Arturo Medrano-Soto | Nov 27th, 2006 | The nature and dynamics of bacterial genomes (Science, 24 Mar 2006, 311:1730). |
| James Stroud | Nov 20th, 2006 | Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). (Nature Genetics Nov 2006, 38:1348). |
| Stuart Sievers | Nov 13th, 2006 | Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia (Nature AOP 1 November 2006). |
| Howard Chang | Nov 6th, 2006 | Symbiosis insights through metagenomic analysis of a microbial consortium (Nature 26 Oct 2006, 443:950). |
| Michael Sawaya | Oct 16th, 2006 | Reassembly of shattered chromosomes in Deinococcus radiodurans (Nature AOP 27 Sept 2006). |
| Poh Teng | Oct 9th, 2006 | Microdiesel: Escherichia coli engineered for fuel production. (Microbiology Sept 2006, 152:2529). |
| Morgan Beeby | Oct 2nd, 2006 | Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution (JMB 6 Oct 2006, 362:1004). |
| Christopher Miller | Sep 25th, 2006 | A microrotary motor powered by bacteria (PNAS 12 Sept 2006, 103:13618). |
| Shiho Tanaka | Sep 18th, 2006 | Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex (Nature 7 Sept 2006, 443:110). |
| Neil King | Aug 14th, 2006 | Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions (Nat. Biotechnol. August 2006, 24:852). |
| Jason Forse | Aug 7th, 2006 | Protein flexibility acclimatizes photosynthetic energy conversion to the ambient temperature (Nature AOP, 23 July 2006). |
| Magdalena Ivanova | Jul 31st, 2006 | Atom-by-atom analysis of global downhill protein folding (Nature 20 July 2006, 442:317). |
| Lukasz Salwinski | Jul 24th, 2006 | Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G (Science 14 July 2006, 313:187); Crystal structure of glycoprotein B from herpes simplex virus 1 (Science 14 July 2006, 313:217). |
| Heather McFarlane | Jul 3rd, 2006 | Sequencing genomes from single cells by polymerase cloning (Nat Biotechnol 2006 June, 24:680). |
| Einat Sprinzak | Jun 26th, 2006 | Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise (Nature 15 June 2006, 441:840). |
| Huiying Li | May 22nd, 2006 | Structure of the multidrug transporter EmrD from Escherichia coli (Science 5 May 2006, 312:741). |
| Marcin Apostol | May 8th, 2006 | Probing the conformation of the prion protein within a single amyloid fibril using a novel immunoconformational assay (J Biol Chem, published online ahead of print March 27, 2006, 10.1074/jbc.M601349200). |
| Markus Kaufmann | Apr 10th, 2006 | High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes (PNAS 28 March 2006, 103:4841). |
| James Stroud | Mar 27th, 2006 | A specific amyloid-beta protein asembly in the brain impairs memory.. |
| Howard Chang | Mar 20th, 2006 | Genome-wide Detection of Polymorphisms at Nucleotide Resolution with a Single DNA Microarray. |
| Howard Chang | Mar 13th, 2006 | Designed divergent evolution of enzyme function. |
| Michael Sawaya | Feb 13th, 2006 | Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus (Nature 2006 Feb 2, 439:612). |
| Arturo Medrano-Soto | Feb 6th, 2006 | Adaptive evolution of bacterial metabolic networks by horizontal gene transfer (Nature Genetics 2005 Dec, 37:1372). |
| Morgan Beeby | Jan 30th, 2006 | The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites (Cell 13 Jan 2006, 124:61). |
| Poh Teng | Jan 16th, 2006 | . |
| Lukasz Salwinski | Dec 5th, 2005 | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gamma-c receptors. |
| Einat Sprinzak | Nov 21st, 2005 | Oncogenic pathway signatures in human cancers as a guide to targeted therapies (Nature AOP, 6 Nov 2005). |
| Lukasz Goldschmidt | Oct 10th, 2005 | Crystallographic refinement by knowledge-based exploration of complex energy landscapes (Structure Sept 2005, 13:1311). |
| Daniel Anderson | Aug 8th, 2005 | Barker D, Pagel M (2005) Predicting Functional Gene Links from Phylogenetic-Statistical Analyses of Whole Genomes. PLoS Comp Biol 1(1): e3. |
| James Stroud | Aug 1st, 2005 | Multiplexed detection of pathogen DNA with DNA-based fluorescence nanobarcodes (Nat. Biotechnol. Jul 2005, 23:885). |
| Howard Chang | Jul 25th, 2005 | Amyloid ion channels: A common structural link for protein-misfolding disease. Proc Natl Acad Sci U S A. 2005 Jul 14. |
| Huiying Li | Jun 6th, 2005 | Systematic interpretation of genetic interactions using protein networks (Nature Biotech. May 2005, 23:561). |
| Morgan Beeby | May 16th, 2005 | Computational thermostabilization of an enzyme. (Science 6 May 2005, 308:857). |
| Rebecca Nelson | Apr 4th, 2005 | Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex (Science 18 March 2005, 307:1776). |
| Lukasz Salwinski | Mar 28th, 2005 | Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis. Nature. 2005 Mar 24;434(7032):505-9. . |
| Einat Sprinzak | Feb 28th, 2005 | Highly conserved non-coding sequences are associated with vertebrate development. Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, Vavouri T, Smith SF, North P, Callaway H, Kelly K, Walter K, Abnizova I, Gilks W, Edwards YJ, Cooke JE, Elgar G. PLoS Biol. 2005 Jan;3(1):e7. Epub 2004 Nov 11.. |
| Markus Kaufmann | Jan 31st, 2005 | Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils (Science 14 Jan 2005, 307:262). |
| James Stroud | Dec 20th, 2004 | Mitochondrial fission proteins regulate programmed cell death in yeast (Genes Dev. 15 Nov 2004, 18:2785). |
| Howard Chang | Dec 13th, 2004 | Human prion protein with valine 129 prevents expression of variant CJD phenotype. Science, 2004, 306:1793-1796. Wadsworth JD, Asante EA, Desbruslais M, Linehan JM, Joiner S, Gowland I, Welch J, Stone L, Lloyd SE, Hill AF, Brandner S, Collinge J.. |
| Stuart Sievers | Nov 29th, 2004 | Conservation of Orientation and Sequence in Protein Domain-Domain Interactions. Stephen J. Littler and Simon J. Hubbard Journal of Molecular Biology doi:10.1016/j.jmb.2004.11.011 . |
| Yingssu Tsai | Nov 22nd, 2004 | Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks Singleton et al. Nature vol 432, 187-193. |
| Michael Sawaya | Nov 15th, 2004 | Origin of icosahedral symmetry in viruses (PNAS 2 Nov 2004, 101:15556). |
| Richard Llewellyn | Nov 8th, 2004 | Macrodomain Organization of the E.coli Chromosome. Mich?le Valens, St?phanie Penaud, Mich?le Rossignol, Fran?ois Cornet, and Fr?d?ric Boccard . EMBO J. 2004 23: 4330-4341 . |
| Huiying Li | Nov 1st, 2004 | A glycine-dependent riboswitch that uses cooperative binding to control gene expression (Science 8 Oct 2004, 306:275). |
| Morgan Beeby | Oct 25th, 2004 | The site specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination (Nature Biotechnol. Oct 2004, 22(10):1297).. |
| Christopher Miller | Sep 27th, 2004 | Genomic analysis of regulatory network dynamics reveals large topological changes. (Nature 16 Sept 2004, 431:308). |
| Rebecca Nelson | Aug 23rd, 2004 | Genetic analysis of genome-wide variation in human gene expression (Nature 12 Aug 2004, 430:743). |
| Marcin Apostol | Jul 12th, 2004 | Computational design of a biologically active enzyme (Science 25 June 2004, 304:1967). |
| Markus Kaufmann | Jun 28th, 2004 | Walburger A, Koul A, Ferrari G, Nguyen L, Prescianotto-Baschong C, Huygen K, Klebl B, Thompson C, Bacher G, Pieters J. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4. Epub 2004 May 20.. |
| Magdalena Ivanova | May 17th, 2004 | Integrating high-throughput and computational data elucidates bacterial networks. (Nature 6 May 2004, 429:92). |
| Michael Sawaya | May 10th, 2004 | Detecting selection using a single genome sequence of M. tuberculosis and P. falciparum. Plotkin JB, Dushoff J, Fraser HB. Nature. 2004 Apr 29;428(6986):942-5. . |
| Morgan Beeby | Apr 5th, 2004 | Structure-based assembly of protein complexes in yeast (Science 26 Mar 2004, 303:2026). |
| Rebecca Nelson | Mar 22nd, 2004 | Community structure and metabolism through reconstruction of microbial genomes from the environment (Nature 4 Mar 2004, 428:37). |
| Huiying Li | Feb 2nd, 2004 | Functional genomic hypothesis generation and experimentation by a robot
scientist (Nature 15 Jan 2004, 427:247). |
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| Magdalena Ivanova | Nov 10th, 2003 | RNA molecules stimulate prion protein conversion (Nature 16 Oct 2003, 425:717). |
| Marcin Apostol | Oct 20th, 2003 | Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules (Science 10 Oct 2003, 302:249). |
| Richard Llewellyn | Sep 29th, 2003 | Evolutionary conservation of motif constituents in the yeast protein interaction network (Nat. Genet. 14 Sept 2003, Online publication). |
| Rebecca Nelson | Sep 15th, 2003 | Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR (Science 5 Sept 2003, 301:1383). |
| Christopher Miller | Aug 11th, 2003 | . |
| Lukasz Salwinski | Jul 21st, 2003 | Systematic discovery of analogous enzymes in thiamin biosynthesis. Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B, Bork P. Nat Biotechnol. 2003 Jul;21(7):790-5. . |
| Huiying Li | Jul 7th, 2003 | Watching a protein as it functions with 150-ps time-resolved x-ray crystallography (Science 20 Jun 2003, 300:1944). |
| Morgan Beeby | Jun 30th, 2003 | CtBN/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission (EMBO J, 16 Jun 2003, 22:3122). |
| Debnath Pal | May 26th, 2003 | Protein-protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces (PNAS 13 May 2003, 100:5772). |
| Rebecca Nelson | May 12th, 2003 | The genome sequence of Bacillus Anthracis Ames and comparison to closely related bacteria (Nature 1 May 2003, 423:81). |
| Markus Kaufmann | May 5th, 2003 | DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis (Cell 18 Apr 2003, 113:183). |
| Lukasz Salwinski | Mar 3rd, 2003 | The study of macromolecular complexes by quantitative proteomics (Nat. Genet. March 2003, 33:349). |
| Huiying Li | Jan 13th, 2003 | Directed evolution of substrate-optimized GroEL/S chaperonins (Cell Dec. 2002, 111:1027) . |
| Rebecca Nelson | Jan 6th, 2003 | The Mouse Genome (Nature 5 Dec 2002). |
| Debnath Pal | Nov 11th, 2002 | Sequence and Structural Differences between Enzyme and Nonenzyme Homologs. Todd A, Orengo C, Thornton J. Structure (Camb) 2002 Oct;10(10):1435 . |
| Morgan Beeby | Sep 30th, 2002 | Hierarchical Organization of Modularity in Metabolic Networks. |
| Magdalena Ivanova | Aug 26th, 2002 | Transmission of prions. C. Weissmann et. al. Proc. Natl. Acad. Sci. USA, 10.1073/pnas.172403799. |
| Lukasz Salwinski | Aug 19th, 2002 | Functional profiling of the Saccharomyces cerevisiae genome. Nature 418:387-391. Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast. Science 297:395-400.. |
| Huiying Li | Jun 10th, 2002 | 1. Crystal structure and mechanism of a calcium-gated potassium channel (Nature 2002, 417:515), 2. The open pore conformation of potassium channels (Nature 2002, 417:523) . |
| Rebecca Nelson | May 20th, 2002 | The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism (Science 2002, 296:1091). |
| Morgan Beeby | Mar 4th, 2002 | The genome sequence of Schizosaccharomyces pombe (Nature 2002, 415:871). |
| Magdalena Ivanova | Feb 11th, 2002 | Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators (Nature 31 Jan 2002, 415:549). |
| Magdalena Ivanova | Feb 4th, 2002 | Protein topology and stability define the space of allowed sequences (PNAS 2002 Early edition: 10.1073/pnas.032405199). |
| Huiying Li | Sep 24th, 2001 | Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding casette (ABC) transporters (Science 2001, 293:1793). |
| Rebecca Nelson | Sep 10th, 2001 | A relationship between gene expression and protein interactions on the proteome scale: analysis of the bacteriophage T7 and the yeast Saccharomyces cerevisiae (Nucleic Acids Research 2001, 29:3513). |
| Rebecca Nelson | Apr 2nd, 2001 | Cyclophilin A regulates HIV-1 infectivity, as demonstrated
by gene targeting in human T cells . |
