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Im interested in using computational biology to tackle interesting questions
in biology, coupled with experimental validation and design. My long-term plans
include interests in three general areas:
LOGIC ANALYSIS A primary area of interest is the origins of complex traits, phenotypes, and disease states dictated by
combinations of events. While individual mutations or proteins account for many of the phenotypes observed within or between populations, it is increasingly clear that
combinations of loci act in concert to define diseases and complex traits. I am developing methods that can identify these events/loci from analysis of genomic data.
 COMPARATIVE METHODS
Using comparative computational methods, including Rosetta Stone, Phylogenetic Profiles,
Gene Neighbor and Gene Cluster, to discover novel cellular interactions
and networks. We are using Escherichia coli as a model organism to validate our predictions.
BIOLOGICAL NETWORKS
Im interested in using genomic context (gene fusion, operon structure, ternary phylogenetic data) to elucidate the directional and conditional relationships of
cellular networks.
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